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Mint 1 antibody - 144 103

Mint1 is a multi-domain adaptor-protein that interacts with different neuronal proteins
Rabbit polyclonal purified antibody
Cat. No.: 144 103
Amount: 50 µg
Price: $370.00
Cat. No. 144 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 200 up to 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 2 to 265 from rat Mint1 (UniProt Id: O35430)
Reactivity Reacts with: rat (O35430), mouse (B2RUJ5).
Other species not tested yet.
Specificity Specific for Mint 1.
Matching control protein/peptide 144-1P
Data sheet 144_103.pdf

References for Mint 1 - 144 103

BACE1 controls synaptic function through modulating release of synaptic vesicles.
Das B, Singh N, Yao AY, Zhou J, He W, Hu X, Yan R
Molecular psychiatry (2021) 2611: 6394-6410. 144 103 WB; tested species: mouse
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Grønborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron (2013) 782: 285-97. 144 103 WB
A role for Sec8 in oligodendrocyte morphological differentiation.
Anitei M, Ifrim M, Ewart MA, Cowan AE, Carson JH, Bansal R, Pfeiffer SE
Journal of cell science (2006) 119Pt 5: 807-18. 144 103 WB; tested species: rat
Cat. No.: 144 103
Amount: 50 µg
Price: $370.00
BACE1 controls synaptic function through modulating release of synaptic vesicles.
Das B, Singh N, Yao AY, Zhou J, He W, Hu X, Yan R
Molecular psychiatry (2021) 2611: 6394-6410. 144 103 WB; tested species: mouse
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Grønborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron (2013) 782: 285-97. 144 103 WB
A role for Sec8 in oligodendrocyte morphological differentiation.
Anitei M, Ifrim M, Ewart MA, Cowan AE, Carson JH, Bansal R, Pfeiffer SE
Journal of cell science (2006) 119Pt 5: 807-18. 144 103 WB; tested species: rat
Background

Mints (also referred to as X11-like proteins) are adaptor-proteins that consist of divergent N-terminal sequences and conserved C-terminal PTB and PDZ domains.
Three isoforms (Mint 1, 2 and 3) have been described. Mint 1 exclusively binds to the synaptic protein CASK via its N-terminal sequence. Munc18-1 has been shown to be an interaction partner of Mint 1 and 2. The more C-terminal located PTB and PDZ domains present in all Mint isoforms bind to widely distributed proteins like APP, presenilins and Ca2+ channels.
A Mint 1 knock out had no obvious effect on brain achitecture and development, nor was synaptic plasticity in excitatory synapses affected. In inhibitory synapses of knock out strains the release of gamma-aminobutyric acid (GABA) was impaired.