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TMEM119 antibody - 400 008

TMEM119 is a microglia specific transmembrane protein
Monoclonal Recombinant rabbit recombinant IgG
Cat. No.: 400 008
Amount: 50 µg
Price: $415.00
Cat. No. 400 008 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 2000 up to 1 : 10000 gallery  
IHC-P/FFPE: 1 : 1000 up to 1 : 5000 gallery  
Clone Rb195H4
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 189 to 280 from mouse TMEM119 (UniProt Id: Q8R138)
Reactivity Reacts with: mouse (Q8R138).
No signal: rat (B2RYL3), human (Q4V9L6).
Other species not tested yet.
Specificity Specific for TMEM119
Remarks

This antibody is recommended for mouse only. Due to significant differences of TMEM 119 among species, cross-reactivity is unlikely.
The antibody is a chimeric antibody based on the monoclonal mouse antibody clone 195H4. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 400_008.pdf
Cat. No.: 400 008
Quantity: 50 µg
Price: $415.00
Background
Microglia are resident myeloid cells of the central nervous system (CNS). They are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions. Transmembrane protein 119 (TMEM 119) is a single-pass type I membrane protein that has been identified as a useful, highly selective microglia marker protein.