Cat. No.: 498 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 498 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to the N-terminal part of mouse NeuroD2 (UniProt Id: Q62414) |
| Reactivity |
Reacts with: mouse (Q62414), rat (Q63689). Other species not tested yet. |
| Remarks |
IHC: Antigen retrieval (10mM citrate, pH 6.0, overnight at 60°C) is recommended. |
| Data sheet | 498_003.pdf |
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NeuroD2, also referred to as Neurogenic differentiation factor 2 or NDRF, is a highly conserved member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. It is highly expressed during development, but it is also present in postmitotic neurons in adulthood, for example in the cerebellum, hippocampus, and cerebral cortex (1).
It is assumed that NeuroD2 acts as a heterodimer with other bHLH transcription factors. It can induce transcription from neuron-specific promoters containing a conserved E-box DNA sequence (1).
NeuroD2 plays a crucial role in the development of the central nervous system (2). It induces neuronal differentiation and promotes neuronal survival (1, 2). Its spectrum of effects includes involvement in the neuronal development in the cerebellum and hippocampus (2, 3), amygdala development and emotional learning (4), and contribution to the terminal neuron localization within the cortical plate (5).
Transgenic mice lacking NeuroD2 do not survive and exhibit severe neurodevelopmental defects (2).