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Oxytocin - 408 004

A peptide hormone with roles in childbirth and lactation, and effects on cognition and behavior
Polyclonal Guinea pig antiserum
Cat. No.: 408 004
Amount: 100 µl
Price: 350.00 €
Cat. No. 408 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 up to 1 : 750 gallery  
Immunogen Synthetic peptide corresponding to AA 20 to 28 from mouse Oxytocin-neurophysin1 (UniProt Id: P35454)
Reactivity Reacts with: mouse (P35454), rat (P01179).
Other species not tested yet.
Specificity The antibody recognizes Oxytocin. It may crossreact with the unprocessed precursor protein.
Data sheet 408_004.pdf
Cat. No.: 408 004
Quantity: 100 µl
Price: 350.00 €
Background

Oxytocin is a peptide hormone which is synthesized as an inactive precursor in nerve cell bodies in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. The precursor protein is progressively hydrolyzed to produce oxytocin and its carrier protein neurophysin I. Together with neurophysin I, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream.
Oxytocin is also produced by some neurons of the hypothalamus that project to other parts of the brain and to the spinal cord.
Oxytocin is best known for roles in female reproduction as its release causes smooth muscle contraction during parturition and lactation. It is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior.
Oxytocin is used as a medication to facilitate childbirth.