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Home > Products > 400 308

TMEM119 antibody mouse specific - 400 308

TMEM119 is a microglia specific transmembrane protein
Guinea pig monoclonal recombinant IgG
Cat. No.: 400 308
Amount: 50 µg
Price: $415.00
Cat. No. 400 308 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 2000 up to 1 : 10000 gallery  
IHC-P: 1 : 1000 up to 1 : 2000 gallery  
Clone Gp195H4
Subtype IgG2 (κ light chain)
Immunogen Recombinant protein corresponding to the C-terminal region of mouse TMEM119 (UniProt Id: Q8R138)
Reactivity Reacts with: mouse (Q8R138).
No signal: rat (B2RYL3), human (Q4V9L6).
Other species not tested yet.
Remarks

This antibody is recommended for mouse only. Due to significant differences of TMEM119 among species, cross-reactivity is unlikely.
The antibody is a chimeric antibody based on the monoclonal mouse antibody clone 195H4. The constant regions of the heavy and light chains have been replaced by guinea pig specific sequences. Therefore, the antibody can be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells.
Data sheet 400_308.pdf
Cat. No.: 400 308
Amount: 50 µg
Price: $415.00
IHC
IHC
IHC-P
Background
Microglia are resident myeloid cells of the central nervous system (CNS). They are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions. Transmembrane protein 119 (TMEM 119) is a single-pass type I membrane protein that has been identified as a useful, highly selective microglia marker protein.
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