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SY SY - Synaptic Systems SY SY - Synaptic Systems

Abeta 38/40/42/43 - 218 211

A major component of neuritic plaques in Alzheimer's disease

Monoclonal mouse purified IgG
415.00 USD
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Cat. No. 218 211 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC-P/FFPE: 1 : 1000 up to 1 : 2000 gallery  
ELISA: yes (see remarks)
Clone NT244
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067)
Epitop Epitop: AA 4 to 8 from human Abeta (UniProt Id: P05067)
Reactivity Reacts with: human (P05067), mouse (P12023).
Other species not tested yet.
Specificity Specific for Abeta 38, 40, 42, 43.

WB: Boil membrane after blotting for 3min.

IHCrecommended protocol

ELISA: Suitable as detector antibodies with 218 203, 218 403 and 218 703 as capture antibodies.

Datasheet 218_211.pdf

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References for Abeta 38/40/42/43 - 218 211

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.
Porcellotti S, Fanelli F, Fracassi A, Sepe S, Cecconi F, Bernardi C, Cimini A, Cerù MP, Moreno S
Oxidative medicine and cellular longevity (2015) 2015: 967203. 218 211 IHC
Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Reinert J, Martens H, Huettenrauch M, Kolbow T, Lannfelt L, Ingelsson M, Paetau A, Verkkoniemi-Ahola A, Bayer TA, Wirths O
Journal of Alzheimer's disease : JAD (2014) 394: 871-81. 218 211 IHC; tested species: human
Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy.
Wirths O, Hillmann A, Pradier L, Härtig W, Bayer TA
Journal of Alzheimer's disease : JAD (2013) 354: 741-9. 218 211 IHC; tested species: human
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Venkataramani V, Wirths O, Budka H, Härtig W, Kovacs GG, Bayer TA
Journal of Alzheimer's disease : JAD (2012) 292: 361-71. 218 211 IHC; tested species: human
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: | E-Mail: