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Opalin antibody - 457 005

Opalin is a specific marker for myelinating oligodendrocytes
Polyclonal Guinea pig purified antibody
Cat. No.: 457 005
Amount: 50 µg
Price: $450.00
Cat. No. 457 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 up to 1 : 2000 (AP staining) gallery  
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P/FFPE: 1 : 500 up to 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 52 to 143 from mouse Opalin (UniProt Id: Q7M750)
Reactivity Reacts with: mouse (Q7M750), rat (Q56A26), human (Q96PE5).
Other species not tested yet.
Specificity Specific for Opalin
Data sheet 457_005.pdf
Cat. No.: 457 005
Quantity: 50 µg
Price: $450.00

Opalin also called Tmem10 is a transmembrane protein detected specifically in mammalian oligodendrocytes. Opalin homologs are found only in mammals and not in the genome sequences of other animal classes (1). Deficient mice are born the expected Mendelian ratio and have a normal body shape and weight. No obvious abnormalities in gross anatomy or major myelin protein components nor in the compartment of myelinated axons and oligodendrocyte maturation. Nevertheless, deficient mice display increased exploratory activity in a novel environment (2).