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beta-Catenin antibody - 281 004

Cadherin binding partners
Polyclonal Guinea pig antiserum
Cat. No.: 281 004
Amount: 100 µl
Price: $350.00
Cat. No. 281 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000      gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 768 to 782 from mouse β-Catenin (UniProt Id: Q02248)
Reactivity Reacts with: rat (Q9WU82), mouse (Q02248).
Other species not tested yet.
Specificity Specific for β-catenin
Matching control protein/peptide 281-0P
Data sheet 281_004.pdf

References for beta-Catenin - 281 004

A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 281 004 IHC; tested species: rat
Cat. No.: 281 004
Quantity: 100 µl
Price: $350.00
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 281 004 IHC; tested species: rat
Background
α, β and γ-catenin are intracellular proteins that link cadherins to the actin cytosceleton. Cadherins are cell-surface proteins that are involved in cell-cell adhesion.
α-N-catenin is expressed mainly in the nervous system. It is a cytoplasmic protein that interacts with N-cadherin and functions in cell-cell adhesion. It is a regulator for the stability of synaptic contacts and is important for cerebellar and hippocampal lamination. There are two isoforms which are differentially expressed during development.
The major part of β-catenin localizes to the cell membrane and is part of E-cadherin/catenin adhesion complexes.