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SY SY - Synaptic Systems SY SY - Synaptic Systems

α/β SNAP - 112 011

Peripheral membrane proteins required for membrane traffic

Monoclonal mouse purified IgG
415.00 USD
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Cat. No. 112 011 100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes (see remarks)
ICC: not recommended (denaturation of the antigen during fixation)
IHC: not tested yet
IHC-P/FFPE: not tested yet
Clone 77.1
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 295 from rat α SNAP (UniProt Id: P54921)
Reactivity Reacts with: human (P54920, P60880), rat (P54921, P60881), mouse (Q9DB05, P28663), zebrafish.
Other species not tested yet.
Specificity Specific for α- and β SNAP, does not cross-react to γ SNAP.
Remarks

IP: The antibody does not immunoprecipitate the 20 S SNARE-complex.

Datasheet 112_011.pdf


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References for alpha/beta SNAP - 112 011

CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC
The EMBO journal (2012) 314: 829-41. 112 011 WB; tested species: mouse
Sperm from hyh mice carrying a point mutation in alphaSNAP have a defect in acrosome reaction.
Bátiz LF, De Blas GA, Michaut MA, Ramírez AR, Rodríguez F, Ratto MH, Oliver C, Tomes CN, Rodríguez EM, Mayorga LS
PloS one (2009) 43: e4963. 112 011 WB; tested species: mouse
alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction.
Tomes CN, De Blas GA, Michaut MA, Farré EV, Cherhitin O, Visconti PE, Mayorga LS
Molecular human reproduction (2005) 111: 43-51. 112 011 WB; tested species: human
The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin.
Hanson PI, Otto H, Barton N, Jahn R
The Journal of biological chemistry (1995) 27028: 16955-61. 112 011 WB
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 112 011
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com