|Cat. No. 442 004||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: 1 : 1000 up to 1 : 2000 gallery
IHC-P/FFPE: 1 : 1000 up to 1 : 2000 gallery
|Immunogen||Synthetic peptide corresponding to AA 275 to 297 from mouse Chil3 (UniProt Id: O35744)|
Reacts with: mouse (O35744).
Other species not tested yet.
|Specificity||Specific for murine Chil3 / YM1, shows a cross-reactivity with Chil4 (Ym2)|
|Matching control protein/peptide||442-0P|
Chitinase-3-like protein 3, also referred to as Chil 3, Ym1 and ECF-L, is a secreted protein that is primarily produced by macrophages during inflammation. It is only expressed in rodents, but expression profile and domain organization suggest a functional overlap with human AMCase and SI-CLP. Chil 3 has chemotactic activity for eosinophils, T-cells and polymorphonuclear leukocytes, and plays a role in the inflammatory response elicited by parasitic infections, lung disorders and allergy.
This lectin binds chitin, heparin and GlcN oligomers. Although Chil 3 shares homology with chitinase family proteins, it has no enzymatic activity.