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Home > Products > 417 003

METTL3 antibody - 417 003 K.D.

METTL3 is a member of a N6-methyltransferase complex
Rabbit polyclonal purified antibody
Cat. No.: 417 003
Amount: 50 µg
Price: $375.00
Cat. No. 417 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 AP-staining gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 2 to 118 from mouse METTL3 (UniProt Id: Q8C3P7)
Reactivity Reacts with: mouse (Q8C3P7), human (Q86U44), rat (F7FFC6).
Other species not tested yet.
Specificity Specific for isoform 1 K.D. validated PubMed: 34108665
Data sheet 417_003.pdf

References for METTL3 - 417 003

m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis.
Cieśla M, Ngoc PCT, Muthukumar S, Todisco G, Madej M, Fritz H, Dimitriou M, Incarnato D, Hellström-Lindberg E, Bellodi C
Molecular cell (2023) 837: 1165-1179.e11. 417 003 WB; KD verified; tested species: human
RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, et al.
Cell research (2021) : . 417 003 WB; KD verified; tested species: human
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, et al.
Molecular cell (2021) 8116: 3368-3385.e9. 417 003 WB; tested species: human
Cat. No.: 417 003
Amount: 50 µg
Price: $375.00
m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis.
Cieśla M, Ngoc PCT, Muthukumar S, Todisco G, Madej M, Fritz H, Dimitriou M, Incarnato D, Hellström-Lindberg E, Bellodi C
Molecular cell (2023) 837: 1165-1179.e11. 417 003 WB; KD verified; tested species: human
RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, et al.
Cell research (2021) : . 417 003 WB; KD verified; tested species: human
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, et al.
Molecular cell (2021) 8116: 3368-3385.e9. 417 003 WB; tested species: human
WB
ICC
ICC
Background

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues of RNAs at the 5'-[AG]GAC-3' consensus sites. N6-methyladenosine (m6A) has been shown to function as an important regualtory element in many processes like the circadian clock, differentiation of embryonic stem cells, primary miRNA processing, mRNA splicing, translation efficiency, mRNA editing and stability.