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SY SY - Synaptic Systems SY SY - Synaptic Systems

Arc - 156 003

A cytoskeleton-associated protein involved in neuronal plasticity

Polyclonal rabbit purified antibody
450.00 USD
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Cat. No. 156 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 500 up to 1 : 2000 (AP staining) blot  
IP: yes
ICC: 1 : 1000
IHC: 1 : 1000 image  
IHC-P/FFPE: 1 : 1000 image  
ELISA: yes (see remarks)
Immunogen Recombinant protein corresponding to AA 1 to 396 from mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: rat (Q63053), mouse (Q9WV31).
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for arc. (K.O. verified)
matching control protein/peptide 156-0P
Remarks

ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 156 011 as capture antibody (protocol for sandwich-ELISA).

Datasheet 156_003.pdf


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References for Arc - 156 003

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.
Carmichael RE, Wilkinson KA, Craig TJ, Ashby MC, Henley JM
Scientific reports (2018) 81: 5263. 156 003 WB; tested species: rat
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, et al.
Neuron (2018) : . 156 003 WB, ICC; tested species: mouse
StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Jacobs CL, Badiee RK, Lin MZ
Nature methods (2018) 157: 523-526. 156 003 WB; tested species: human
Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex.
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2018) 2510: 533-543. 156 003 WB; tested species: rat
Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Frank RAW, Zhu F, Komiyama NH, Grant SGN
Journal of neurochemistry (2017) 1424: 504-511. 156 003 WB; tested species: mouse
BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.
Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, et al.
Molecular neurobiology (2016) 538: 5607-27. 156 003 WB, IHC
Intracellular mGluR5 plays a critical role in neuropathic pain.
Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ, et al.
Nature communications (2016) 7: 10604. 156 003 WB
Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.
Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H
Journal of neuroscience research (2016) 945: 401-8. 156 003 WB
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
Niere F, Wilkerson JR, Huber KM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3217: 5924-36. 156 003 WB, ICC; KO verified; tested species: mouse
MSK1 regulates homeostatic and experience-dependent synaptic plasticity.
Corrêa SA, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C, McKelvey K, Morris RG, Pankratov Y, Arthur JS, Frenguelli BG, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3238: 13039-51. 156 003 WB; tested species: mouse
Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training.
Holloway CM, McIntyre CK
Neurobiology of learning and memory (2011) 954: 425-32. 156 003 WB, IHC; tested species: rat
Astrocyte-neuron lactate transport is required for long-term memory formation.
Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM
Cell (2011) 1445: 810-23. 156 003 WB; tested species: rat
Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.
McReynolds JR, Donowho K, Abdi A, McGaugh JL, Roozendaal B, McIntyre CK
Neurobiology of learning and memory (2010) 933: 312-21. 156 003 WB, IHC; tested species: rat
The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation.
Wiig KA, Whitlock JR, Epstein MH, Carpenter RL, Bear MF
Neurobiology of learning and memory (2009) 921: 106-13. 156 003 WB; tested species: rat
Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation.
Jourdi H, Hsu YT, Zhou M, Qin Q, Bi X, Baudry M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2009) 2927: 8688-97. 156 003 WB; tested species: rat
Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2.
DaSilva LL, Wall MJ, P de Almeida L, Wauters SC, Januário YC, Müller J, Corrêa SA
eNeuro () 33: . 156 003 WB, IP
Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2.
DaSilva LL, Wall MJ, P de Almeida L, Wauters SC, Januário YC, Müller J, Corrêa SA
eNeuro () 33: . 156 003 WB, IP
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, et al.
Neuron (2018) : . 156 003 WB, ICC; tested species: mouse
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
Niere F, Wilkerson JR, Huber KM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3217: 5924-36. 156 003 WB, ICC; KO verified; tested species: mouse
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate.
Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM
Neuron (2008) 591: 84-97. 156 003 ICC, IHC; tested species: rat
Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription ofArc/Arg3.1and Other Immediate Early Genes.
Dunn CJ, Sarkar P, Bailey ER, Farris S, Zhao M, Ward JM, Dudek SM, Saha RN
eNeuro () 44: . 156 003 ICC; tested species: rat
Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β.
Brockett AT, Kane GA, Monari PK, Briones BA, Vigneron PA, Barber GA, Bermudez A, Dieffenbach U, Kloth AD, Buschman TJ, Gould E, et al.
PloS one (2018) 134: e0195726. 156 003 IHC; tested species: rat
Delayed Degradation and Impaired Dendritic Delivery of Intron-LackingEGFP-Arc/Arg3.1mRNA inEGFP-ArcTransgenic Mice.
Steward O, Matsudaira Yee K, Farris S, Pirbhoy PS, Worley P, Okamura K, Okuno H, Bito H
Frontiers in molecular neuroscience (2017) 10: 435. 156 003 IHC; tested species: mouse
c-Fos and Arc/Arg3.1 expression in auditory and visual cortices after hearing loss: Evidence of sensory crossmodal reorganization in adult rats.
Pernia M, Estevez S, Poveda C, Plaza I, Carro J, Juiz JM, Merchan MA
The Journal of comparative neurology (2017) 52512: 2677-2689. 156 003 IHC
Homeostatic Changes in GABA and Glutamate Receptors on Excitatory Cortical Neurons during Sleep Deprivation and Recovery.
Del Cid-Pellitero E, Plavski A, Mainville L, Jones BE
Frontiers in systems neuroscience (2017) 11: 17. 156 003 IHC; tested species: mouse
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells.
Lempel AA, Coll L, Schinder AF, Uchitel OD, Piriz J
Journal of neurochemistry (2017) 1402: 257-267. 156 003 IHC; tested species: mouse
BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.
Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, et al.
Molecular neurobiology (2016) 538: 5607-27. 156 003 WB, IHC
Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner.
Gröger N, Bock J, Goehler D, Blume N, Lisson N, Poeggel G, Braun K
Brain structure & function (2016) 2211: 679-85. 156 003 IHC
The supramammillary nucleus and the claustrum activate the cortex during REM sleep.
Renouard L, Billwiller F, Ogawa K, Clément O, Camargo N, Abdelkarim M, Gay N, Scoté-Blachon C, Touré R, Libourel PA, Ravassard P, et al.
Science advances (2015) 13: e1400177. 156 003 IHC
Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory.
Nakayama D, Iwata H, Teshirogi C, Ikegaya Y, Matsuki N, Nomura H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 352: 819-30. 156 003 IHC; tested species: mouse
Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation.
Hopp SC, D'Angelo HM, Royer SE, Kaercher RM, Crockett AM, Adzovic L, Wenk GL
Journal of neuroinflammation (2015) 12: 56. 156 003 IHC
The participation of cortical amygdala in innate, odour-driven behaviour.
Root CM, Denny CA, Hen R, Axel R
Nature (2014) 5157526: 269-73. 156 003 IHC; tested species: mouse
Selective localization of arc mRNA in dendrites involves activity- and translation-dependent mRNA degradation.
Farris S, Lewandowski G, Cox CD, Steward O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3413: 4481-93. 156 003 IHC; tested species: rat
The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats.
Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M, et al.
PloS one (2013) 83: e57247. 156 003 IHC; tested species: rat
Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats.
Wall VL, Fischer EK, Bland ST
Physiology & behavior (2012) 1073: 440-50. 156 003 IHC; tested species: rat
The timing for neuronal maturation in the adult hippocampus is modulated by local network activity.
Piatti VC, Davies-Sala MG, Espósito MS, Mongiat LA, Trinchero MF, Schinder AF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3121: 7715-28. 156 003 IHC; tested species: mouse
Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training.
Holloway CM, McIntyre CK
Neurobiology of learning and memory (2011) 954: 425-32. 156 003 WB, IHC; tested species: rat
Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.
McReynolds JR, Donowho K, Abdi A, McGaugh JL, Roozendaal B, McIntyre CK
Neurobiology of learning and memory (2010) 933: 312-21. 156 003 WB, IHC; tested species: rat
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate.
Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM
Neuron (2008) 591: 84-97. 156 003 ICC, IHC; tested species: rat
Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity.
Panford-Walsh R, Singer W, Rüttiger L, Hadjab S, Tan J, Geisler HS, Zimmermann U, Köpschall I, Rohbock K, Vieljans A, Oestreicher E, et al.
Molecular pharmacology (2008) 743: 595-604. 156 003 IHC; tested species: rat
Late maturation of adult-born neurons in the temporal dentate gyrus.
Snyder JS, Ferrante SC, Cameron HA
PloS one (2012) 711: e48757. 156 003 ; tested species: rat
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com