|Cat. No. 162 204||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 1000 up to 1 : 2000 gallery
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 500
|Immunogen||Recombinant protein corresponding to AA 1042 to 1475 from rat Shank2 (UniProt Id: Q9QX74)|
Reacts with: rat (Q9QX74), mouse (Q80Z38).
Other species not tested yet.
|Specificity||Specific for shank 2. K.O. PubMed: 29970987|
Shank 1, 2 and 3 are major proteins of the postsynaptic density (PSD). They are composed of several protein-protein interaction domains like PDZ-, homer- and ABP 1-binding domains which allow them to crosslink ionotopic and metabotropic glutamate receptor complexes with each other and to the actin-cytoskeleton.