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Home > Products > 377 003

TRIM46 antibody - 377 003

TRIM46 is involved in establishing neuronal polarity
Rabbit polyclonal purified antibody
Cat. No.: 377 003
Amount: 50 µg
Price: $375.00
Cat. No. 377 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 561 from rat Trim46 (UniProt Id: A0A0G2JXN2)
Reactivity Reacts with: rat (A0A0G2JXN2), mouse (Q7TNM2).
Other species not tested yet.
Remarks

IHC: For optimal signal to noise ratio, we recommend our recombinant rabbit TRIM46 antibody 377 008
Data sheet 377_003.pdf

References for TRIM46 - 377 003

Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 003 ICC; tested species: human,rat
Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
Developmental cell (2021) : . 377 003 ICC; tested species: rat
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Bell M, Bachmann S, Klimek J, Langerscheidt F, Zempel H
Neuroscience (2021) 461: 155-171. 377 003 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 377 003 ICC; tested species: rat
Cat. No.: 377 003
Amount: 50 µg
Price: $375.00
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 003 ICC; tested species: human,rat
Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
Developmental cell (2021) : . 377 003 ICC; tested species: rat
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Bell M, Bachmann S, Klimek J, Langerscheidt F, Zempel H
Neuroscience (2021) 461: 155-171. 377 003 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 377 003 ICC; tested species: rat
ICC
IHC
IHC-P
Background
The tripartite motif containing protein TRIM 46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily.
TRIM 46 localizes to newly specified axons and, at later stages, to the axon initial segment (AIS). By forming closely spaced parallel microtubule bundles it plays a crucial role in the initial polarization of neuronal cells.
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