Cat. No.: 184 002
Amount: 200 µl
Price:
$355.00
|
|
|
| Cat. No. 184 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 1 to 232 from rat Velis1 (UniProt Id: Q9Z250) |
| Reactivity |
Reacts with: human (O14910, Q9HAP6, Q9NUP9), rat (Q9Z250, Q9Z252, Q792I0), mouse (Q8JZS0, O88951, O88952). Other species not tested yet. |
| Specificity | Recognizes all three isoforms veli 1, 2 and 3. |
| Matching control protein/peptide | 184-0P |
| Data sheet | 184_002.pdf |
|
|
The complex of the multi-adaptor-proteins CASK, Mint and Veli, also referred to as MALS and Lin 7, is conserved across kingdoms and may be involved in localizing synaptic vesicles at synaptic terminals. Three Veli isoforms (1, 2 and 3) with different expression patterns have been described, so far.
Veli proteins have also been suggested to participate in regulating the recruitment of neurotransmitter receptors to the post synaptic density (PSD) by interaction with their PDZ domains.