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SY SY - Synaptic Systems SY SY - Synaptic Systems

Abeta 38/40/42/43 - 218 113

A major component of neuritic plaques in Alzheimer's disease

Polyclonal rabbit purified antibody
370.00 USD
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Cat. No. 218 113 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: yes
IP: not tested yet
ICC: not tested yet
IHC: 1 : 100 up to 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 1000 (see remarks) gallery  
ELISA: yes
Immunogen Synthetic peptide corresponding to AA 13 to 29 from human Abeta (UniProt Id: P05067)
Reactivity Reacts with: human (P05067), mouse (P12023), dog.
Other species not tested yet.
Specificity Recognizes Abeta 38, 40, 42, 43.
Remarks

IHC: Formic acid treatment required recommended protocol.

IHC-P: Formic acid treatment increases sensitivity and reveals more plaques.

Datasheet 218_113.pdf


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References for Abeta 38/40/42/43 - 218 113

Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Reinert J, Martens H, Huettenrauch M, Kolbow T, Lannfelt L, Ingelsson M, Paetau A, Verkkoniemi-Ahola A, Bayer TA, Wirths O
Journal of Alzheimer's disease : JAD (2014) 394: 871-81. 218 113 WB; tested species: human
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Michalski D, Hofmann S, Pitsch R, Grosche J, Härtig W
Journal of Alzheimer's disease : JAD (2017) 592: 655-674. 218 113 IHC; tested species: mouse
Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines.
Schmidt F, Boltze J, Jäger C, Hofmann S, Willems N, Seeger J, Härtig W, Stolzing A
Journal of neuropathology and experimental neurology (2015) 749: 912-23. 218 113 IHC
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com