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Tau - 314 004

A microtubule associated protein
Polyclonal Guinea pig antiserum
Cat. No.: 314 004
Amount: 100 µl
Price: 350.00 €
Cat. No. 314 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 3 to 214 from mouse Tau (UniProt Id: P10637)
Reactivity Reacts with: rat (P19332), mouse (P10637).
Weaker signal: human (P10636).
No signal: chicken.
Other species not tested yet.
Specificity Specific for tau.
Matching control protein/peptide 314-0P
Remarks The antibody binds phosphorylated and non-phosphorylated tau proteins.
Data sheet 314_004.pdf

References for Tau - 314 004

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C
Stem cell research (2018) 27: 121-130. 314 004 WB; tested species: human
Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth.
Ho CF, Ismail NB, Koh JK, Gunaseelan S, Low YH, Ng YK, Chua JJ, Ong WY
Neurochemical research (2018) 438: 1587-1598. 314 004 ICC; tested species: rat
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 314 004 ICC; tested species: human
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW
Nature protocols (2016) 1110: 1877-88. 314 004 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 314 004 ICC
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 314 004 ICC; tested species: mouse
Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments.
Howard PW, Howard TL, Johnson DC
Journal of virology (2013) 871: 403-14. 314 004 ICC
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 314 004 ICC; tested species: mouse
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 314 004 ICC; tested species: mouse
Facilitation of neocortical presynaptic terminal development by NMDA receptor activation.
Sceniak MP, Berry CT, Sabo SL
Neural development (2012) 7: 8. 314 004 ICC
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 314 004 IHC
Cat. No.: 314 004
Quantity: 100 µl
Price: 350.00 €
Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C
Stem cell research (2018) 27: 121-130. 314 004 WB; tested species: human
Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth.
Ho CF, Ismail NB, Koh JK, Gunaseelan S, Low YH, Ng YK, Chua JJ, Ong WY
Neurochemical research (2018) 438: 1587-1598. 314 004 ICC; tested species: rat
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 314 004 ICC; tested species: human
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW
Nature protocols (2016) 1110: 1877-88. 314 004 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 314 004 ICC
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 314 004 ICC; tested species: mouse
Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments.
Howard PW, Howard TL, Johnson DC
Journal of virology (2013) 871: 403-14. 314 004 ICC
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 314 004 ICC; tested species: mouse
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 314 004 ICC; tested species: mouse
Facilitation of neocortical presynaptic terminal development by NMDA receptor activation.
Sceniak MP, Berry CT, Sabo SL
Neural development (2012) 7: 8. 314 004 ICC
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 314 004 IHC
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.