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Home > Products > 389 004

Orexin A antibody - 389 004 K.O.

Orexins regulate feeding, sleep, arousal, reward seeking and energy homeostasis
Guinea pig polyclonal antiserum
Cat. No.: 389 004
Amount: 100 µl
Price: $365.00
Cat. No. 389 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500      gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 46 to 65 from mouse Orexin (UniProt Id: O55241)
Reactivity Reacts with: human, rat, mouse (O55241).
Other species not tested yet.
Specificity Recognizes Orexin A with only minor cross-reactivity to the unprocessed precursor protein. Does not cross-react to Orexin B. K.O. validated
Data sheet 389_004.pdf

References for Orexin A - 389 004

Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation.
Kaneko T, Kuwaki T, Kashiwadani H
The journal of physiological sciences : JPS (2022) 721: 21. 389 004 IHC; tested species: mouse
Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response.
Kuwaki T
Peptides (2021) 139: 170530. 389 004 IHC; tested species: mouse
Cat. No.: 389 004
Amount: 100 µl
Price: $365.00
Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation.
Kaneko T, Kuwaki T, Kashiwadani H
The journal of physiological sciences : JPS (2022) 721: 21. 389 004 IHC; tested species: mouse
Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response.
Kuwaki T
Peptides (2021) 139: 170530. 389 004 IHC; tested species: mouse
IHC
IHC
IHC-P
Background
Orexins, also referred to as Hypocretins, are produced by specialized neurons in the lateral hypothalamus, which project to many different regions of the brain. Orexin A (33 amino acids) and Orexin B (28 amino acids) are both produced from a single pre-pro-orexin polypeptide by a cascade of enzymatic reactions. They operate via binding to two closely related G protein-coupled receptors called Orexin receptor 1 and 2 (OxR 1 and OxR 2). OxR 1 is selective for Orexin A whereas OxR 2 binds both peptides with similar affinity.
The orexin system is conserved in mammals, and plays a central role in regulating feeding, sleep/wake cycles, arousal, energy expenditure, reward seeking, cognition, and stress responses. Defects in orexin signaling are involved in diet-induced obesity, diabetes, narcolepsy, panic anxiety disorder, depression, and addiction.