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Tau antibody - 314 003

Tau is a neuronal microtubule associated protein
Rabbit polyclonal purified antibody
Cat. No.: 314 003
Amount: 50 µg
Price: $455.00
Cat. No. 314 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: yes
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of mouse Tau-D (UniProt Id: P10637-5)
Reactivity Reacts with: rat (P19332), mouse (P10637).
Weaker signal: human (P10636).
No signal: chicken.
Other species not tested yet.
Specificity This antibody binds phosphorylated and non-phosphorylated tau proteins. The sequence used for immunization is present in all splice variants except human TauA (UniProt Id: P10636-3).
Matching control protein/peptide 314-0P
Remarks

For human tissue cat.no. 314 012 and 314 111 are highly recommended.

Data sheet 314_003.pdf

References for Tau - 314 003

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, et al.
Cell reports (2019) 288: 2111-2123.e6. 314 003 WB; tested species: human
Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.
Gill I, Droubi S, Giovedi S, Fedder KN, Bury LA, Bosco F, Sceniak MP, Benfenati F, Sabo SL
Journal of cell science (2015) 1284: 768-80. 314 003 ICC
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 314 003 ICC
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
Schildknecht S, Karreman C, Pöltl D, Efrémova L, Kullmann C, Gutbier S, Krug A, Scholz D, Gerding HR, Leist M
ALTEX (2013) 304: 427-44. 314 003 ICC
Cat. No.: 314 003
Amount: 50 µg
Price: $455.00
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, et al.
Cell reports (2019) 288: 2111-2123.e6. 314 003 WB; tested species: human
Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.
Gill I, Droubi S, Giovedi S, Fedder KN, Bury LA, Bosco F, Sceniak MP, Benfenati F, Sabo SL
Journal of cell science (2015) 1284: 768-80. 314 003 ICC
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 314 003 ICC
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
Schildknecht S, Karreman C, Pöltl D, Efrémova L, Kullmann C, Gutbier S, Krug A, Scholz D, Gerding HR, Leist M
ALTEX (2013) 304: 427-44. 314 003 ICC
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.