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Synaptophysin1 antibody - 101 203

Synaptophysin is a major synaptic vesicle membrane protein and a useful neuroendocrine tumor marker
Rabbit polyclonal purified antibody
Cat. No.: 101 203
Amount: 50 µg
Price: $375.00
Cat. No. 101 203 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 5000 up to 1 : 10000 AP staining gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 229 to 287 from rat Synaptophysin1 (UniProt Id: P07825)
Reactivity Reacts with: mouse (Q62277), rat (P07825).
Other species not tested yet.
Data sheet 101_203.pdf

References for Synaptophysin1 - 101 203

Excessive proteostasis contributes to pathology in fragile X syndrome.
Louros SR, Seo SS, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M, Verity NC, Wills JC, Li KW, Nolan MF, Osterweil EK, et al.
Neuron (2023) 1114: 508-525.e7. 101 203 WB; tested species: mouse
Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.
Petkova-Tuffy A, Gödecke N, Viotti J, Korte M, Dresbach T
BMC biology (2021) 191: 215. 101 203 ICC; tested species: rat
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy.
Schmitt LI, David C, Steffen R, Hezel S, Roos A, Schara-Schmidt U, Kleinschnitz C, Leo M, Hagenacker T
Acta neuropathologica (2023) : . 101 203 IHC; tested species: mouse
Cat. No.: 101 203
Amount: 50 µg
Price: $375.00
Excessive proteostasis contributes to pathology in fragile X syndrome.
Louros SR, Seo SS, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M, Verity NC, Wills JC, Li KW, Nolan MF, Osterweil EK, et al.
Neuron (2023) 1114: 508-525.e7. 101 203 WB; tested species: mouse
Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.
Petkova-Tuffy A, Gödecke N, Viotti J, Korte M, Dresbach T
BMC biology (2021) 191: 215. 101 203 ICC; tested species: rat
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy.
Schmitt LI, David C, Steffen R, Hezel S, Roos A, Schara-Schmidt U, Kleinschnitz C, Leo M, Hagenacker T
Acta neuropathologica (2023) : . 101 203 IHC; tested species: mouse
Background

Synaptophysin 1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin 1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin 1 and synaptobrevin 2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin 1 represents a small protein family with two additonal members, synaptoporin (synaptophysin 2) and panthophysin. Like synaptophysin 1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin 1 on synaptic vesicles whereas panthophysin is expressed in all tissues.