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Gephyrin - 147 018

A protein associated with inhibitory neurotransmitter receptors

Recombinant rabbit hybridoma supernatant
415.00 USD
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Cat. No. 147 018 200 µl hybridoma supernatant, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not recommended (see remarks)
IP: not recommended (see remarks)
ICC: 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC-P/FFPE: not tested yet
Clone RbmAb7a
Subtype IgG1 (κ light chain)
Immunogen Native Protein corresponding to AA 1 to 768 from rat Gephyrin (UniProt Id: Q03555)
Epitop N-terminus of gephyrin, surrounding phospho-serines 268 and 270.
Reactivity Reacts with: human (Q9NQX3), rat (Q03555), mouse (Q8BUV3), pig, goldfish, zebrafish.
Other species not tested yet.
Specificity Specific for the brain specific 93 kDa splice variant phosphorylated at Ser-270. (K.O. verified)
Remarks

WB: Clone 3B11 (cat. no. 147 111) is highly recommended.

IP: Clone 3B11 (cat. no. 147 111) is highly recommended.

IHC: For best results use the protocol of Schneider Gasser et al., 2006.
Alternatively antigen retrieval (10 mM citrate, pH 6.0, over night at 60°C) can be applied.

Datasheet 147_018.pdf


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References for Gephyrin - 147 018

A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development.
Li J, Han W, Wu K, Li YD, Liu Q, Lu W
Frontiers in molecular neuroscience (2019) 12: 213. 147 018 ICC; tested species: mouse
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 147 018 IHC; tested species: mouse
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com