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Liprin-alpha3 antibody - 169 002

Liprin-alpha3 is involved in the development of presynaptic active zones
Rabbit polyclonal antiserum
Cat. No.: 169 002
Amount: 200 µl
Price: $350.00
Cat. No. 169 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 313 to 461 from mouse Liprin-α3 (UniProt Id: P60469)
Reactivity Reacts with: human (O75145), rat (Q91Z79), mouse (P60469).
No signal: zebrafish.
Other species not tested yet.
Specificity This antibody probably cross reacts to isoforms 1, 2, 4, due to sequence homologies.
Matching control protein/peptide 169-0P
Data sheet 169_002.pdf

References for Liprin-alpha3 - 169 002

Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 169 002 WB
Cat. No.: 169 002
Amount: 200 µl
Price: $350.00
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 169 002 WB
Background

The liprin-α/Syd 2 protein family was initially identified as binding partners of the LAR family of receptor protein-tyrosine phosphatases.
Liprin-α proteins are multidomain proteins which are involved in the development of presynaptic active zones. Four isoforms of liprin-α have been described, so far and all of them interact with the RIM binding partners ERC 1b and ERC 2.
All four isoforms of liprin-α have also been identified as members of the MALS complex composed of CASK, Mint1 and Velis. This complex has been reported to be crucial for synaptic vesicle exocytosis.