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mGluR2 peptide - 191-1P

mGluRs are metabotropic glutamate receptors involved in excitatory neurotransmission
control peptide
Cat. No.: 191-1P
Amount: 100 µg
Price: $105.00
Cat. No. 191-1P 100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Control peptides should be stored at -20°C when still lyophilized!
Applications
 
Immunogen Synthetic peptide corresponding to AA 837 to 853 from rat mGluR2 (UniProt Id: P31421)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 191 103
Remarks

This control peptide consists of the synthetic peptide (aa 837-853) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 191-1p.pdf
Cat. No.: 191-1P
Amount: 100 µg
Price: $105.00
Background

Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1 - 8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).

Protocols