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Homer 2 antibody - 160 203

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit polyclonal purified antibody
Cat. No.: 160 203
Amount: 50 µg
Price: $370.00
Cat. No. 160 203 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 176 from rat Homer2 (UniProt Id: O88801)
Reactivity Reacts with: rat (O88801), mouse (Q9QWW1).
Other species not tested yet.
Specificity AA 121-176, unique for homer 2, were used for affinity purification.
Data sheet 160_203.pdf

References for Homer 2 - 160 203

Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration.
Gobin C, Shallcross J, Schwendt M
Neurobiology of learning and memory (2019) : . 160 203 WB; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 203 WB, EM
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 160 203 ICC; tested species: mouse
In utero Δ9-tetrahydrocannabinol exposure confers vulnerability towards cognitive impairments and alcohol drinking in the adolescent offspring: Is there a role for neuropeptide Y?
Brancato A, Castelli V, Lavanco G, Marino RAM, Cannizzaro C
Journal of psychopharmacology (Oxford, England) (2020) : 269881120916135. 160 203 IHC; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 203 WB, EM
Cat. No.: 160 203
Amount: 50 µg
Price: $370.00
Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration.
Gobin C, Shallcross J, Schwendt M
Neurobiology of learning and memory (2019) : . 160 203 WB; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 203 WB, EM
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 160 203 ICC; tested species: mouse
In utero Δ9-tetrahydrocannabinol exposure confers vulnerability towards cognitive impairments and alcohol drinking in the adolescent offspring: Is there a role for neuropeptide Y?
Brancato A, Castelli V, Lavanco G, Marino RAM, Cannizzaro C
Journal of psychopharmacology (Oxford, England) (2020) : 269881120916135. 160 203 IHC; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 203 WB, EM
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, Homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.