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UCHL 1 antibody - 233 003

UCHL1 or PGP9.5 is a neuron specific member of the ubiquitin proteasome system.
Polyclonal rabbit purified antibody
Cat. No.: 233 003
Amount: 50 µg
Price: $450.00
Cat. No. 233 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: yes gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 6 to 223 from rat UCHL1 (UniProt Id: Q00981)
Reactivity Reacts with: rat (Q00981), mouse (Q9R0P9).
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for UCHL 1
Data sheet 233_003.pdf
Cat. No.: 233 003
Quantity: 50 µg
Price: $450.00
Background
The Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL 1) enzyme is a member of a protein family involved in the hydrolyzation of C-terminal adducts of polymeric ubiquitin to generate monomeric ubiquitin. It is abundantly expressed in neurons throughout the brain and belongs to the ubiquitin-proteasome system. This pathway is responsible for the degradation of misfolded and damaged proteins and has been postulated to play an important role in Parkinson's disease.