Synaptic Systems

Cat. No.: 417 003

Amount: 50 µg

Price: $380.00

Cat. No. 417 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) gallery IP: not tested yet ICC: 1 : 500 gallery IHC: not tested yet IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 2 to 118 from mouse METTL3 (UniProt Id: Q8C3P7)
Reactivity	Reacts with: mouse (Q8C3P7), human (Q86U44), rat (F7FFC6). Other species not tested yet.
Specificity	Specific for isoform 1 K.D. validated PubMed: 34108665
Data sheet	417_003.pdf

m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis.
Cieśla M, Ngoc PCT, Muthukumar S, Todisco G, Madej M, Fritz H, Dimitriou M, Incarnato D, Hellström-Lindberg E, Bellodi C
Molecular cell (2023) 837: 1165-1179.e11. 417 003 WB; KD verified; tested species: human

RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, et al.
Cell research (2021) : . 417 003 WB; KD verified; tested species: human

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, et al.
Molecular cell (2021) 8116: 3368-3385.e9. 417 003 WB; tested species: human

Cat. No.: 417 003

Amount: 50 µg

Price: $380.00

ICC

Background

Protocols

METTL3 antibody - 417 003 K.D.