Cat. No.: 391 008
Amount: 50 µg
Price:
$420.00
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| Cat. No. 391 008 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb325C4 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to C-terminal residues of mouse LAMP3 (UniProt Id: Q7TST5) |
| Reactivity |
Reacts with: mouse (Q7TST5), rat (Q5XI99). Other species not tested yet. |
| Specificity | K.O. validated |
| Remarks |
This antibody is a chimeric antibody based on a monoclonal rat antibody. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 391_008.pdf |
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LAMP3-staining (red) in type II pneumocytes in a mouse lung section
LAMP3 (lysosome-associated membrane glycoprotein 3), also referred to as DC-LAMP (dendritic cell LAMP) or CD 208, is a member of the LAMP protein family and a single-pass type I transmembrane protein that can be variably glycosylated. It is specifically expressed in lung type II pneumocytes and by activated human dendritic cells (1, 2).
Recent studies demonstrated high expression of LAMP3 in a variety of malignancies including squamous cell carcinoma, gastrointestinal cancer, breast cancer, ovarian cancer, and cervical cancer. Its expression has been associated with metastasis and poor overall survival (3, 4, 5).