Tailor-made Antibodies
and Tools for Life Science
Home|||||||Technical Support|

Doublecortin antibody - 326 004

Doublecortin or DCX is a protein associated with neuronal differentiation
Guinea pig polyclonal antiserum
Cat. No.: 326 004
Amount: 100 µl
Price: $350.00
Cat. No. 326 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended
IHC: not recommended
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 271 to 366 from mouse Doublecortin (UniProt Id: Q6PGI2)
Reactivity Reacts with: rat (Q9ESI7), mouse (Q6PGI2).
Other species not tested yet.
Specificity Specific for doublecortin.
Data sheet 326_004.pdf

References for Doublecortin - 326 004

Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids.
Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, de Amorim VCM, Rossi A, Chrzanowska KH, Adjaye J
Cells (2022) 115: . 326 004 IHC; tested species: human
Cat. No.: 326 004
Amount: 100 µl
Price: $350.00
Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids.
Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, de Amorim VCM, Rossi A, Chrzanowska KH, Adjaye J
Cells (2022) 115: . 326 004 IHC; tested species: human
Background
Doublecortin or DCX seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. Mutations in the gene encoding this protein have been linked to the double cortex syndrome.
Doublecortin is highly expressed in neuronal cells of fetal brain but absent from other tissues. In the adult dentate gyrus it is only expressed in cells contributing to adult neurogenesis.