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Home > Products > 147 103

Gephyrin antibody - 147 103

Gephyrin is a scaffolding protein associated with inhibitory neurotransmitter receptors
Rabbit polyclonal purified antibody
Cat. No.: 147 103
Amount: 50 µg
Price: $375.00
Cat. No. 147 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 294 to 736 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: rat (Q03555), mouse (Q8BUV3).
Other species not tested yet.
Matching control protein/peptide 147-1P
Remarks

IP: For most effective IP, use the denaturing IP-protocol. Consider that protein-protein interactions may be affected.
Data sheet 147_103.pdf

References for Gephyrin - 147 103

CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 147 103 WB; tested species: mouse
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Boshans LL, Soh H, Wood WM, Nolan TM, Mandoiu II, Yanagawa Y, Tzingounis AV, Nishiyama A
Scientific reports (2021) 111: 3552. 147 103 ICC; tested species: mouse
Cat. No.: 147 103
Amount: 50 µg
Price: $375.00
CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 147 103 WB; tested species: mouse
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Boshans LL, Soh H, Wood WM, Nolan TM, Mandoiu II, Yanagawa Y, Tzingounis AV, Nishiyama A
Scientific reports (2021) 111: 3552. 147 103 ICC; tested species: mouse
WB
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.
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