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SY SY - Synaptic Systems SY SY - Synaptic Systems

GFAP - 173 004

A glial-specific type-III intermediate filament protein

Polyclonal Guinea pig antiserum
350.00 USD
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Cat. No. 173 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 432 from human GFAP (UniProt Id: P14136)
Reactivity Reacts with: human (P14136), rat (P47819), mouse (P03995), chicken, sheep.
Other species not tested yet.
Specificity Specific for GFAP, detects all isoforms.
matching control protein/peptide 173-0P
Datasheet 173_004.pdf


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References for GFAP - 173 004

SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 173 004 WB; tested species: mouse
Tanycytes and a differential fatty acid metabolism in the hypothalamus.
Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, Al-Amoudi A, Kuerschner L
Glia (2017) 652: 231-249. 173 004 WB, IHC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 173 004 WB; tested species: mouse
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, et al.
Cell reports (2019) 277: 2212-2228.e7. 173 004 ICC; tested species: mouse
Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.
Shah BS, Shimell JJ, Bamji SX
Journal of cell science (2019) 13213: . 173 004 ICC; tested species: rat
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 173 004 ICC, FACS; tested species: rat
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW
Nature protocols (2016) 1110: 1877-88. 173 004 ICC
Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway.
Pignataro L, Varodayan FP, Tannenholz LE, Protiva P, Harrison NL
Brain and behavior (2013) 32: 114-33. 173 004 ICC
Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells.
Mansel C, Fross S, Rose J, Dema E, Mann A, Hart H, Klawinski P, Vohra BPS
Neurotoxicology and teratology () 72: 58-70. 173 004 ICC; tested species: mouse
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism.
Gong J, Szegő ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 173 004 IHC; tested species: mouse
Neuropathological findings suggestive for a stroke in an alpaca (Vicugna pacos).
Schöniger S, Schütze E, Michalski D, Puchta J, Kaiser M, Härtig W
Acta veterinaria Scandinavica (2019) 611: 1. 173 004 IHC
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, et al.
Cell metabolism (2018) : . 173 004 IHC; tested species: mouse
Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.
Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wiltfang J, Wirths O
Acta neuropathologica communications (2018) 61: 108. 173 004 IHC; tested species: mouse
Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.
Ruyle BC, Klutho PJ, Baines CP, Heesch CM, Hasser EM
American journal of physiology. Regulatory, integrative and comparative physiology (2018) : . 173 004 IHC; tested species: rat
Radial glial elements in the cerebral cortex of the lesser hedgehog tenrec.
Mack AF, Künzle H, Lange M, Mages B, Reichenbach A, Härtig W
Brain structure & function (2018) : . 173 004 IHC
Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease.
Ma W, Wu M, Zhou S, Tao Y, Xie Z, Zhong Y
Journal of genetics and genomics = Yi chuan xue bao (2018) : . 173 004 IHC; tested species: mouse
Delayed histochemical alterations within the neurovascular unit due to transient focal cerebral ischemia and experimental treatment with neurotrophic factors.
Michalski D, Pitsch R, Pillai DR, Mages B, Aleithe S, Grosche J, Martens H, Schlachetzki F, Härtig W
PloS one (2017) 124: e0174996. 173 004 IHC
Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 173 004 IHC; tested species: mouse,rat,sheep
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Michalski D, Hofmann S, Pitsch R, Grosche J, Härtig W
Journal of Alzheimer's disease : JAD (2017) 592: 655-674. 173 004 IHC; tested species: mouse
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, et al.
Neuron (2017) 935: 1066-1081.e8. 173 004 IHC; tested species: human,mouse
Tanycytes and a differential fatty acid metabolism in the hypothalamus.
Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, Al-Amoudi A, Kuerschner L
Glia (2017) 652: 231-249. 173 004 WB, IHC; tested species: mouse
Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation.
Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, Wedekind F, Bauer A, Schrader J, Hartung HP, Prozorovski T, et al.
Journal of neuroinflammation (2016) 13: 48. 173 004 IHC
Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice.
Tan SZ, Prabakaran M
Virology journal (2016) 131: 191. 173 004 IHC
Excitatory amino acid transporters tonically restrain nTS synaptic and neuronal activity to modulate cardiorespiratory function.
Matott MP, Ruyle BC, Hasser EM, Kline DD
Journal of neurophysiology (2016) 1153: 1691-702. 173 004 IHC; tested species: rat
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 173 004 IHC
Relaxin increases sympathetic nerve activity and activates spinally projecting neurons in the paraventricular nucleus of nonpregnant, but not pregnant, rats.
Coldren KM, Brown R, Hasser EM, Heesch CM
American journal of physiology. Regulatory, integrative and comparative physiology (2015) 30912: R1553-68. 173 004 IHC; tested species: rat
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, et al.
Molecular medicine (Cambridge, Mass.) (2015) : . 173 004 IHC
Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines.
Schmidt F, Boltze J, Jäger C, Hofmann S, Willems N, Seeger J, Härtig W, Stolzing A
Journal of neuropathology and experimental neurology (2015) 749: 912-23. 173 004 IHC
The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation.
Stock K, Garthe A, de Almeida Sassi F, Glass R, Wolf SA, Kettenmann H
Stem cells (Dayton, Ohio) (2014) 3212: 3183-95. 173 004 IHC
Blood-brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions.
Krueger M, Härtig W, Reichenbach A, Bechmann I, Michalski D
PloS one (2013) 82: e56419. 173 004 IHC
D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.
Ehmsen JT, Ma TM, Sason H, Rosenberg D, Ogo T, Furuya S, Snyder SH, Wolosker H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3330: 12464-9. 173 004 IHC
Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.
Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T
Neural development (2012) 7: 26. 173 004 IHC
Long-lasting neuronal loss following experimental focal cerebral ischemia is not affected by combined administration of tissue plasminogen activator and hyperbaric oxygen.
Hobohm C, Laignel F, Kacza J, Küppers-Tiedt L, Heindl M, Schneider D, Grosche J, Härtig W, Michalski D
Brain research (2011) 1417: 115-26. 173 004 IHC
Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.
Bankstahl M, Breuer H, Leiter I, Märkel M, Bascuñana P, Michalski D, Bengel FM, Löscher W, Meier M, Bankstahl JP, Härtig W, et al.
eNeuro () 53: . 173 004 IHC; tested species: rat
Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery.
Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR
eNeuro () 31: . 173 004 IHC
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.
Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ
Journal of neuroinflammation (2018) 151: 7. 173 004 ICC, FACS; tested species: rat
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com