Cat. No.: 102 011
Amount: 100 µg
Price:
415.00 €
| Cat. No. 102 011 | 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use. |
| Applications |
WB: 1 : 1000 AP staining gallery IP: not tested yet ICC: 1 : 500 gallery IHC: 1 : 1000 up to 1 : 2000 (see remarks) gallery IHC-P/FFPE: 1 : 1000 gallery |
| Clone | 44E3D12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831) |
| Epitop |
Epitop: AA 250 to 263 from rat Synaptoporin (UniProt Id: P22831) |
| Reactivity |
Reacts with: mouse (Q8BGN8), rat (P22831). Other species not tested yet. |
| Specificity | Specific for synaptoporin. |
| Matching control protein/peptide | 102-1P |
| Remarks |
IHC: In addition to the expected strong mossy fibre staining, this antibody shows some weak unspecific staining of cell bodies in the cortex, striatum and cerebellum. |
| Data sheet | 102_011.pdf |
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Synaptoporin, also known as synaptophysin 2 and p38-2, is highly homologous to synaptophysin 1 but encoded by a different gene. Like synaptopysin 1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin 1, it is not glycosylated.
The distributions of synaptophysin 1 and synaptoporin are different. Synaptophysin 1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.
