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Tryptophan hydroxylase2 antibody - 348 011 K.O.

Tryptophan hydroxylase2 is an enzyme involved in serotonin synthesis
Mouse monoclonal purified IgG
Cat. No.: 348 011
Amount: 100 µg
Price: $415.00
Cat. No. 348 011 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: not tested yet
IHC: 1 : 100 up to 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Clone 269E7
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 139 from rat Tryptophanhydroxylase 2 (UniProt Id: Q8CGU9)
Reactivity Reacts with: rat (Q8CGU9), mouse (Q8CGV2).
Other species not tested yet.
Specificity K.O. validated
Data sheet 348_011.pdf
Cat. No.: 348 011
Amount: 100 µg
Price: $415.00
Background
Tryptophan hydroxylase (TPH) is an enzyme that catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).
Two isoforms TPH 1 and TPH 2 have been described. TPH 1 occurs mainly in tissues that express serotonin in the periphery (skin, gut, pineal gland). TPH 2 is exclusively expressed in neuronal cell types and is the predominant isoform in the central nervous system.
In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain.