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Home > Products > 448 003

Elfn1 antibody - 448 003 K.O.

Elfn1 is a post-synaptic protein involved in the regulation of circuit dynamics in the CNS
Rabbit polyclonal purified antibody
Cat. No.: 448 003
Amount: 50 µg
Price: $375.00
Cat. No. 448 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 629 to 719 from mouse Elfn1 (UniProt Id: Q8C8T7)
Reactivity Reacts with: mouse (Q8C8T7), rat (D3ZZ44).
Other species not tested yet.
Specificity K.O. validated PubMed: 35221979
Data sheet 448_003.pdf

References for Elfn1 - 448 003

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 448 003 IHC; tested species: mouse
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons.
Holderith N, Aldahabi M, Nusser Z
Frontiers in synaptic neuroscience (2021) 13: 773209. 448 003 IHC; KO verified; tested species: rat,mouse
Cat. No.: 448 003
Amount: 50 µg
Price: $375.00
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 448 003 IHC; tested species: mouse
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons.
Holderith N, Aldahabi M, Nusser Z
Frontiers in synaptic neuroscience (2021) 13: 773209. 448 003 IHC; KO verified; tested species: rat,mouse
WB
ICC
IHC
IHC
IHC
Background

Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1 (ELFN1) is a a postsynaptic protein that regulates circuit dynamics in the central nervous system (1) and is expressed with increasing levels during postnatal development (2).
ELFN1 is involved in the generation of facilitating synapses onto somatostatin interneurons by the recruitment of the two pre-synaptic components mGluR7 and GluK2 (2, 3).
Missense mutations of ELFN1 in the carboxy-terminal region required for mGluR7 recruitment have been observed in patients with epilepsy and attention deficit hyperactivity disorder (ADHD) (2).