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TMEM119 antibody - 400 011

TMEM119 is a microglia specific transmembrane protein
Monoclonal mouse purified IgG
Cat. No.: 400 011
Amount: 100 µg
Price: $425.00
Cat. No. 400 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 100 up to 1 : 200 gallery  
Clone 195H4
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 189 to 280 from mouse TMEM119 (UniProt Id: Q8R138)
Epitop Epitop: AA 189 to 280 from mouse TMEM119 (UniProt Id: Q8R138)
Reactivity Reacts with: mouse (Q8R138).
No signal: rat (B2RYL3), human (Q4V9L6).
Other species not tested yet.
Specificity specific for TMEM119
Remarks

This antibody is recommended for mouse only. Due to significant differences of TMEM 119 among species, cross-reactivity is unlikely.

Data sheet 400_011.pdf

References for TMEM119 - 400 011

Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP/PS1-transgenic mice.
Quan W, Luo Q, Hao W, Tomic I, Furihata T, Schulz-Schäffer W, Menger MD, Fassbender K, Liu Y
Glia (2021) : . 400 011 IHC; tested species: mouse
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model.
Anzilotti S, Valsecchi V, Brancaccio P, Guida N, Laudati G, Tedeschi V, Petrozziello T, Frecentese F, Magli E, Hassler B, Cuomo O, et al.
Neurobiology of disease (2021) 159: 105480. 400 011 IHC; tested species: mouse
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Kim T, Chokkalla AK, Vemuganti R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2020) : 271678X20943804. 400 011 IHC; tested species: mouse
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, et al.
Nature communications (2019) 101: 5816. 400 011 IHC; tested species: mouse
Cat. No.: 400 011
Quantity: 100 µg
Price: $425.00
Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP/PS1-transgenic mice.
Quan W, Luo Q, Hao W, Tomic I, Furihata T, Schulz-Schäffer W, Menger MD, Fassbender K, Liu Y
Glia (2021) : . 400 011 IHC; tested species: mouse
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model.
Anzilotti S, Valsecchi V, Brancaccio P, Guida N, Laudati G, Tedeschi V, Petrozziello T, Frecentese F, Magli E, Hassler B, Cuomo O, et al.
Neurobiology of disease (2021) 159: 105480. 400 011 IHC; tested species: mouse
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Kim T, Chokkalla AK, Vemuganti R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2020) : 271678X20943804. 400 011 IHC; tested species: mouse
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, et al.
Nature communications (2019) 101: 5816. 400 011 IHC; tested species: mouse
Background
Microglia are resident myeloid cells of the central nervous system (CNS). They are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions. Transmembrane protein 119 (TMEM 119) is a single-pass type I membrane protein that has been identified as a useful, highly selective microglia marker protein.