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SY SY - Synaptic Systems SY SY - Synaptic Systems

Synaptotagmin 1
cytoplasmic tail - 105 008

Ca2+-sensor on synaptic vesicles, triggers neurotransmitter release

Recombinant rabbit purified IgG
415.00 USD
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Cat. No. 105 008 50 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 100 up to 1 : 1000 gallery  
Clone Rb41.1
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 80 to 421 from rat Synaptotagmin1 (UniProt Id: P21707)
Epitop Epitop: AA 150 to 240 from rat Synaptotagmin1 (UniProt Id: P21707)
Reactivity Reacts with: rat (P21707), mouse (P46096), human (P21579), mammals, zebrafish.
Other species not tested yet.
Specificity Specific for mammalian synaptotagmin 1, no cross-reactivity to other synaptotagmins. (K.O. verified)
Remarks

This antibody is a chimeric antibody based on the well known monoclonal mouse antibody clone 41.1. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.
Since synaptotagmin 1 is unevenly expressed in neuronal subpopulations and may, in fact, be missing from some, it is not well suited as a general marker for synapses.

WB: Non-boiled samples are recommended for SDS-PAGE.

Datasheet 105_008.pdf


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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com