Tailor-made Antibodies
and Tools for Live Science
Home|||||||Technical Support|

TMEM119 antibody - 400 002

TMEM119 is a microglia specific transmembrane protein
Polyclonal rabbit antiserum
Cat. No.: 400 002
Amount: 200 µl
Price: $350.00
Cat. No. 400 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC-P/FFPE: 1 : 500      gallery  
Immunogen Recombinant protein corresponding to AA 189 to 280 from mouse TMEM119 (UniProt Id: Q8R138)
Reactivity Reacts with: mouse (Q8R138).
Weaker signal: rat (B2RYL3).
Other species not tested yet.
Specificity Specific for TMEM 119.
Remarks

This antibody is recommended for mouse only. Due to significant differences of TMEM 119 among species, cross-reactivity is unlikely.
IHC: The antiserum produces some unspecific background in the cerebellum.

Data sheet 400_002.pdf

References for TMEM119 - 400 002

Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma.
Pasquettaz R, Kolotuev I, Rohrbach A, Gouelle C, Pellerin L, Langlet F
The Journal of comparative neurology (2021) 5293: 553-575. 400 002 IHC; tested species: mouse
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, Gruber M, Koch J, Hausmann A, Zhang P, Boneva S, et al.
The EMBO journal (2021) 406: e105123. 400 002 IHC; tested species: mouse
Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization.
Kim J, Kim JH, Do JY, Lee JY, Yanai R, Lee IK, Suk K, Park DH
Frontiers in cellular neuroscience (2021) 15: 638098. 400 002 IHC; tested species: mouse
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, et al.
Glia (2020) : . 400 002 IHC; tested species: mouse
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201900337R. 400 002 IHC; tested species: mouse
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.
Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow S, Glatzel M, Krasemann S
Acta neuropathologica communications (2019) 71: 83. 400 002 IHC; tested species: mouse
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study.
Su N, März S, Plagemann T, Cao J, Schnittler HJ, Eter N, Heiduschka P
Translational vision science & technology (2019) 86: 29. 400 002 IHC; tested species: mouse
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis.
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, Tröscher AR, Kitic M, Ueda S, Bradl M, Lassmann H, et al.
Acta neuropathologica communications (2019) 71: 14. 400 002 IHC-P; tested species: rat
Cat. No.: 400 002
Quantity: 200 µl
Price: $350.00
Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma.
Pasquettaz R, Kolotuev I, Rohrbach A, Gouelle C, Pellerin L, Langlet F
The Journal of comparative neurology (2021) 5293: 553-575. 400 002 IHC; tested species: mouse
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, Gruber M, Koch J, Hausmann A, Zhang P, Boneva S, et al.
The EMBO journal (2021) 406: e105123. 400 002 IHC; tested species: mouse
Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization.
Kim J, Kim JH, Do JY, Lee JY, Yanai R, Lee IK, Suk K, Park DH
Frontiers in cellular neuroscience (2021) 15: 638098. 400 002 IHC; tested species: mouse
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, et al.
Glia (2020) : . 400 002 IHC; tested species: mouse
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201900337R. 400 002 IHC; tested species: mouse
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.
Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow S, Glatzel M, Krasemann S
Acta neuropathologica communications (2019) 71: 83. 400 002 IHC; tested species: mouse
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study.
Su N, März S, Plagemann T, Cao J, Schnittler HJ, Eter N, Heiduschka P
Translational vision science & technology (2019) 86: 29. 400 002 IHC; tested species: mouse
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis.
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, Tröscher AR, Kitic M, Ueda S, Bradl M, Lassmann H, et al.
Acta neuropathologica communications (2019) 71: 14. 400 002 IHC-P; tested species: rat
Background
Microglia are resident myeloid cells of the central nervous system (CNS). They are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions. Transmembrane protein 119 (TMEM 119) is a single-pass type I membrane protein that has been identified as a useful, highly selective microglia marker protein.