Tailor-made Antibodies
and Tools for Life Science
Home|||||Technical Support

GluK5 antibody - 180 103

GluKs are ligand-gated ion channel involved in excitatory neurotransmission
Rabbit polyclonal purified antibody
Cat. No.: 180 103
Amount: 50 µg
Price: $375.00
Cat. No. 180 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC-P: not tested yet
IHC-Fr: 1 : 1000 (see remarks) gallery  
Immunogen Recombinant protein corresponding to AA 828 to 979 from rat GluK5 (UniProt Id: Q63273)
Reactivity Reacts with: rat (Q63273), mouse (Q61626).
Other species not tested yet.
Matching control protein/peptide 180-1P
Remarks

IHC-Fr: Antibody requires Clarke liquid fixation (1 vol. acetic acid, 6 vol. ethanol, 15 min at RT).

Data sheet 180_103.pdf

References for GluK5 - 180 103

Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
Marrocco J, Mairesse J, Ngomba RT, Silletti V, Van Camp G, Bouwalerh H, Summa M, Pittaluga A, Nicoletti F, Maccari S, Morley-Fletcher S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3248: 17143-54. 180 103 WB
Localization of kainate receptors in inner and outer hair cell synapses.
Fujikawa T, Petralia RS, Fitzgerald TS, Wang YX, Millis B, Morgado-Díaz JA, Kitamura K, Kachar B
Hearing research (2014) 314: 20-32. 180 103 IHC; tested species: rat
Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4249: 9253-9262. 180 103 IHC-Fr; tested species: mouse
Cat. No.: 180 103
Amount: 50 µg
Price: $375.00
Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
Marrocco J, Mairesse J, Ngomba RT, Silletti V, Van Camp G, Bouwalerh H, Summa M, Pittaluga A, Nicoletti F, Maccari S, Morley-Fletcher S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3248: 17143-54. 180 103 WB
Localization of kainate receptors in inner and outer hair cell synapses.
Fujikawa T, Petralia RS, Fitzgerald TS, Wang YX, Millis B, Morgado-Díaz JA, Kitamura K, Kachar B
Hearing research (2014) 314: 20-32. 180 103 IHC; tested species: rat
Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4249: 9253-9262. 180 103 IHC-Fr; tested species: mouse
Background

Ionotropic glutamate receptors (iGluRs) mediate rapid excitatory neurotransmission in the mammalian CNS. They can be subdivided into three major groups, the AMPA/GluA, NMDA/GluN, and kainate/GluK receptors (KARs) (1, 2).
mRNAs coding for glutamate receptors are substrates for an adenosine deaminase acting on RNA (ADAR) that increases the diversity of these proteins (3). KARs can be found at pre- and postsynaptic sites and are composed of five different subunits: GluK1, GluK2 and GluK3 can form homomeric receptors whereas GluK4 and GluK5 form heteromeric receptors with GluK1-3 (4).