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Bassoon antibody - 141 004

Bassoon is a large multi-domain protein of the presynaptic active zone
Polyclonal Guinea pig antiserum
Cat. No.: 141 004
Amount: 100 µl
Price: $375.00
Cat. No. 141 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 1000 up to 1 : 5000 gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 3569 to 3769 from rat Bassoon (UniProt Id: O88778)
Reactivity Reacts with: rat (O88778), mouse (O88737).
No signal: chicken.
Other species not tested yet.
Specificity Specific for bassoon.
Remarks

WB: Due to its large size, bassoon requires special gel-electrophoresis and Western blot protocols for visualization by immunoblotting. Excellent results can be obtained with the 4-12% TRIS-glycine gradient gels from anamed or NuPAGE 3-8% TRIS-Acetate gradient gels from invitrogen.

Data sheet 141_004.pdf

References for Bassoon - 141 004

Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 141 004 WB, ICC; tested species: rat
Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.
Feng B, Freitas AE, Gorodetski L, Wang J, Tian R, Lee YR, Grewal AS, Zou Y
Science advances (2021) 734: . 141 004 ICC, IHC; tested species: mouse
Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals.
Kang M, Lee D, Song JM, Park S, Park DH, Lee S, Suh YH
Experimental & molecular medicine (2021) : . 141 004 ICC; tested species: rat
Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.
Vardar G, Gerth F, Schmitt XJ, Rautenstrauch P, Trimbuch T, Schubert J, Lerche H, Rosenmund C, Freund C
Brain : a journal of neurology (2020) : . 141 004 ICC; tested species: mouse
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 141 004 ICC, IHC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 141 004 ICC; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 141 004 ICC; tested species: mouse
N-linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1.
Park DH, Park S, Song JM, Kang M, Lee S, Horak M, Suh YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2020) : . 141 004 ICC; tested species: rat
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 141 004 ICC; tested species: rat
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 141 004 ICC; tested species: mouse
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : . 141 004 ICC; tested species: rat
Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.
Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C, et al.
Structure (London, England : 1993) (2019) : . 141 004 ICC; tested species: mouse
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 141 004 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2018) 973: 727. 141 004 ICC; tested species: mouse
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 141 004 ICC; tested species: mouse
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 141 004 ICC; tested species: mouse
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 141 004 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 141 004 ICC; tested species: mouse
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP
Neuron (2017) 954: 779-790.e6. 141 004 ICC; tested species: human
Alternative Splicing of P/Q-Type Ca2+ Channels Shapes Presynaptic Plasticity.
Thalhammer A, Contestabile A, Ermolyuk YS, Ng T, Volynski KE, Soong TW, Goda Y, Cingolani LA
Cell reports (2017) 202: 333-343. 141 004 ICC; tested species: rat
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 141 004 ICC
Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.
Sidenstein SC, D'Este E, Böhm MJ, Danzl JG, Belov VN, Hell SW
Scientific reports (2016) 6: 26725. 141 004 ICC
Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.
Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, Niesmann K, Missler M, Heine M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3540: 13629-47. 141 004 ICC
Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
Gimber N, Tadeus G, Maritzen T, Schmoranzer J, Haucke V
Nature communications (2015) 6: 8392. 141 004 ICC; tested species: mouse
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, et al.
Cell death and differentiation (2015) 229: 1425-36. 141 004 ICC
STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.
D'Este E, Kamin D, Göttfert F, El-Hady A, Hell SW
Cell reports (2015) 108: 1246-51. 141 004 ICC; tested species: rat
A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing.
Tonna N, Bianco F, Matteoli M, Cagnoli C, Antonucci F, Manfredi A, Mauro N, Ranucci E, Ferruti P
Science and technology of advanced materials (2014) 154: 045007. 141 004 ICC
N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons.
Yam PT, Pincus Z, Gupta GD, Bashkurov M, Charron F, Pelletier L, Colman DR
PloS one (2013) 811: e79679. 141 004 ICC; tested species: rat
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Hou ZH, Yu X
The Journal of biological chemistry (2013) 2884: 2501-9. 141 004 ICC; tested species: rat
The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5.
Peng YR, Hou ZH, Yu X
Neuropharmacology (2013) 65: 232-43. 141 004 ICC
Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 141 004 ICC; tested species: mouse
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 141 004 ICC
Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.
Bartolomé-Martín D, Ramírez-Franco J, Castro E, Sánchez-Prieto J, Torres M
Journal of cell science (2012) 125Pt 2: 422-34. 141 004 ICC; tested species: rat
β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Sun Y, Bamji SX
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3147: 17123-33. 141 004 ICC
Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
Peng YR, Zeng SY, Song HL, Li MY, Yamada MK, Yu X
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3048: 16220-31. 141 004 ICC
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 141 004 WB, ICC; tested species: rat
Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.
Feng B, Freitas AE, Gorodetski L, Wang J, Tian R, Lee YR, Grewal AS, Zou Y
Science advances (2021) 734: . 141 004 ICC, IHC; tested species: mouse
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 141 004 ICC, IHC; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 141 004 IHC; tested species: mouse
Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology.
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hübner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H
Scientific reports (2019) 91: 16110. 141 004 IHC; tested species: mouse
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, et al.
eLife (2018) 7: . 141 004 IHC; tested species: mouse
StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Jacobs CL, Badiee RK, Lin MZ
Nature methods (2018) 157: 523-526. 141 004 IHC; tested species: mouse
A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity.
Schroeder A, Vanderlinden J, Vints K, Ribeiro LF, Vennekens KM, Gounko NV, Wierda KD, de Wit J
Neuron (2018) 992: 329-344.e7. 141 004 IHC; tested species: rat
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.
Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J
Neuron (2018) 1001: 201-215.e9. 141 004 IHC; tested species: mouse
Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.
Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, et al.
Neuron (2018) 975: 1137-1152.e5. 141 004 IHC; tested species: mouse
Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation.
Thakar S, Wang L, Yu T, Ye M, Onishi K, Scott J, Qi J, Fernandes C, Han X, Yates JR, Berg DK, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 1144: E610-E618. 141 004 IHC
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 141 004 IHC; tested species: mouse
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T
The EMBO journal (2014) 335: 512-27. 141 004 IHC
Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons.
Fan KY, Baufreton J, Surmeier DJ, Chan CS, Bevan MD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3240: 13718-28. 141 004 IHC
Cat. No.: 141 004
Quantity: 100 µl
Price: $375.00
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 141 004 WB, ICC; tested species: rat
Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.
Feng B, Freitas AE, Gorodetski L, Wang J, Tian R, Lee YR, Grewal AS, Zou Y
Science advances (2021) 734: . 141 004 ICC, IHC; tested species: mouse
Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals.
Kang M, Lee D, Song JM, Park S, Park DH, Lee S, Suh YH
Experimental & molecular medicine (2021) : . 141 004 ICC; tested species: rat
Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.
Vardar G, Gerth F, Schmitt XJ, Rautenstrauch P, Trimbuch T, Schubert J, Lerche H, Rosenmund C, Freund C
Brain : a journal of neurology (2020) : . 141 004 ICC; tested species: mouse
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 141 004 ICC, IHC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 141 004 ICC; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 141 004 ICC; tested species: mouse
N-linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1.
Park DH, Park S, Song JM, Kang M, Lee S, Horak M, Suh YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2020) : . 141 004 ICC; tested species: rat
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 141 004 ICC; tested species: rat
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 141 004 ICC; tested species: mouse
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : . 141 004 ICC; tested species: rat
Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.
Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C, et al.
Structure (London, England : 1993) (2019) : . 141 004 ICC; tested species: mouse
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 141 004 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2018) 973: 727. 141 004 ICC; tested species: mouse
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 141 004 ICC; tested species: mouse
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.
Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, et al.
Acta neuropathologica (2018) 1354: 529-550. 141 004 ICC; tested species: mouse
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 141 004 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 141 004 ICC; tested species: mouse
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP
Neuron (2017) 954: 779-790.e6. 141 004 ICC; tested species: human
Alternative Splicing of P/Q-Type Ca2+ Channels Shapes Presynaptic Plasticity.
Thalhammer A, Contestabile A, Ermolyuk YS, Ng T, Volynski KE, Soong TW, Goda Y, Cingolani LA
Cell reports (2017) 202: 333-343. 141 004 ICC; tested species: rat
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 141 004 ICC
Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.
Sidenstein SC, D'Este E, Böhm MJ, Danzl JG, Belov VN, Hell SW
Scientific reports (2016) 6: 26725. 141 004 ICC
Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.
Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, Niesmann K, Missler M, Heine M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3540: 13629-47. 141 004 ICC
Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
Gimber N, Tadeus G, Maritzen T, Schmoranzer J, Haucke V
Nature communications (2015) 6: 8392. 141 004 ICC; tested species: mouse
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, et al.
Cell death and differentiation (2015) 229: 1425-36. 141 004 ICC
STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.
D'Este E, Kamin D, Göttfert F, El-Hady A, Hell SW
Cell reports (2015) 108: 1246-51. 141 004 ICC; tested species: rat
A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing.
Tonna N, Bianco F, Matteoli M, Cagnoli C, Antonucci F, Manfredi A, Mauro N, Ranucci E, Ferruti P
Science and technology of advanced materials (2014) 154: 045007. 141 004 ICC
N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons.
Yam PT, Pincus Z, Gupta GD, Bashkurov M, Charron F, Pelletier L, Colman DR
PloS one (2013) 811: e79679. 141 004 ICC; tested species: rat
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Hou ZH, Yu X
The Journal of biological chemistry (2013) 2884: 2501-9. 141 004 ICC; tested species: rat
The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5.
Peng YR, Hou ZH, Yu X
Neuropharmacology (2013) 65: 232-43. 141 004 ICC
Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 141 004 ICC; tested species: mouse
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, et al.
PloS one (2012) 710: e48034. 141 004 ICC
Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.
Bartolomé-Martín D, Ramírez-Franco J, Castro E, Sánchez-Prieto J, Torres M
Journal of cell science (2012) 125Pt 2: 422-34. 141 004 ICC; tested species: rat
β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Sun Y, Bamji SX
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3147: 17123-33. 141 004 ICC
Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
Peng YR, Zeng SY, Song HL, Li MY, Yamada MK, Yu X
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3048: 16220-31. 141 004 ICC
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 141 004 WB, ICC; tested species: rat
Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.
Feng B, Freitas AE, Gorodetski L, Wang J, Tian R, Lee YR, Grewal AS, Zou Y
Science advances (2021) 734: . 141 004 ICC, IHC; tested species: mouse
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, et al.
Cell reports (2020) 3010: 3520-3535.e7. 141 004 ICC, IHC; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 141 004 IHC; tested species: mouse
Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology.
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hübner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H
Scientific reports (2019) 91: 16110. 141 004 IHC; tested species: mouse
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, et al.
eLife (2018) 7: . 141 004 IHC; tested species: mouse
StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Jacobs CL, Badiee RK, Lin MZ
Nature methods (2018) 157: 523-526. 141 004 IHC; tested species: mouse
A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity.
Schroeder A, Vanderlinden J, Vints K, Ribeiro LF, Vennekens KM, Gounko NV, Wierda KD, de Wit J
Neuron (2018) 992: 329-344.e7. 141 004 IHC; tested species: rat
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.
Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J
Neuron (2018) 1001: 201-215.e9. 141 004 IHC; tested species: mouse
Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.
Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, et al.
Neuron (2018) 975: 1137-1152.e5. 141 004 IHC; tested species: mouse
Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation.
Thakar S, Wang L, Yu T, Ye M, Onishi K, Scott J, Qi J, Fernandes C, Han X, Yates JR, Berg DK, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 1144: E610-E618. 141 004 IHC
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 141 004 IHC; tested species: mouse
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T
The EMBO journal (2014) 335: 512-27. 141 004 IHC
Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons.
Fan KY, Baufreton J, Surmeier DJ, Chan CS, Bevan MD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3240: 13718-28. 141 004 IHC
Background

Bassoon is a large protein which consists of an N-terminal Zn2+ finger and several piccolo-bassoon homology domains (PBH-domains). It is generally found together with piccolo, a related huge multi-domain protein of the CAZ (cytoskeletal matrix assembled at active zones).
Bassoon was suggested to be a scaffolding element of the presynapse but deletion experiments in mice have shown that bassoon is also involved in synaptic vesicle cycling. Probably bassoon interacts with other protein factors via its Zn2+ domain but the potential partners have not been determined yet.