Cat. No.: 490 011
Amount: 100 µg
Price:
$415.00
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| Cat. No. 490 011 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-158G12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse APLP2 (UniProt Id: Q06335) |
| Reactivity |
Reacts with: mouse (Q06335), rat (P15943). Other species not tested yet. |
| Specificity | K.O. validated |
| Data sheet | 490_011.pdf |
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Amyloid beta precursor like protein 1 and 2 (APLP1 and 2) and amyloid precursor protein (APP) belong to one protein family that all share considerable sequence homolgy in the amino- and carboxyl termini (1, 2). In contrast to APP, APLP1 and 2 do not contain the Abeta motif. Like APP, APLP1 and 2 are processed by alpha-, beta-, and gamma-secretase leading to a secreted ecto-domain and a membrane-anchored C-terminal fragment (3). APLPs function as synaptic adhesion molecules (SAMs) and are involved in synaptogenesis (4).
In contrast to the ubiquitously expressed APLP2, APLP1 selectively occurs in neuronal cells (4).