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Synaptotagmin 1 antibody cytoplasmic tail - 105 011

Synaptotagmin1 is a Ca2+-sensor on synaptic vesicles that triggers neurotransmitter release
Mouse monoclonal purified IgG
Cat. No.: 105 011
Amount: 100 µg
Price: $425.00
Cat. No. 105 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
EM: yes
ELISA: yes (see remarks)
Clone 41.1
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 80 to 421 from rat Synaptotagmin1 (UniProt Id: P21707)
Epitop Epitop: AA 150 to 240 from rat Synaptotagmin1 (UniProt Id: P21707)
Reactivity Reacts with: human (P21579), rat (P21707), mouse (P46096), mammals, zebrafish.
Other species not tested yet.
Specificity Specific for mammalian synaptotagmin 1, no cross-reactivity to other synaptotagmins. K.O. PubMed: 29274147
Remarks

Since synaptotagmin 1 is unevenly expressed in neuronal subpopulations and may, in fact, be missing from some, it is less well suited as a general marker for synapses.
WBNon-boiled samples are recommended when running SDS-PAGE.
ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 105 002 as detector antibody. The ELISA-protocol for membrane proteins is recommended.

Data sheet 105_011.pdf

References for Synaptotagmin 1 - 105 011

Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release.
Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET
Cell reports (2022) 383: 110255. 105 011 WB; KD verified; tested species: rat
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 105 011 WB; tested species: mouse
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
Journal of neurochemistry (2021) 1582: 182-196. 105 011 WB; tested species: mouse
Impact of unilateral ureteral obstruction on cognition and neurodegeneration.
Ho YS, Lau CF, Lee K, Tan JY, Lee J, Yung S, Chang RC
Brain research bulletin (2021) 169: 112-127. 105 011 WB; tested species: mouse
Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.
Patzke C, Dai J, Brockmann MM, Sun Z, Fenske P, Rosenmund C, Südhof TC
Molecular psychiatry (2021) : . 105 011 WB; tested species: human
Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961. 105 011 WB; tested species: rat
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.
Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B
Toxins (2021) 138: . 105 011 WB; tested species: human
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM
Cellular and molecular life sciences : CMLS (2021) 7814: 5647-5663. 105 011 WB; tested species: mouse
Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis.
Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang H, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, et al.
JCI insight (2021) : . 105 011 WB, IHC; tested species: mouse
An optogenetic method for investigating presynaptic molecular regulation.
Kay Y, Herring BE
Scientific reports (2021) 111: 11329. 105 011 WB; KD verified; tested species: human
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986. 105 011 WB, ICC; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 105 011 WB; tested species: mouse
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 105 011 WB; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 105 011 WB, ICC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 105 011 WB; tested species: rat
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 105 011 WB; tested species: mouse
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.
Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL
Cell reports (2019) 297: 2016-2027.e4. 105 011 WB; tested species: mouse
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK, et al.
Nature communications (2019) 101: 3904. 105 011 WB; tested species: rat
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: . 105 011 WB; tested species: mouse
Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins.
Balietti M, Fattorini G, Pugliese A, Marcotulli D, Bragina L, Conti F
Frontiers in aging neuroscience (2018) 10: 91. 105 011 WB; tested species: rat
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 105 011 WB; tested species: rat
Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.
Nazir FH, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, Satir TM, Öhrfelt A, Blennow K, Agholme L, Zetterberg H, et al.
Neurochemistry international (2018) : . 105 011 WB, ICC; tested species: human
The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis.
Peggion C, Stella R, Chemello F, Massimino ML, Arrigoni G, Cagnin S, Biancotto G, Franchin C, Sorgato MC, Bertoli A
Molecular neurobiology (2018) : . 105 011 WB; tested species: mouse
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.
Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS
Proceedings of the National Academy of Sciences of the United States of America (2018) 11532: E7624-E7631. 105 011 WB; KO verified; tested species: rat
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer EM, Mim C, Jahn R, Milosevic I
eLife (2018) 7: . 105 011 WB; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 105 011 WB
JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.
Caswell PT, Dickens M
Molecular and cellular biochemistry (2017) : . 105 011 WB, ICC; tested species: rat
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 105 011 WB, ICC
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Houy S, Groffen AJ, Ziomkiewicz I, Verhage M, Pinheiro PS, Sørensen JB
eLife (2017) 6: . 105 011 WB; KO verified; tested species: mouse
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
Cao M, Wu Y, Ashrafi G, McCartney AJ, Wheeler H, Bushong EA, Boassa D, Ellisman MH, Ryan TA, De Camilli P
Neuron (2017) 934: 882-896.e5. 105 011 WB; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 105 011 WB
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 105 011 WB
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 105 011 WB, ICC
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 105 011 WB, IHC; tested species: mouse
Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.
Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T, et al.
Neuron (2015) 882: 330-44. 105 011 WB; tested species: mouse
Analysis of conditional heterozygous STXBP1 mutations in human neurons.
Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC
The Journal of clinical investigation (2015) 1259: 3560-71. 105 011 WB
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31. 105 011 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 105 011 WB
Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 105 011 WB; tested species: mouse
Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC
The EMBO journal (2013) 321: 159-71. 105 011 WB; tested species: mouse
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
Xu W, Tse YC, Dobie FA, Baudry M, Craig AM, Wong TP, Wang YT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3313: 5867-5877. 105 011 WB
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3323: 9769-80. 105 011 WB
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 105 011 WB; tested species: rat
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M, Burré J, Südhof TC
Nature cell biology (2011) 131: 30-9. 105 011 WB; tested species: mouse
Neurotoxic phospholipases directly affect synaptic vesicle function.
Treppmann P, Brunk I, Afube T, Richter K, Ahnert-Hilger G
Journal of neurochemistry (2011) 1174: 757-64. 105 011 WB; tested species: rat
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 105 011 WB, ICC; tested species: mouse
Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.
Pang ZP, Cao P, Xu W, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3011: 4132-42. 105 011 WB; tested species: mouse
Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel-Borowski K
Neuroscience (2009) 1622: 282-91. 105 011 WB; tested species: rat
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 105 011 WB; tested species: mouse
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N
Cell (2007) 1314: 796-808. 105 011 WB
Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2.
Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28123: 15671-9. 105 011 WB; tested species: mouse
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 105 011 WB; tested species: rat
Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.
Evans GJ, Morgan A
The European journal of neuroscience (2005) 2110: 2671-80. 105 011 WB, ICC
A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes.
Hu K, Rickman C, Carroll J, Davletov B
The Biochemical journal (2004) 377Pt 3: 781-5. 105 011 WB
SNAP-23 functions in docking/fusion of granules at low Ca2+.
Chieregatti E, Chicka MC, Chapman ER, Baldini G
Molecular biology of the cell (2004) 154: 1918-30. 105 011 WB, IP
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Vesicular localization and activity-dependent trafficking of presynaptic choline transporters.
Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2330: 9697-709. 105 011 WB; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 105 011 WB, IHC
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.
Chapman ER, Jahn R
The Journal of biological chemistry (1994) 2698: 5735-41. 105 011 WB
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.
Walch-Solimena C, Takei K, Marek KL, Midyett K, Südhof TC, De Camilli P, Jahn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (1993) 139: 3895-903. 105 011 WB, IP
Amyloid pathology and synaptic loss in pathological aging.
Gkanatsiou E, Nilsson J, Toomey CE, Vrillon A, Kvartsberg H, Portelius E, Zetterberg H, Blennow K, Brinkmalm A, Lashley T, Brinkmalm G, et al.
Journal of neurochemistry (2021) : . 105 011 IP; tested species: human
CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.
Xu C, Sellgren CM, Fatouros-Bergman H, Piehl F, Blennow K, Zetterberg H, Brinkmalm A, Santillo AF, Lundgren S, Cervenka S, Engberg G, et al.
IBRO reports (2020) 8: 136-142. 105 011 IP; tested species: human
CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia.
Clarke MTM, Brinkmalm A, Foiani MS, Woollacott IOC, Heller C, Heslegrave A, Keshavan A, Fox NC, Schott JM, Warren JD, Blennow K, et al.
Alzheimer's research & therapy (2019) 111: 105. 105 011 IP; tested species: human
Cerebrospinal fluid markers of extracellular matrix remodelling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy.
Fernström E, Minta K, Andreasson U, Sandelius Å, Wasling P, Brinkmalm A, Höglund K, Blennow K, Nyman J, Zetterberg H, Kalm M, et al.
Journal of internal medicine (2018) : . 105 011 IP; tested species: human
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 105 011 IP
SNAP-23 functions in docking/fusion of granules at low Ca2+.
Chieregatti E, Chicka MC, Chapman ER, Baldini G
Molecular biology of the cell (2004) 154: 1918-30. 105 011 WB, IP
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.
Walch-Solimena C, Takei K, Marek KL, Midyett K, Südhof TC, De Camilli P, Jahn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (1993) 139: 3895-903. 105 011 WB, IP
Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.
Tawfik B, Martins JS, Houy S, Imig C, Pinheiro PS, Wojcik SM, Brose N, Cooper BH, Sørensen JB
eLife (2021) 10: . 105 011 ICC; tested species: mouse
TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.
Jiang ZJ, Li W, Yao LH, Saed B, Rao Y, Grewe BS, McGinley A, Varga K, Alford S, Hu YS, Gong LW, et al.
eLife (2021) 10: . 105 011 ICC; tested species: mouse
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 105 011 ICC; tested species: rat
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986. 105 011 WB, ICC; tested species: mouse
Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, et al.
eLife (2020) 9: . 105 011 ICC; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 105 011 WB, ICC; tested species: mouse
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 105 011 ICC; tested species: mouse
Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.
Nazir FH, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, Satir TM, Öhrfelt A, Blennow K, Agholme L, Zetterberg H, et al.
Neurochemistry international (2018) : . 105 011 WB, ICC; tested species: human
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 105 011 WB, ICC
ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network.
Tomatis VM, Josh P, Papadopulos A, Gormal RS, Lanoue V, Martin S, Meunier FA
Molecular and cellular neurosciences (2017) 84: 100-111. 105 011 ICC; tested species: rat
JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.
Caswell PT, Dickens M
Molecular and cellular biochemistry (2017) : . 105 011 WB, ICC; tested species: rat
Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons.
Liu T, Li H, Hong W, Han W
Journal of neurochemistry (2016) 1395: 748-756. 105 011 ICC
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 105 011 WB, ICC
Regulation of density of functional presynaptic terminals by local energy supply.
Zhou H, Liu G
Molecular brain (2015) 8: 42. 105 011 ICC; tested species: rat
Synaptotagmin-1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons.
Greif KF, Asabere N, Lutz GJ, Gallo G
Developmental neurobiology (2013) 731: 27-44. 105 011 ICC; tested species: chicken
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
Malarkey EB, Parpura V
The Journal of physiology (2011) 58917: 4271-300. 105 011 ICC; tested species: rat
AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.
Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Boening D, Böning D, Klingauf J, Schu P, et al.
The EMBO journal (2010) 298: 1318-30. 105 011 ICC; tested species: mouse
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 105 011 WB, ICC; tested species: mouse
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis.
Willig KI, Rizzoli SO, Westphal V, Jahn R, Hell SW
Nature (2006) 4407086: 935-9. 105 011 ICC
Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.
Evans GJ, Morgan A
The European journal of neuroscience (2005) 2110: 2671-80. 105 011 WB, ICC
Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons.
Bonanomi D, Menegon A, Miccio A, Ferrari G, Corradi A, Kao HT, Benfenati F, Valtorta F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2532: 7299-308. 105 011 ICC
Calcium is Reduced in Presynaptic Mitochondria of Motor Nerve Terminals during Neurotransmission in SMA Mice.
Lopez-Manzaneda M, Franco-Espin J, Tejero R, Cano R, Tabares L
Human molecular genetics (2021) : . 105 011 IHC; tested species: mouse
Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis.
Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang H, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, et al.
JCI insight (2021) : . 105 011 WB, IHC; tested species: mouse
Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters.
Turecek J, Regehr WG
eLife (2020) 9: . 105 011 IHC; tested species: mouse
Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release.
Turecek J, Regehr WG
Neuron (2019) : . 105 011 IHC; tested species: mouse
Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.
Bouhours B, Gjoni E, Kochubey O, Schneggenburger R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3717: 4604-4617. 105 011 IHC; tested species: mouse
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 105 011 WB, IHC; tested species: mouse
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.
Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A, et al.
Nature communications (2014) 5: 4294. 105 011 IHC; tested species: mouse
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.
Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW
Proceedings of the National Academy of Sciences of the United States of America (2013) 11046: E4385-92. 105 011 IHC; tested species: mouse
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3113: 4886-95. 105 011 IHC; tested species: mouse
Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.
Xiao L, Han Y, Runne H, Murray H, Kochubey O, Luthi-Carter R, Schneggenburger R
Molecular and cellular neurosciences (2010) 444: 374-85. 105 011 IHC; tested species: rat
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3040: 13281-90. 105 011 IHC; tested species: rat
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 105 011 WB, IHC
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications (2021) 32: fcab079. 105 011 IHC-P; tested species: human
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 105 011 ELISA
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 105 011
Cat. No.: 105 011
Quantity: 100 µg
Price: $425.00
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release.
Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET
Cell reports (2022) 383: 110255. 105 011 WB; KD verified; tested species: rat
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 105 011 WB; tested species: mouse
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
Journal of neurochemistry (2021) 1582: 182-196. 105 011 WB; tested species: mouse
Impact of unilateral ureteral obstruction on cognition and neurodegeneration.
Ho YS, Lau CF, Lee K, Tan JY, Lee J, Yung S, Chang RC
Brain research bulletin (2021) 169: 112-127. 105 011 WB; tested species: mouse
Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.
Patzke C, Dai J, Brockmann MM, Sun Z, Fenske P, Rosenmund C, Südhof TC
Molecular psychiatry (2021) : . 105 011 WB; tested species: human
Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961. 105 011 WB; tested species: rat
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.
Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B
Toxins (2021) 138: . 105 011 WB; tested species: human
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM
Cellular and molecular life sciences : CMLS (2021) 7814: 5647-5663. 105 011 WB; tested species: mouse
Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis.
Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang H, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, et al.
JCI insight (2021) : . 105 011 WB, IHC; tested species: mouse
An optogenetic method for investigating presynaptic molecular regulation.
Kay Y, Herring BE
Scientific reports (2021) 111: 11329. 105 011 WB; KD verified; tested species: human
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986. 105 011 WB, ICC; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 105 011 WB; tested species: mouse
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 105 011 WB; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 105 011 WB, ICC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 105 011 WB; tested species: rat
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 105 011 WB; tested species: mouse
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.
Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL
Cell reports (2019) 297: 2016-2027.e4. 105 011 WB; tested species: mouse
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK, et al.
Nature communications (2019) 101: 3904. 105 011 WB; tested species: rat
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: . 105 011 WB; tested species: mouse
Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins.
Balietti M, Fattorini G, Pugliese A, Marcotulli D, Bragina L, Conti F
Frontiers in aging neuroscience (2018) 10: 91. 105 011 WB; tested species: rat
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 105 011 WB; tested species: rat
Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.
Nazir FH, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, Satir TM, Öhrfelt A, Blennow K, Agholme L, Zetterberg H, et al.
Neurochemistry international (2018) : . 105 011 WB, ICC; tested species: human
The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis.
Peggion C, Stella R, Chemello F, Massimino ML, Arrigoni G, Cagnin S, Biancotto G, Franchin C, Sorgato MC, Bertoli A
Molecular neurobiology (2018) : . 105 011 WB; tested species: mouse
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.
Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS
Proceedings of the National Academy of Sciences of the United States of America (2018) 11532: E7624-E7631. 105 011 WB; KO verified; tested species: rat
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer EM, Mim C, Jahn R, Milosevic I
eLife (2018) 7: . 105 011 WB; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 105 011 WB
JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.
Caswell PT, Dickens M
Molecular and cellular biochemistry (2017) : . 105 011 WB, ICC; tested species: rat
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 105 011 WB, ICC
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Houy S, Groffen AJ, Ziomkiewicz I, Verhage M, Pinheiro PS, Sørensen JB
eLife (2017) 6: . 105 011 WB; KO verified; tested species: mouse
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
Cao M, Wu Y, Ashrafi G, McCartney AJ, Wheeler H, Bushong EA, Boassa D, Ellisman MH, Ryan TA, De Camilli P
Neuron (2017) 934: 882-896.e5. 105 011 WB; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 105 011 WB
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 105 011 WB
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 105 011 WB, ICC
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 105 011 WB, IHC; tested species: mouse
Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.
Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T, et al.
Neuron (2015) 882: 330-44. 105 011 WB; tested species: mouse
Analysis of conditional heterozygous STXBP1 mutations in human neurons.
Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC
The Journal of clinical investigation (2015) 1259: 3560-71. 105 011 WB
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31. 105 011 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 105 011 WB
Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 105 011 WB; tested species: mouse
Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC
The EMBO journal (2013) 321: 159-71. 105 011 WB; tested species: mouse
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
Xu W, Tse YC, Dobie FA, Baudry M, Craig AM, Wong TP, Wang YT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3313: 5867-5877. 105 011 WB
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3323: 9769-80. 105 011 WB
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 105 011 WB; tested species: rat
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M, Burré J, Südhof TC
Nature cell biology (2011) 131: 30-9. 105 011 WB; tested species: mouse
Neurotoxic phospholipases directly affect synaptic vesicle function.
Treppmann P, Brunk I, Afube T, Richter K, Ahnert-Hilger G
Journal of neurochemistry (2011) 1174: 757-64. 105 011 WB; tested species: rat
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 105 011 WB, ICC; tested species: mouse
Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.
Pang ZP, Cao P, Xu W, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3011: 4132-42. 105 011 WB; tested species: mouse
Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel-Borowski K
Neuroscience (2009) 1622: 282-91. 105 011 WB; tested species: rat
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 105 011 WB; tested species: mouse
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N
Cell (2007) 1314: 796-808. 105 011 WB
Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2.
Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28123: 15671-9. 105 011 WB; tested species: mouse
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 105 011 WB; tested species: rat
Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.
Evans GJ, Morgan A
The European journal of neuroscience (2005) 2110: 2671-80. 105 011 WB, ICC
A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes.
Hu K, Rickman C, Carroll J, Davletov B
The Biochemical journal (2004) 377Pt 3: 781-5. 105 011 WB
SNAP-23 functions in docking/fusion of granules at low Ca2+.
Chieregatti E, Chicka MC, Chapman ER, Baldini G
Molecular biology of the cell (2004) 154: 1918-30. 105 011 WB, IP
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Vesicular localization and activity-dependent trafficking of presynaptic choline transporters.
Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2330: 9697-709. 105 011 WB; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 105 011 WB, IHC
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.
Chapman ER, Jahn R
The Journal of biological chemistry (1994) 2698: 5735-41. 105 011 WB
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.
Walch-Solimena C, Takei K, Marek KL, Midyett K, Südhof TC, De Camilli P, Jahn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (1993) 139: 3895-903. 105 011 WB, IP
Amyloid pathology and synaptic loss in pathological aging.
Gkanatsiou E, Nilsson J, Toomey CE, Vrillon A, Kvartsberg H, Portelius E, Zetterberg H, Blennow K, Brinkmalm A, Lashley T, Brinkmalm G, et al.
Journal of neurochemistry (2021) : . 105 011 IP; tested species: human
CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.
Xu C, Sellgren CM, Fatouros-Bergman H, Piehl F, Blennow K, Zetterberg H, Brinkmalm A, Santillo AF, Lundgren S, Cervenka S, Engberg G, et al.
IBRO reports (2020) 8: 136-142. 105 011 IP; tested species: human
CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia.
Clarke MTM, Brinkmalm A, Foiani MS, Woollacott IOC, Heller C, Heslegrave A, Keshavan A, Fox NC, Schott JM, Warren JD, Blennow K, et al.
Alzheimer's research & therapy (2019) 111: 105. 105 011 IP; tested species: human
Cerebrospinal fluid markers of extracellular matrix remodelling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy.
Fernström E, Minta K, Andreasson U, Sandelius Å, Wasling P, Brinkmalm A, Höglund K, Blennow K, Nyman J, Zetterberg H, Kalm M, et al.
Journal of internal medicine (2018) : . 105 011 IP; tested species: human
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 105 011 IP
SNAP-23 functions in docking/fusion of granules at low Ca2+.
Chieregatti E, Chicka MC, Chapman ER, Baldini G
Molecular biology of the cell (2004) 154: 1918-30. 105 011 WB, IP
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.
Walch-Solimena C, Takei K, Marek KL, Midyett K, Südhof TC, De Camilli P, Jahn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (1993) 139: 3895-903. 105 011 WB, IP
Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.
Tawfik B, Martins JS, Houy S, Imig C, Pinheiro PS, Wojcik SM, Brose N, Cooper BH, Sørensen JB
eLife (2021) 10: . 105 011 ICC; tested species: mouse
TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.
Jiang ZJ, Li W, Yao LH, Saed B, Rao Y, Grewe BS, McGinley A, Varga K, Alford S, Hu YS, Gong LW, et al.
eLife (2021) 10: . 105 011 ICC; tested species: mouse
Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi Z, Walde M, Klementowicz AE, Paraskevopoulou F, Woehler A
iScience (2021) 241: 101909. 105 011 ICC; tested species: rat
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986. 105 011 WB, ICC; tested species: mouse
Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, et al.
eLife (2020) 9: . 105 011 ICC; tested species: mouse
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.
Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266. 105 011 WB, ICC; tested species: mouse
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 105 011 ICC; tested species: mouse
Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.
Nazir FH, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, Satir TM, Öhrfelt A, Blennow K, Agholme L, Zetterberg H, et al.
Neurochemistry international (2018) : . 105 011 WB, ICC; tested species: human
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 105 011 WB, ICC
ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network.
Tomatis VM, Josh P, Papadopulos A, Gormal RS, Lanoue V, Martin S, Meunier FA
Molecular and cellular neurosciences (2017) 84: 100-111. 105 011 ICC; tested species: rat
JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.
Caswell PT, Dickens M
Molecular and cellular biochemistry (2017) : . 105 011 WB, ICC; tested species: rat
Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons.
Liu T, Li H, Hong W, Han W
Journal of neurochemistry (2016) 1395: 748-756. 105 011 ICC
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 105 011 WB, ICC
Regulation of density of functional presynaptic terminals by local energy supply.
Zhou H, Liu G
Molecular brain (2015) 8: 42. 105 011 ICC; tested species: rat
Synaptotagmin-1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons.
Greif KF, Asabere N, Lutz GJ, Gallo G
Developmental neurobiology (2013) 731: 27-44. 105 011 ICC; tested species: chicken
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
Malarkey EB, Parpura V
The Journal of physiology (2011) 58917: 4271-300. 105 011 ICC; tested species: rat
AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.
Glyvuk N, Tsytsyura Y, Geumann C, D'Hooge R, Hüve J, Kratzke M, Baltes J, Boening D, Böning D, Klingauf J, Schu P, et al.
The EMBO journal (2010) 298: 1318-30. 105 011 ICC; tested species: mouse
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: . 105 011 WB, ICC; tested species: mouse
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis.
Willig KI, Rizzoli SO, Westphal V, Jahn R, Hell SW
Nature (2006) 4407086: 935-9. 105 011 ICC
Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.
Evans GJ, Morgan A
The European journal of neuroscience (2005) 2110: 2671-80. 105 011 WB, ICC
Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons.
Bonanomi D, Menegon A, Miccio A, Ferrari G, Corradi A, Kao HT, Benfenati F, Valtorta F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2532: 7299-308. 105 011 ICC
Calcium is Reduced in Presynaptic Mitochondria of Motor Nerve Terminals during Neurotransmission in SMA Mice.
Lopez-Manzaneda M, Franco-Espin J, Tejero R, Cano R, Tabares L
Human molecular genetics (2021) : . 105 011 IHC; tested species: mouse
Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis.
Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang H, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, et al.
JCI insight (2021) : . 105 011 WB, IHC; tested species: mouse
Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters.
Turecek J, Regehr WG
eLife (2020) 9: . 105 011 IHC; tested species: mouse
Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release.
Turecek J, Regehr WG
Neuron (2019) : . 105 011 IHC; tested species: mouse
Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.
Bouhours B, Gjoni E, Kochubey O, Schneggenburger R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3717: 4604-4617. 105 011 IHC; tested species: mouse
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16. 105 011 WB, IHC; tested species: mouse
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.
Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A, et al.
Nature communications (2014) 5: 4294. 105 011 IHC; tested species: mouse
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.
Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW
Proceedings of the National Academy of Sciences of the United States of America (2013) 11046: E4385-92. 105 011 IHC; tested species: mouse
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3113: 4886-95. 105 011 IHC; tested species: mouse
Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.
Xiao L, Han Y, Runne H, Murray H, Kochubey O, Luthi-Carter R, Schneggenburger R
Molecular and cellular neurosciences (2010) 444: 374-85. 105 011 IHC; tested species: rat
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3040: 13281-90. 105 011 IHC; tested species: rat
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 105 011 WB, IP, IHC; tested species: mouse
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 105 011 WB, IHC
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications (2021) 32: fcab079. 105 011 IHC-P; tested species: human
Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes.
Redecker P
Cell and tissue research (1996) 2833: 443-54. 105 011 WB, IHC, EM; tested species: rat
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 105 011 ELISA
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 105 011
Background
Synaptotagmin 1 also known as p65, is an integral membrane glycoprotein of neuronal synaptic vesicles and secretory granules of neuroendocrine cells that is widely (but not ubiquitously) expressed in the central and peripheral nervous system. It has a variable N-terminal domain that is exposed to the lumen of the vesicle and a conserved cytoplasmic tail that contains two Ca2+-binding C2-domains.
Ca2+-binding to synaptotagmin triggers exocytosis of synaptic vesicles, thus linking Ca2+-influx during depolarization to neurotransmitter release.
Lumenal antibodies were used in living neurons to label synaptic vesicles from the outside via endocytotic uptake.