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Chil3 / YM1 antibody - 442 004

Chil3/YM1 is a marker protein for murine macrophages
Polyclonal Guinea pig antiserum
Cat. No.: 442 004
Amount: 100 µl
Price: $350.00
Cat. No. 442 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 1000 up to 1 : 2000 gallery  
IHC-P/FFPE: 1 : 1000 up to 1 : 2000 gallery  
Immunogen Synthetic peptide corresponding to AA 275 to 297 from mouse Chil3 (UniProt Id: O35744)
Reactivity Reacts with: mouse (O35744).
Other species not tested yet.
Specificity Specific for murine Chil3 / YM1, shows a cross-reactivity with Chil4 (Ym2)
Matching control protein/peptide 442-0P
Data sheet 442_004.pdf

References for Chil3 / YM1 - 442 004

Abnormal brain structure and behavior in MyD88-deficient mice.
Schroeder P, Rivalan M, Zaqout S, Krüger C, Schüler J, Long M, Meisel A, Winter Y, Kaindl AM, Lehnardt S
Brain, behavior, and immunity (2020) : . 442 004 IHC; tested species: mouse
Cat. No.: 442 004
Quantity: 100 µl
Price: $350.00
Abnormal brain structure and behavior in MyD88-deficient mice.
Schroeder P, Rivalan M, Zaqout S, Krüger C, Schüler J, Long M, Meisel A, Winter Y, Kaindl AM, Lehnardt S
Brain, behavior, and immunity (2020) : . 442 004 IHC; tested species: mouse
Background

Chitinase-3-like protein 3, also referred to as Chil 3, Ym1 and ECF-L, is a secreted protein that is primarily produced by macrophages during inflammation. It is only expressed in rodents, but expression profile and domain organization suggest a functional overlap with human AMCase and SI-CLP. Chil 3 has chemotactic activity for eosinophils, T-cells and polymorphonuclear leukocytes, and plays a role in the inflammatory response elicited by parasitic infections, lung disorders and allergy.

This lectin binds chitin, heparin and GlcN oligomers. Although Chil 3 shares homology with chitinase family proteins, it has no enzymatic activity.