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Munc 13-1 - 126 102

Mammalian homologues of the C. elegans unc-13 gene essential for exocytosis

Polyclonal rabbit antiserum
350.00 USD
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Cat. No. 126 102 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: 1 : 500 (see remarks) gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: not tested yet
ELISA: (see remarks)
Immunogen Recombinant protein corresponding to AA 3 to 317 from rat Munc13-1 (UniProt Id: Q62768)
Reactivity Reacts with: human (Q9UPW8), rat (Q62768), mouse (Q4KUS2), zebrafish.
Other species not tested yet.
Specificity Specific for munc 13-1. (K.O. verified)
Remarks

IP: For most effective IP use the solubilization protocol described in the ELISA protocol. Consider that protein-protein interaction may be affected.

ICC: This antibody gives much better results in ICC than the monoclonal antibody.

ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 126 111 as capture antibody (protocol for sandwich-ELISA).

Datasheet 126_102.pdf


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References for Munc 13-1 - 126 102

Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: . 126 102 WB; tested species: mouse
SNARE Complex-associated Proteins in the Lateral Amygdala of Macaca mullatta Following Long-term Ethanol Drinking.
Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA
Alcoholism, clinical and experimental research (2018) : . 126 102 WB; tested species: monkey
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.
Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB, Peng HY
Cell death & disease (2018) 98: 811. 126 102 WB, IHC; KD verified; tested species: rat
Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2.
Gioia DA, Alexander N, McCool BA
Frontiers in neuroscience (2017) 11: 424. 126 102 WB; tested species: mouse
Differential Expression of Munc13-2 Produces Unique Synaptic Phenotypes in the Basolateral Amygdala of C57BL/6J and DBA/2J Mice.
Gioia DA, Alexander NJ, McCool BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3643: 10964-10977. 126 102 WB
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 126 102 WB
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.
Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB, Peng HY
Cell death & disease (2018) 98: 811. 126 102 WB, IHC; KD verified; tested species: rat
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons.
Rinetti GV, Schweizer FE
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 309: 3157-66. 126 102 IHC
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com