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SATB2 antibody - 327 004

SATB2 is a transcription factor involved in neuronal differentiation
Guinea pig polyclonal antiserum
Cat. No.: 327 004
Amount: 100 µl
Price: $365.00
Cat. No. 327 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 718 to 733 from mouse SATB2 (UniProt Id: Q8VI24)
Reactivity Reacts with: rat (D3ZJ19), mouse (Q8VI24).
Other species not tested yet.
Data sheet 327_004.pdf

References for SATB2 - 327 004

iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A
Nature communications (2024) 151: 827. 327 004 IHC; tested species: human
KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury.
Lai JD, Berlind JE, Fricklas G, Lie C, Urenda JP, Lam K, Sta Maria N, Jacobs R, Yu V, Zhao Z, Ichida JK, et al.
Cell stem cell (2024) 314: 519-536.e8. 327 004 IHC; tested species: human
Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.
Liau ES, Jin S, Chen YC, Liu WS, Calon M, Nedelec S, Nie Q, Chen JA
Nature communications (2023) 141: 46. 327 004 IHC; tested species: mouse
MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs.
Chang SH, Su YC, Chang M, Chen JA
eLife (2021) 10: . 327 004 IHC; tested species: mouse
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.
Okaty BW, Sturrock N, Escobedo Lozoya Y, Chang Y, Senft RA, Lyon KA, Alekseyenko OV, Dymecki SM
eLife (2020) 9: . 327 004 IHC; tested species: mouse
Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex.
Mattugini N, Bocchi R, Scheuss V, Russo GL, Torper O, Lao CL, Götz M
Neuron (2019) : . 327 004 IHC; tested species: mouse
Cat. No.: 327 004
Amount: 100 µl
Price: $365.00
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A
Nature communications (2024) 151: 827. 327 004 IHC; tested species: human
KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury.
Lai JD, Berlind JE, Fricklas G, Lie C, Urenda JP, Lam K, Sta Maria N, Jacobs R, Yu V, Zhao Z, Ichida JK, et al.
Cell stem cell (2024) 314: 519-536.e8. 327 004 IHC; tested species: human
Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.
Liau ES, Jin S, Chen YC, Liu WS, Calon M, Nedelec S, Nie Q, Chen JA
Nature communications (2023) 141: 46. 327 004 IHC; tested species: mouse
MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs.
Chang SH, Su YC, Chang M, Chen JA
eLife (2021) 10: . 327 004 IHC; tested species: mouse
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.
Okaty BW, Sturrock N, Escobedo Lozoya Y, Chang Y, Senft RA, Lyon KA, Alekseyenko OV, Dymecki SM
eLife (2020) 9: . 327 004 IHC; tested species: mouse
Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex.
Mattugini N, Bocchi R, Scheuss V, Russo GL, Torper O, Lao CL, Götz M
Neuron (2019) : . 327 004 IHC; tested species: mouse
Background

The Special AT-rich sequence-binding protein 2 or SATB 2 is a transcription factor required for the initiation of the genetic program for the upper-layer neurons (UL1).
Together with Ctip 2, Coup-TFI, and Fezf 2 it is involved in the fine tuned sequential formation and specification of the different excitatory neuron populations forming the definitive six-layered cortical structure.