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SY SY - Synaptic Systems SY SY - Synaptic Systems

m6A - 202 003

Antibody against N6-methyladenosine modifications of RNA and DNA

Polyclonal rabbit purified antibody
450.00 USD
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Cat. No. 202 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) suitable for Dot Blot gallery  
IP: yes (see remarks)
ICC: 1 : 200
IHC: not tested yet
IHC-P/FFPE: 1 : 100
ELISA: yes suitable for sandwich-ELISA gallery  
Immunogen N6-methyladenosine fused to BSA.
Reactivity Reacts with: human, rat, mouse, eukaryotes, prokaryotes.
Other species not tested yet.
Specificity Specific for N6-methyladenosine (m6A) with some cross-reactivity to m6Am.
Remarks

IP: Extracts from eukaryotic and prokaryotic cells. Standard protocol for the IP of nuclear extracts is provided with the product.
For the isolation of m6A modified RNA from total or mRNA preparations the protocol according to Dominissini et al. (2013) is recommended.

Datasheet 202_003.pdf


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References for m6A - 202 003

HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Immuno-Northern Blotting: Detection of Modified RNA Using Gel Separation and Antibodies to Modified Nucleosides.
Mishima E, Abe T
Methods in molecular biology (Clifton, N.J.) (2019) 1870: 179-187. 202 003 WB
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.
Zhang M, Yang S, Nelakanti R, Zhao W, Liu G, Li Z, Liu X, Wu T, Xiao A, Li H
Cell research (2020) : . 202 003 DOTBLOT
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Shen C, Sheng Y, Zhu AC, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, et al.
Cell stem cell (2020) : . 202 003 DOTBLOT; tested species: human,mouse
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
Tirumuru N, Wu L
The Journal of biological chemistry (2019) : . 202 003 WB, DOTBLOT; tested species: human
Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification.
Huang T, Guo J, Lv Y, Zheng Y, Feng T, Gao Q, Zeng W
Journal of animal science and biotechnology (2019) 10: 63. 202 003 DOTBLOT; tested species: mouse
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site.
Selberg S, Blokhina D, Aatonen M, Koivisto P, Siltanen A, Mervaala E, Kankuri E, Karelson M
Cell reports (2019) 2613: 3762-3771.e5. 202 003 DOTBLOT; tested species: human
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications.
Matsuzawa S, Wakata Y, Ebi F, Isobe M, Kurosawa N
PloS one (2019) 1410: e0223197. 202 003 DOTBLOT
Newly identified DNA methyltransferases of Ixodes ricinus ticks.
Kotsarenko K, Vechtova P, Hammerova Z, Langova N, Malinovska L, Wimmerova M, Sterba J, Grubhoffer L
Ticks and tick-borne diseases (2019) : 101348. 202 003 DOTBLOT
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells.
Yan G, Yuan Y, He M, Gong R, Lei H, Zhou H, Wang W, Du W, Ma T, Liu S, Xu Z, et al.
Molecular therapy. Nucleic acids (2019) 19: 421-436. 202 003 DOTBLOT; tested species: human,mouse
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels.
Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L
Oncotarget (2018) 93: 3752-3764. 202 003 DOTBLOT; tested species: human
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.
Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C
Scientific reports (2018) 81: 1415. 202 003 DOTBLOT
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
A potentially abundant junctional RNA motif stabilized by m6A and Mg2.
Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM
Nature communications (2018) 91: 2761. 202 003 DOTBLOT
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer.
Wang X, Li Z, Kong B, Song C, Cong J, Hou J, Wang S
Oncotarget (2017) 858: 98918-98930. 202 003 DOTBLOT
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, et al.
Cell reports (2017) 1811: 2622-2634. 202 003 DOTBLOT; tested species: human
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
Mouse Maternal High-Fat Intake Dynamically Programmed mRNA m⁶A Modifications in Adipose and Skeletal Muscle Tissues in Offspring.
Li X, Yang J, Zhu Y, Liu Y, Shi X, Yang G
International journal of molecular sciences (2016) 178: . 202 003 DOTBLOT
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs.
Zhou C, Liu Y, Li X, Zou J, Zou S
Bone research (2016) 4: 16033. 202 003 DOTBLOT
Genome-wide detection of high abundance N6-methyladenosine sites by microarray.
Li Y, Wang Y, Zhang Z, Zamudio AV, Zhao JC
RNA (New York, N.Y.) (2015) 218: 1511-8. 202 003 DOTBLOT
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.
Zhang M, Zhang Y, Ma J, Guo F, Cao Q, Zhang Y, Zhou B, Chai J, Zhao W, Zhao R
PloS one (2015) 107: e0133788. 202 003 DOTBLOT; tested species: mouse
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.
Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, et al.
PloS one (2015) 1011: e0143756. 202 003 WB, DOTBLOT
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
Methylation by NSun2 represses the levels and function of microRNA 125b.
Yuan S, Tang H, Xing J, Fan X, Cai X, Li Q, Han P, Luo Y, Zhang Z, Jiang B, Dou Y, et al.
Molecular and cellular biology (2014) 3419: 3630-41. 202 003 DOTBLOT
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C, et al.
Nature chemical biology (2011) 712: 885-7. 202 003 DOTBLOT
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Dynamic landscape and evolution of m6A methylation in human.
Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R
Nucleic acids research (2020) : . 202 003 IP; tested species: human
METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.
Yang DD, Chen ZH, Yu K, Lu JH, Wu QN, Wang Y, Ju HQ, Xu RH, Liu ZX, Zeng ZL
Frontiers in oncology (2020) 10: 115. 202 003 IP; tested species: human
Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury.
Zhao TX, Wang JK, Shen LJ, Long CL, Liu B, Wei Y, Han LD, Wei YX, Wu SD, Wei GH
Environmental pollution (Barking, Essex : 1987) (2020) 259: 113911. 202 003 IP; tested species: rat
Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension.
Su H, Wang G, Wu L, Ma X, Ying K, Zhang R
BMC genomics (2020) 211: 39. 202 003 IP; tested species: rat
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification.
Parker MT, Knop K, Sherwood AV, Schurch NJ, Mackinnon K, Gould PD, Hall AJ, Barton GJ, Simpson GG
eLife (2020) 9: . 202 003 IP
SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference.
Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen PR
Cell chemical biology (2020) : . 202 003 IP; tested species: human
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway.
Huang T, Liu Z, Zheng Y, Feng T, Gao Q, Zeng W
Cell death & disease (2020) 111: 37. 202 003 DOTBLOT, IP; tested species: mouse
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry (2020) : . 202 003 IP; tested species: human
Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver.
Jabs S, Biton A, Bécavin C, Nahori MA, Ghozlane A, Pagliuso A, Spanò G, Guérineau V, Touboul D, Giai Gianetto Q, Chaze T, et al.
Nature communications (2020) 111: 1344. 202 003 IP; tested species: mouse
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.
Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K, et al.
Cell reports (2020) 311: 107464. 202 003 DOTBLOT, IP; tested species: mouse
TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2.
Cen S, Li J, Cai Z, Pan Y, Sun Z, Li Z, Ye G, Zheng G, Li M, Liu W, Yu W, et al.
EBioMedicine (2020) 54: 102722. 202 003 IP; tested species: human
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine.
Wang Y, Xiao Y, Dong S, Yu Q, Jia G
Nature chemical biology (2020) : . 202 003 IP; tested species: human,mouse
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY, et al.
Nature communications (2019) 101: 2782. 202 003 DOTBLOT, IP; tested species: human
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature communications (2019) 101: 1898. 202 003 DOTBLOT, IP; tested species: mouse
METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.
Li T, Hu PS, Zuo Z, Lin JF, Li X, Wu QN, Chen ZH, Zeng ZL, Wang F, Zheng J, Chen D, et al.
Molecular cancer (2019) 181: 112. 202 003 IP; tested species: human
Profiling of RNA N6-methyladenosine methylation during follicle selection in chicken ovary.
Fan Y, Zhang C, Zhu G
Poultry science (2019) : . 202 003 IP; tested species: chicken
The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants.
Pontier D, Picart C, El Baidouri M, Roudier F, Xu T, Lahmy S, Llauro C, Azevedo J, Laudié M, Attina A, Hirtz C, et al.
Life science alliance (2019) 23: . 202 003 IP
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice.
Zhang F, Zhang YC, Liao JY, Yu Y, Zhou YF, Feng YZ, Yang YW, Lei MQ, Bai M, Wu H, Chen YQ, et al.
PLoS genetics (2019) 155: e1008120. 202 003 IP
Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.
Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF
Cell (2019) : . 202 003 DOTBLOT, IP
Genome-wide identification of mRNA 5-methylcytosine in mammals.
Huang T, Chen W, Liu J, Gu N, Zhang R
Nature structural & molecular biology (2019) 265: 380-388. 202 003 IP; tested species: human
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials.
McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY, Mason CE
Nature communications (2019) 101: 579. 202 003 IP; tested species: e. coli
Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.
Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, et al.
Nature communications (2019) 101: 1858. 202 003 IP; tested species: human,mouse
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, et al.
Cancer cell (2019) 354: 677-691.e10. 202 003 DOTBLOT, IP; tested species: human
Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice.
Wang Y, Mao J, Wang X, Lin Y, Hou G, Zhu J, Xie B
Epigenomics (2019) : . 202 003 IP; tested species: mouse
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, et al.
Autophagy (2019) : 1-19. 202 003 DOTBLOT, IP; tested species: human,rat
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.
Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ
Nucleic acids research (2019) : . 202 003 IP; tested species: mouse
FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur JJ, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, et al.
Nature chemical biology (2019) : . 202 003 IP; tested species: mouse
RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening.
Zhou L, Tian S, Qin G
Genome biology (2019) 201: 156. 202 003 IP
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network.
Cheng M, Sheng L, Gao Q, Xiong Q, Zhang H, Wu M, Liang Y, Zhu F, Zhang Y, Zhang X, Yuan Q, et al.
Oncogene (2019) : . 202 003 IP; tested species: human,mouse
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Garcia-Campos MA, Edelheit S, Toth U, Safra M, Shachar R, Viukov S, Winkler R, Nir R, Lasman L, Brandis A, Hanna JH, et al.
Cell (2019) : . 202 003 IP; tested species: human,mouse
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.
Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R
Stroke (2019) : STROKEAHA119026433. 202 003 DOTBLOT, IP; tested species: mouse
m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
Bushkin GG, Pincus D, Morgan JT, Richardson K, Lewis C, Chan SH, Bartel DP, Fink GR
Nature communications (2019) 101: 3414. 202 003 IP; tested species: fission yeast
The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
Hsu PJ, Shi H, Zhu AC, Lu Z, Miller N, Edens BM, Ma YC, He C
The Journal of biological chemistry (2019) : . 202 003 IP; tested species: mouse
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats.
Wang Y, Zheng Y, Guo D, Zhang X, Guo S, Hui T, Yue C, Sun J, Guo S, Bai Z, Cai W, et al.
Frontiers in genetics (2019) 10: 1318. 202 003 IP
Distinct m6A methylome profiles in poly(A) RNA from Xenopus laevis testis and that treated with atrazine.
Sai L, Li Y, Zhang Y, Zhang J, Qu B, Guo Q, Han M, Jia Q, Yu G, Li K, Bo C, et al.
Chemosphere (2019) 245: 125631. 202 003 IP; tested species: frog
m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma.
Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, Yin M, et al.
Molecular cancer (2019) 181: 188. 202 003 IP; tested species: human
m6A RNA modification modulates gene expression and cancer-related pathways in clear cell renal cell carcinoma.
Chen Y, Zhou C, Sun Y, He X, Xue D
Epigenomics (2019) : . 202 003 IP; tested species: human
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, et al.
European journal of heart failure (2019) : . 202 003 IP; tested species: human
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes.
Koh CWQ, Goh YT, Goh WSS
Nature communications (2019) 101: 5636. 202 003 IP; tested species: human
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer.
Jin H, Ying X, Que B, Wang X, Chao Y, Zhang H, Yuan Z, Qi D, Lin S, Min W, Yang M, et al.
EBioMedicine (2019) : . 202 003 IP; tested species: mouse
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Zou D, Dong L, Li C, Yin Z, Rao S, Zhou Q
Cancer cell international (2019) 19: 321. 202 003 DOTBLOT, IP; tested species: human
m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation.
Jia R, Chai P, Wang S, Sun B, Xu Y, Yang Y, Ge S, Jia R, Yang YG, Fan X
Molecular cancer (2019) 181: 161. 202 003 IP; tested species: human
TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m6A-demethylation of Nanog mRNA.
Wang Y, Wang R, Yao B, Hu T, Li Z, Liu Y, Cui X, Cheng L, Song W, Huang S, Fu X, et al.
Science China. Life sciences (2019) : . 202 003 IP; tested species: mouse
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry (2019) : . 202 003 IP; tested species: human
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, et al.
Nature communications (2019) 101: 4892. 202 003 IP; tested species: mouse
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, et al.
Nature communications (2019) 101: 4695. 202 003 IP; tested species: human
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, et al.
Molecular cell (2019) : . 202 003 IP; tested species: mouse
Distinct methylation levels of mature microRNAs in gastrointestinal cancers.
Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D, Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, et al.
Nature communications (2019) 101: 3888. 202 003 IP; tested species: mouse
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication.
Miao Z, Zhang T, Qi Y, Song J, Han Z, Ma C
Plant physiology (2019) : . 202 003 DOTBLOT, IP
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Tsai K, Courtney DG, Cullen BR
PLoS pathogens (2018) 142: e1006919. 202 003 IP
N6-Methyladenine DNA Modification in the Human Genome.
Xiao CL, Zhu S, He M, Chen , Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, et al.
Molecular cell (2018) 712: 306-318.e7. 202 003 IP; tested species: human
DNA N6-Adenine Methylation in Arabidopsis thaliana.
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H, et al.
Developmental cell (2018) 453: 406-416.e3. 202 003 DOTBLOT, IP
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.
Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, He Q, et al.
Cell death & disease (2018) 912: 1169. 202 003 DOTBLOT, IP; tested species: human
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell (2018) 694: 636-647.e7. 202 003 DOTBLOT, IP; tested species: mouse
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, et al.
Neuron (2018) 992: 389-403.e9. 202 003 IP; tested species: mouse
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, et al.
Cell (2018) 1721-2: 90-105.e23. 202 003 DOTBLOT, IP; tested species: human
RNA Modification Level Estimation with pulseR.
Boileau E, Dieterich C
Genes (2018) 912: . 202 003 IP; tested species: human
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons.
Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, et al.
Molecular cell (2018) : . 202 003 DOTBLOT, IP; tested species: drosophila
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, et al.
Cell stem cell (2018) 222: 191-205.e9. 202 003 IP
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) (2018) : . 202 003 IP; tested species: pig
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, et al.
Molecular cell (2018) 696: 1028-1038.e6. 202 003 IP; tested species: mouse
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, et al.
Neuron (2018) 972: 313-325.e6. 202 003 IP; tested species: mouse
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, et al.
Nature cell biology (2018) 203: 285-295. 202 003 DOTBLOT, IP
Viral and cellular N6-methyladenosine and N6,2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.
Tan B, Liu H, Zhang S, da Silva SR, Zhang L, Meng J, Cui X, Yuan H, Sorel O, Zhang SW, Huang Y, et al.
Nature microbiology (2018) 31: 108-120. 202 003 IP
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC, et al.
Nature neuroscience (2018) 212: 195-206. 202 003 DOTBLOT, IP
N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential.
Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: mouse
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, et al.
Nucleic acids research (2018) : . 202 003 IP; tested species: human
METTL3-mediated m6A modification is required for cerebellar development.
Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, et al.
PLoS biology (2018) 166: e2004880. 202 003 IP; tested species: mouse
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, et al.
Nature neuroscience (2018) : . 202 003 DOTBLOT, IP; tested species: mouse
Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, et al.
Neuron (2018) 992: 283-292.e5. 202 003 IP; tested species: mouse
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, et al.
Cell research (2018) : . 202 003 IP; tested species: mouse
Identification and analysis of adenine N6-methylation sites in the rice genome.
Zhou C, Wang C, Liu H, Zhou Q, Liu Q, Guo Y, Peng T, Song J, Zhang J, Chen L, Zhao Y, et al.
Nature plants (2018) 48: 554-563. 202 003 IP
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, et al.
Genes & development (2018) 325-6: 415-429. 202 003 IP; tested species: mouse
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development.
Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA, Pillai RS
Molecular cell (2018) : . 202 003 IP; tested species: mouse
FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.
Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL
Journal of lipid research (2018) 598: 1446-1460. 202 003 IP; tested species: mouse
N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA.
Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, et al.
Genome biology (2018) 191: 200. 202 003 IP
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, et al.
Cell reports (2018) 257: 1816-1828.e4. 202 003 IP; tested species: mouse
Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS
Nucleic acids research (2018) : . 202 003 IP; tested species: human
N6-Methyladenosine Inhibits Local Ribonucleolytic Cleavage to Stabilize mRNAs in Arabidopsis.
Anderson SJ, Kramer MC, Gosai SJ, Yu X, Vandivier LE, Nelson ADL, Anderson ZD, Beilstein MA, Fray RG, Lyons E, Gregory BD, et al.
Cell reports (2018) 255: 1146-1157.e3. 202 003 IP
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism.
Jiang Q, Sun B, Liu Q, Cai M, Wu R, Wang F, Yao Y, Wang Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018) : fj201801393RRR. 202 003 IP; tested species: pig
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, et al.
Nature communications (2018) 91: 4772. 202 003 IP; tested species: mouse
Refined RIP-seq protocol for epitranscriptome analysis with low input materials.
Zeng Y, Wang S, Gao S, Soares F, Ahmed M, Guo H, Wang M, Hua JT, Guan J, Moran MF, Tsao MS, et al.
PLoS biology (2018) 169: e2006092. 202 003 IP; tested species: human
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S
Cell research (2018) : . 202 003 DOTBLOT, IP; tested species: human
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, et al.
Molecular cell (2017) 661: 22-37.e9. 202 003 IP; tested species: mouse
Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs.
Martínez-Pérez M, Aparicio F, López-Gresa MP, Bellés JM, Sánchez-Navarro JA, Pallás V
Proceedings of the National Academy of Sciences of the United States of America (2017) 11440: 10755-10760. 202 003 DOTBLOT, IP
Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern.
Tao X, Chen J, Jiang Y, Wei Y, Chen Y, Xu H, Zhu L, Tang G, Li M, Jiang A, Shuai S, et al.
BMC genomics (2017) 181: 336. 202 003 DOTBLOT, IP
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.
Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC, Mullen AC
Cell reports (2017) 209: 2262-2276. 202 003 IP
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK
Cell (2017) 1695: 824-835.e14. 202 003 IP; tested species: human
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y
Open biology (2017) 79: . 202 003 IP
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, et al.
Cell (2017) 1714: 877-889.e17. 202 003 IP; tested species: human
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, et al.
Cancer cell (2017) 314: 591-606.e6. 202 003 IP; tested species: human
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell (2016) 623: 335-345. 202 003 IP; tested species: human
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation.
Koziol MJ, Bradshaw CR, Allen GE, Costa AS, Frezza C
Bio-protocol (2016) 621: . 202 003 IP
m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome.
Molinie B, Wang J, Lim KS, Hillebrand R, Lu ZX, Van Wittenberghe N, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y, et al.
Nature methods (2016) 138: 692-8. 202 003 IP
Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications.
Koziol MJ, Bradshaw CR, Allen GE, Costa ASH, Frezza C, Gurdon JB
Nature structural & molecular biology (2016) 231: 24-30. 202 003 IP
Decomposition of RNA methylome reveals co-methylation patterns induced by latent enzymatic regulators of the epitranscriptome.
Liu L, Zhang SW, Zhang YC, Liu H, Zhang L, Chen R, Huang Y, Meng J
Molecular bioSystems (2015) 111: 262-74. 202 003 IP
Widespread occurrence of N6-methyladenosine in bacterial mRNA.
Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C
Nucleic acids research (2015) 4313: 6557-67. 202 003 IP; tested species: e. coli
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, et al.
Cell stem cell (2015) 163: 289-301. 202 003 DOTBLOT, IP
N6-methyladenosine marks primary microRNAs for processing.
Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF
Nature (2015) 5197544: 482-5. 202 003 IP
DNA Methylation on N6-Adenine in C. elegans.
Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y
Cell (2015) 1614: 868-78. 202 003 DOTBLOT, IP
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification.
Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET
Journal of the American Chemical Society (2015) 1375: 2107-15. 202 003 IP
N6-adenosine methylation in MiRNAs.
Berulava T, Rahmann S, Rademacher K, Klein-Hitpass L, Horsthemke B
PloS one (2015) 102: e0118438. 202 003 IP
N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Dore LC, Weng X, et al.
Cell (2015) 1614: 879-892. 202 003 IP
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, et al.
Science (New York, N.Y.) (2015) 3476225: 1002-6. 202 003 IP
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR
Nature methods (2015) 128: 767-72. 202 003 DOTBLOT, IP; tested species: human,mouse
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T
Nature (2015) 5187540: 560-4. 202 003 IP
Transcriptome-wide N⁶-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification.
Li Y, Wang X, Li C, Hu S, Yu J, Song S
RNA biology (2014) 119: 1180-8. 202 003 IP
Unique features of the m6A methylome in Arabidopsis thaliana.
Luo GZ, MacQueen A, Zheng G, Duan H, Dore LC, Lu Z, Liu J, Chen K, Jia G, Bergelson J, He C, et al.
Nature communications (2014) 5: 5630. 202 003 IP
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Zhao X, Yang Y, Sun BF, Shi Y, Yang X, Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, Jin KX, et al.
Cell research (2014) 2412: 1403-19. 202 003 DOTBLOT, IP
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H, et al.
Cell (2013) 1554: 793-806. 202 003 IP
DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria.
Fioravanti A, Fumeaux C, Mohapatra SS, Bompard C, Brilli M, Frandi A, Castric V, Villeret V, Viollier PH, Biondi EG
PLoS genetics (2013) 95: e1003541. 202 003 IP
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.
Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, Amariglio N, Rechavi G
Nature protocols (2013) 81: 176-89. 202 003 IP
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, et al.
Nature neuroscience (2013) 168: 1042-8. 202 003 IP
A link between FTO, ghrelin, and impaired brain food-cue responsivity.
Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, et al.
The Journal of clinical investigation (2013) 1238: 3539-51. 202 003 IP
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, et al.
Nature (2012) 4857397: 201-6. 202 003 IP
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR
Cell (2012) 1497: 1635-46. 202 003 DOTBLOT, IP
DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo.
Xiao R, Moore DD
Current protocols in molecular biology (2011) Chapter 21: Unit21.21. 202 003 IP
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, et al.
Molecular cell (2020) : . 202 003 DOTBLOT, IP, ICC; tested species: human
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation.
Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R
PloS one (2020) 155: e0231894. 202 003 ICC; tested species: human
Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development.
Kwon J, Jo YJ, Namgoong S, Kim NH
Scientific reports (2019) 91: 8640. 202 003 ICC; tested species: mouse
A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription.
Wang Y, Sheng Y, Liu Y, Zhang W, Cheng T, Duan L, Pan B, Qiao Y, Liu Y, Gao S
Nucleic acids research (2019) : . 202 003 ICC
MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells.
Sobecki M, Souaid C, Boulay J, Guerineau V, Noordermeer D, Crabbe L
Cell reports (2018) 2510: 2891-2903.e5. 202 003 DOTBLOT, IP, ICC; tested species: human
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, et al.
Nature (2017) 5437646: 573-576. 202 003 DOTBLOT, ICC
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena.
Wang Y, Chen X, Sheng Y, Liu Y, Gao S
Nucleic acids research (2017) 4520: 11594-11606. 202 003 DOTBLOT, ICC
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, et al.
Nature communications (2016) 7: 13052. 202 003 IP, ICC; tested species: zebrafish,pig
Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.
de Wit E, Greil F, van Steensel B
Genome research (2005) 159: 1265-73. 202 003 ICC; tested species: drosophila
N6-methyladenine DNA Modification in Glioblastoma.
Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, et al.
Cell (2018) : . 202 003 DOTBLOT, IP, ICC, IHC-P; tested species: human
Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6.
Bringmann P, Lührmann R
FEBS letters (1987) 2132: 309-15. 202 003
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