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SY SY - Synaptic Systems SY SY - Synaptic Systems

Abeta 40 - 218 203

A major component of neuritic plaques in Alzheimer's disease

Polyclonal rabbit purified antibody
450.00 USD
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Cat. No. 218 203 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 200 up to 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 100 up to 1 : 500 (see remarks) gallery  
ELISA: yes (see remarks) gallery  
Immunogen Synthetic peptide corresponding to AA 33 to 40 from human Abeta40 (UniProt Id: P05067)
Reactivity Reacts with: human (P05067), rat (P08592), mouse (P12023).
Other species not tested yet.
Specificity Specific for Abeta 40, no cross reactivity to Abeta 38 and 42.
Remarks

WB: Detects purified Abeta 40. Complex samples like brain extracts still have to be tested. Boil membrane after blotting for 3min.

IHC: Formic acid treatment required recommended protocol.

IHC-P: Formic acid treatment required.

ELISA: suitable as capture and detector antibody for sandwich-ELISA (protocol for sandwich-ELISA).

Datasheet 218_203.pdf


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References for Abeta 40 - 218 203

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.
Christensen DZ, Huettenrauch M, Mitkovski M, Pradier L, Wirths O
Frontiers in aging neuroscience (2014) 6: 139. 218 203 IHC
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com