Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.Öttl M, Toonen RF, Verhage M
Human molecular genetics (2024) : .
101 004 ICC; tested species: stem cells
Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.Seibert MJ, Evans CS, Stanley KS, Wu Z, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 439: 1475-1491.
101 004 ICC; tested species: mouse
Functional inhibition of katanin affects synaptic plasticity.Lombino FL, Schwarz JR, Pechmann Y, Schweizer M, Jark R, Stange O, Glatzel M, Gee CE, Hausrat TJ, Gromova KV, Kneussel M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) : .
101 004 ICC; tested species: mouse
High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral AM, Demiautte F, Lambert E, Vandeputte A, Brodin P, Mendes T, Lambert JC, et al.
Current protocols (2023) 310: e904.
101 004 ICC; tested species: rat
Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: .
101 004 ICC; tested species: mouse
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.Hennlein L, Ghanawi H, Gerstner F, Palominos García E, Yildirim E, Saal-Bauernschubert L, Moradi M, Deng C, Klein T, Appenzeller S, Sauer M, et al.
The Journal of cell biology (2023) 2223: .
101 004 ICC, IHC; tested species: mouse
Power and optimal study design in iPSC-based brain disease modelling.Brunner JW, Lammertse HCA, van Berkel AA, Koopmans F, Li KW, Smit AB, Toonen RF, Verhage M, van der Sluis S
Molecular psychiatry (2022) : .
101 004 ICC; tested species: human
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, et al.
Nature neuroscience (2022) : .
101 004 ICC; tested species: human
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus-response in spinal muscular atrophy.Deng C, Reinhard S, Hennlein L, Eilts J, Sachs S, Doose S, Jablonka S, Sauer M, Moradi M, Sendtner M
Translational neurodegeneration (2022) 111: 31.
101 004 ICC; tested species: mouse
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, et al.
Cell reports (2022) : 111896.
101 004 ICC; tested species: human
Intraneuronal tau aggregation induces the integrated stress response in astrocytes.Batenburg KL, Kasri NN, Heine VM, Scheper W
Journal of molecular cell biology (2022) : .
101 004 ICC; tested species: human
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS
eLife (2022) 11: .
101 004 ICC; tested species: mouse
Rebuilding essential active zone functions within a synapse.Tan C, Wang SSH, de Nola G, Kaeser PS
Neuron (2022) 1109: 1498-1515.e8.
101 004 ICC; tested species: mouse
The Coding and Small Non-coding Hippocampal Synaptic RNAome.Epple R, Krüger D, Berulava T, Brehm G, Islam R, Köster S, Fischer A
Molecular neurobiology (2021) : .
101 004 ICC; tested species: mouse
Presynaptic activity and protein turnover are correlated at the single-synapse level.Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841.
101 004 ICC; tested species: rat
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: .
101 004 WB, ICC; tested species: mouse
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
Nature communications (2021) 121: 3057.
101 004 ICC; tested species: mouse
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons.Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO
Scientific reports (2021) 111: 17374.
101 004 ICC; tested species: rat
A microRNA signature that correlates with cognition and is a target against cognitive decline.Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, et al.
EMBO molecular medicine (2021) : e13659.
101 004 ICC; tested species: mouse
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, et al.
Cancer cell (2021) 398: 1115-1134.e12.
101 004 ICC, IHC; tested species: mouse
Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization.Bhattacharya U, Jhou JF, Zou YF, Abrigo G, Lin SW, Chen YH, Chien FC, Tai HC
Scientific reports (2021) 111: 18583.
101 004 ICC; tested species: mouse
MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.Habekost M, Jørgensen AL, Qvist P, Denham M
Stem cell research (2020) 48: 101984.
101 004 ICC; tested species: pig
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, et al.
Nature communications (2020) 111: 2729.
101 004 ICC; tested species: rat
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7.
101 004 ICC; tested species: mouse
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9.
101 004 ICC; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: .
101 004 ICC; tested species: mouse
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, et al.
Cell reports (2020) 337: 108398.
101 004 ICC; tested species: mouse
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission.André T, Classen J, Brenner P, Betts M, Dörr B, Kreye S, Zuidinga B, Meijer M, Russell RB, Verhage M, Söllner TH, et al.
eNeuro (2020) : .
101 004 ICC; tested species: mouse
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M
Stem cell research (2020) 48: 101945.
101 004 ICC; tested species: human
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO
The EMBO journal (2020) : e104596.
101 004 ICC; tested species: rat
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712.
101 004 ICC; tested species: mouse
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER
Neuron (2020) : .
101 004 ICC; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: .
101 004 ICC; tested species: rat
A practical guide to optimization in X10 expansion microscopy.Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : .
101 004 ICC; tested species: rat
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253.
101 004 ICC, IHC; tested species: mouse,rat
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM
Developmental cell (2019) : .
101 004 ICC; tested species: human
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH
Acta neuropathologica communications (2019) 71: 6.
101 004 ICC; tested species: mouse
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289.
101 004 ICC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11.
101 004 WB, ICC; tested species: mouse
Critical role for piccolo in synaptic vesicle retrieval.Ackermann F, Schink KO, Bruns C, Izsvák Z, Hamra FK, Rosenmund C, Garner CC
eLife (2019) 8: .
101 004 ICC; tested species: rat
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.Courtney NA, Bao H, Briguglio JS, Chapman ER
Nature communications (2019) 101: 4076.
101 004 ICC; tested species: mouse
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports (2019) 91: 8179.
101 004 ICC; tested species: mouse
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports (2019) : e48143.
101 004 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421.
101 004 ICC; tested species: mouse
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M
Journal of neurochemistry (2018) 1443: 241-254.
101 004 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14.
101 004 ICC; tested species: mouse
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : .
101 004 ICC; tested species: rat
The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : .
101 004 ICC; tested species: mouse
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160.
101 004 ICC; tested species: mouse
BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal-Bauernschubert L, Jablonka S
Frontiers in molecular neuroscience (2017) 10: 346.
101 004 ICC; tested species: mouse
SNAP-25 gene family members differentially support secretory vesicle fusion.Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889.
101 004 ICC; tested species: mouse
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells.Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V
PloS one (2017) 1210: e0186636.
101 004 ICC; tested species: human
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981.
101 004 ICC; tested species: rat
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678.
101 004 IHC, ICC, WB
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170.
101 004 ICC, WB
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57.
101 004 ICC; KO verified
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496.
101 004 ICC; tested species: rat
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.Xue R, Gaffaney JD, Chapman ER
Proceedings of the National Academy of Sciences of the United States of America (2015) 11231: E4316-25.
101 004 ICC; tested species: mouse
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78.
101 004 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77.
101 004 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8.
101 004 ICC; tested species: rat
Correlated optical and isotopic nanoscopy.Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT
Nature communications (2014) 5: 3664.
101 004 ICC; tested species: rat
Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A
PloS one (2013) 83: e58814.
101 004 ICC; tested species: mouse
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT
The Journal of biological chemistry (2011) 28630: 26828-37.
101 004 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200.
101 004 ICC
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.Maidorn M, Olichon A, Rizzoli SO, Opazo F
mAbs () 112: 305-321.
101 004 ICC; tested species: mouse