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Nav 1.1 - 451 003

A voltage gated sodium channel
Polyclonal rabbit purified antibody
Cat. No.: 451 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 451 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 45 from mouse Nav1.1 (UniProt Id: A2APX8)
Reactivity Reacts with: mouse (A2APX8), rat (P04774).
Other species not tested yet.
Specificity Due to high sequence homology between the N-termini of Nav1.1-Nav1.9 this antibody probably cross-reacts with other Voltage-gated sodium channel subunit alpha subtypes.
Data sheet 451_003.pdf
Cat. No.: 451 003
Quantity: 50 µg
Price: 370.00 €
Background

Sodium channels are integral transmemrane ion-channels that can be subdivided into voltage gated sodium channels (VGSCs) and ligand gated sodium channels (1). 9 members of the Sodium channel protein subunit alpha (Nav1.1 – Nav1.9) have been described, so far. They belong to the VGSCs that mediate the voltage-dependent sodium ion permeability of excitable membranes and contribute to initiation and propagation of action potentials (1, 2).
In mature cells Nav1.6 is the predominant subtype in axon initial segments (AIS) and nodes of Ranvier (2).
Loss of function mutations in human SCN1A encoding Nav1.1 are associated with severe epilepsy (3).