Cat. No.: 326 008
Amount: 50 µg
Price:
$420.00
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| Cat. No. 326 008 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb179B7 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse Doublecortin (UniProt Id: Q6PGI2) |
| Reactivity |
Reacts with: mouse (O88809), rat (Q9ESI7), human (O43602). Other species not tested yet. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal rat antibody clone SY-179B7. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 326_008.pdf |
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Doublecortin (red) and β3-Tubulin (green) staining in the dentate gyrus of a mouse hippocampus section
Doublecortin or DCX seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. Mutations in the gene encoding this protein have been linked to the double cortex syndrome.
Doublecortin is highly expressed in neuronal cells of fetal brain but absent from other tissues. In the adult dentate gyrus it is only expressed in cells contributing to adult neurogenesis.
For more information on protein expression pattern, please refer to the overview image in our SYSY Antibodies ATLAS.