|Cat. No. 451 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.|
WB: 1 : 1000 gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: not recommended
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 1 to 45 from mouse Nav1.1 (UniProt Id: A2APX8)|
Reacts with: mouse (A2APX8), rat (P04774).
Other species not tested yet.
|Specificity||Due to high sequence homology between the N-termini of Nav1.1-Nav1.9 this antibody probably cross-reacts with other Voltage-gated sodium channel subunit alpha subtypes.|
Sodium channels are integral transmemrane ion-channels that can be subdivided into voltage gated sodium channels (VGSCs) and ligand gated sodium channels (1). 9 members of the Sodium channel protein subunit alpha (Nav1.1 – Nav1.9) have been described, so far. They belong to the VGSCs that mediate the voltage-dependent sodium ion permeability of excitable membranes and contribute to initiation and propagation of action potentials (1, 2).
In mature cells Nav1.6 is the predominant subtype in axon initial segments (AIS) and nodes of Ranvier (2).
Loss of function mutations in human SCN1A encoding Nav1.1 are associated with severe epilepsy (3).