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Histidine Decarboxylase antibody - 405 003

Histidine decarboxylase is an enzyme involved in histamine synthesis
Polyclonal rabbit purified antibody
Cat. No.: 405 003
Amount: 50 µg
Price: $370.00
Cat. No. 405 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 658 from rat HDC (UniProt Id: P16453)
Reactivity Reacts with: mouse (P23738), rat (P16453).
Other species not tested yet.
Specificity Specific of histamine decarboxylase.
Data sheet 405_003.pdf
Cat. No.: 405 003
Quantity: 50 µg
Price: $370.00
Background

Histamine is synthesized by histidine decarboxylase (HDC) in many different cell types. Mast cells and basopile granulocytes store histamine in their granules that is released upon external stimulation.
In addition histamine acts as a modulatory neurotransmitter in the mammalian brain.
HDC expressing neurons occur in the tuberomammillary nucleus (TMN), which is located in the hypothalamus. It is the only site of neuronal histamine synthesis in the adult mammalian brain.