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Home > Products > 154 003

CSP antibody - 154 003 K.O.

CSP is a chaperon at the synapse
Rabbit polyclonal purified antibody
Cat. No.: 154 003
Amount: 50 µg
Price: $375.00
Cat. No. 154 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 1000 gallery  
IHC: yes gallery  
IHC-P: yes
Immunogen Synthetic peptide corresponding to AA 182 to 198 from rat CSP (UniProt Id: P60905)
Reactivity Reacts with: human (Q9H3Z4), rat (P60905), mouse (P60904), cow, dog, chicken.
Other species not tested yet.
Specificity K.O. validated PubMed: 27881461
Data sheet 154_003.pdf

References for CSP - 154 003

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, et al.
Molecular systems biology (2018) 147: e8071. 154 003 WB, ICC; tested species: mouse
Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.
Gregg BE, Botezatu N, Brill JD, Hafner H, Vadrevu S, Satin LS, Alejandro EU, Bernal-Mizrachi E
Scientific reports (2018) 81: 5745. 154 003 WB; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 154 003 WB, ICC; KO verified; tested species: mouse
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31. 154 003 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R
The Journal of comparative neurology (2008) 5065: 822-37. 154 003 WB, IHC
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, et al.
Molecular systems biology (2018) 147: e8071. 154 003 WB, ICC; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 154 003 WB, ICC; KO verified; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.
García-Junco-Clemente P, Cantero G, Gómez-Sánchez L, Linares-Clemente P, Martínez-López JA, Luján R, Fernández-Chacón R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3021: 7377-91. 154 003 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum.
Sharrad DF, Gai WP, Brookes SJ
The Journal of comparative neurology (2013) 52111: 2523-37. 154 003 IHC
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3127: 10076-87. 154 003 IHC
Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R
The Journal of comparative neurology (2008) 5065: 822-37. 154 003 WB, IHC
Cat. No.: 154 003
Amount: 50 µg
Price: $375.00
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, et al.
Molecular systems biology (2018) 147: e8071. 154 003 WB, ICC; tested species: mouse
Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.
Gregg BE, Botezatu N, Brill JD, Hafner H, Vadrevu S, Satin LS, Alejandro EU, Bernal-Mizrachi E
Scientific reports (2018) 81: 5745. 154 003 WB; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 154 003 WB, ICC; KO verified; tested species: mouse
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31. 154 003 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R
The Journal of comparative neurology (2008) 5065: 822-37. 154 003 WB, IHC
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, et al.
Molecular systems biology (2018) 147: e8071. 154 003 WB, ICC; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 154 003 WB, ICC; KO verified; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.
García-Junco-Clemente P, Cantero G, Gómez-Sánchez L, Linares-Clemente P, Martínez-López JA, Luján R, Fernández-Chacón R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3021: 7377-91. 154 003 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 154 003 WB, ICC, IHC; tested species: mouse,rat
Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum.
Sharrad DF, Gai WP, Brookes SJ
The Journal of comparative neurology (2013) 52111: 2523-37. 154 003 IHC
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3127: 10076-87. 154 003 IHC
Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R
The Journal of comparative neurology (2008) 5065: 822-37. 154 003 WB, IHC
WB
ICC
IHC
Background

Cysteine String Proteins CSPs are composed of an N-terminal J-domain and a central palmitoylated cysteine string. This post-translational modification shifts the molecular weight of CSP 1 in brain from 23 kDa to 34 kDa and confers membrane targeting of the protein.
CSP has been initially identified as a synaptic vesicle protein which is involved in Ca2+ triggered neurotransmitter release. Later CSP was also found on Large Dense Core Vesicles (LDCVs) of pancreatic insulin secretory β-cells, chromaffin cells and adipocytes. It has been shown to interact with SNARE proteins like VAMP 2, VAMP 7 and syntaxin 4.
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