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Synaptophysin1 antibody - 101 004

Synaptophysin is a major synaptic vesicle membrane protein and a useful neuroendocrine tumor marker
Guinea pig polyclonal antiserum
Cat. No.: 101 004
Amount: 100 µl
Price: $400.00
Cat. No. 101 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 200 gallery  
iDISCO: 1 : 100
Clarity: 1 : 500 (see remarks)
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human Synaptophysin (UniProt Id: P08247)
Reactivity Reacts with: human (P08247), rat (P07825), mouse (Q62277), hamster, cow, chicken, frog.
Other species not tested yet.
Matching control protein/peptide 101-0P
Remarks

Clarity: This antibody has been successfully used for CLARITY application in human brain (Woelfle et al. 2022. bioRxiv)

Data sheet 101_004.pdf

References for Synaptophysin1 - 101 004

N-glycoproteomics of brain synapses and synaptic vesicles.
Bradberry MM, Peters-Clarke TM, Shishkova E, Chapman ER, Coon JJ
Cell reports (2023) 424: 112368. 101 004 WB; tested species: mouse
The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling.
Gromova KV, Thies E, Janiesch PC, Lützenkirchen FP, Zhu Y, Stajano D, Dürst CD, Schweizer M, Konietzny A, Mikhaylova M, Gee CE, et al.
Cell reports (2023) 427: 112743. 101 004 WB; tested species: mouse
A novel role for MLC1 in regulating astrocyte-synapse interactions.
Kater MSJ, Baumgart KF, Badia-Soteras A, Heistek TS, Carney KE, Timmerman AJ, van Weering JRT, Smit AB, van der Knaap MS, Mansvelder HD, Verheijen MHG, et al.
Glia (2023) 717: 1770-1785. 101 004 WB; tested species: mouse
Rapid and gentle immunopurification of brain synaptic vesicles.
Bradberry MM, Mishra S, Zhang Z, Wu L, McKetney JM, Vestling MM, Coon JJ, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 101 004 WB; tested species: mouse
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 101 004 WB; tested species: mouse
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
Peter S, Urbanus BHA, Klaassen RV, Wu B, Boele HJ, Azizi S, Slotman JA, Houtsmuller AB, Schonewille M, Hoebeek FE, Spijker S, et al.
Cell reports (2020) 312: 107515. 101 004 WB; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 101 004 WB; tested species: rat
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, et al.
Cell reports (2019) 287: 1799-1813.e5. 101 004 WB; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 101 004 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 ICC, WB
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.
Öttl M, Toonen RF, Verhage M
Human molecular genetics (2024) : . 101 004 ICC; tested species: stem cells
Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
Seibert MJ, Evans CS, Stanley KS, Wu Z, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 439: 1475-1491. 101 004 ICC; tested species: mouse
Functional inhibition of katanin affects synaptic plasticity.
Lombino FL, Schwarz JR, Pechmann Y, Schweizer M, Jark R, Stange O, Glatzel M, Gee CE, Hausrat TJ, Gromova KV, Kneussel M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) : . 101 004 ICC; tested species: mouse
High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.
Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral AM, Demiautte F, Lambert E, Vandeputte A, Brodin P, Mendes T, Lambert JC, et al.
Current protocols (2023) 310: e904. 101 004 ICC; tested species: rat
Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: . 101 004 ICC; tested species: mouse
The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes.
Krohn J, Domart F, Do TT, Dresbach T
Glia (2023) : . 101 004 ICC; tested species: mouse
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
Hennlein L, Ghanawi H, Gerstner F, Palominos García E, Yildirim E, Saal-Bauernschubert L, Moradi M, Deng C, Klein T, Appenzeller S, Sauer M, et al.
The Journal of cell biology (2023) 2223: . 101 004 ICC, IHC; tested species: mouse
Power and optimal study design in iPSC-based brain disease modelling.
Brunner JW, Lammertse HCA, van Berkel AA, Koopmans F, Li KW, Smit AB, Toonen RF, Verhage M, van der Sluis S
Molecular psychiatry (2022) : . 101 004 ICC; tested species: human
α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 101 004 ICC; tested species: mouse
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, et al.
Nature neuroscience (2022) : . 101 004 ICC; tested species: human
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus-response in spinal muscular atrophy.
Deng C, Reinhard S, Hennlein L, Eilts J, Sachs S, Doose S, Jablonka S, Sauer M, Moradi M, Sendtner M
Translational neurodegeneration (2022) 111: 31. 101 004 ICC; tested species: mouse
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.
Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, et al.
Cell reports (2022) : 111896. 101 004 ICC; tested species: human
Intraneuronal tau aggregation induces the integrated stress response in astrocytes.
Batenburg KL, Kasri NN, Heine VM, Scheper W
Journal of molecular cell biology (2022) : . 101 004 ICC; tested species: human
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.
Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS
eLife (2022) 11: . 101 004 ICC; tested species: mouse
Rebuilding essential active zone functions within a synapse.
Tan C, Wang SSH, de Nola G, Kaeser PS
Neuron (2022) 1109: 1498-1515.e8. 101 004 ICC; tested species: mouse
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Neuron-Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures.
Dooves S, van Velthoven AJH, Suciati LG, Heine VM
Cells (2021) 101: . 101 004 ICC; tested species: human
The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Epple R, Krüger D, Berulava T, Brehm G, Islam R, Köster S, Fischer A
Molecular neurobiology (2021) : . 101 004 ICC; tested species: mouse
Presynaptic activity and protein turnover are correlated at the single-synapse level.
Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841. 101 004 ICC; tested species: rat
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.
Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
Nature communications (2021) 121: 3057. 101 004 ICC; tested species: mouse
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons.
Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO
Scientific reports (2021) 111: 17374. 101 004 ICC; tested species: rat
The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.
Mori Y, Takenaka KI, Fukazawa Y, Takamori S
Communications biology (2021) 41: 981. 101 004 ICC; tested species: mouse
A microRNA signature that correlates with cognition and is a target against cognitive decline.
Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, et al.
EMBO molecular medicine (2021) : e13659. 101 004 ICC; tested species: mouse
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, et al.
Cancer cell (2021) 398: 1115-1134.e12. 101 004 ICC, IHC; tested species: mouse
Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization.
Bhattacharya U, Jhou JF, Zou YF, Abrigo G, Lin SW, Chen YH, Chien FC, Tai HC
Scientific reports (2021) 111: 18583. 101 004 ICC; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.
Habekost M, Jørgensen AL, Qvist P, Denham M
Stem cell research (2020) 48: 101984. 101 004 ICC; tested species: pig
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, et al.
Nature communications (2020) 111: 2729. 101 004 ICC; tested species: rat
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 101 004 ICC; tested species: mouse
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 101 004 ICC; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 004 ICC; tested species: mouse
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, et al.
Cell reports (2020) 337: 108398. 101 004 ICC; tested species: mouse
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission.
André T, Classen J, Brenner P, Betts M, Dörr B, Kreye S, Zuidinga B, Meijer M, Russell RB, Verhage M, Söllner TH, et al.
eNeuro (2020) : . 101 004 ICC; tested species: mouse
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.
Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M
Stem cell research (2020) 48: 101945. 101 004 ICC; tested species: human
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO
The EMBO journal (2020) : e104596. 101 004 ICC; tested species: rat
Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons.
Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M
Scientific reports (2020) 101: 10913. 101 004 ICC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 004 ICC; tested species: mouse
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER
Neuron (2020) : . 101 004 ICC; tested species: mouse
A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity.
Classen J, Saarloos I, Meijer M, Sullivan PF, Verhage M
Scientific reports (2020) 101: 3181. 101 004 ICC; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 101 004 ICC; tested species: rat
A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 101 004 ICC; tested species: rat
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM
Developmental cell (2019) : . 101 004 ICC; tested species: human
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH
Acta neuropathologica communications (2019) 71: 6. 101 004 ICC; tested species: mouse
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 101 004 ICC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann F, Schink KO, Bruns C, Izsvák Z, Hamra FK, Rosenmund C, Garner CC
eLife (2019) 8: . 101 004 ICC; tested species: rat
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
Courtney NA, Bao H, Briguglio JS, Chapman ER
Nature communications (2019) 101: 4076. 101 004 ICC; tested species: mouse
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports (2019) 91: 8179. 101 004 ICC; tested species: mouse
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports (2019) : e48143. 101 004 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 101 004 ICC; tested species: mouse
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M
Journal of neurochemistry (2018) 1443: 241-254. 101 004 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 101 004 ICC; tested species: mouse
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 101 004 ICC; tested species: rat
The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.
Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 ICC; tested species: mouse
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 101 004 ICC; tested species: mouse
BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).
Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal-Bauernschubert L, Jablonka S
Frontiers in molecular neuroscience (2017) 10: 346. 101 004 ICC; tested species: mouse
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 101 004 ICC; tested species: mouse
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells.
Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V
PloS one (2017) 1210: e0186636. 101 004 ICC; tested species: human
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 101 004 ICC; tested species: rat
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 ICC, WB
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57. 101 004 ICC; KO verified
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 101 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 101 004 ICC; tested species: rat
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Xue R, Gaffaney JD, Chapman ER
Proceedings of the National Academy of Sciences of the United States of America (2015) 11231: E4316-25. 101 004 ICC; tested species: mouse
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 101 004 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 101 004 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 101 004 ICC; tested species: rat
Correlated optical and isotopic nanoscopy.
Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT
Nature communications (2014) 5: 3664. 101 004 ICC; tested species: rat
Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A
PloS one (2013) 83: e58814. 101 004 ICC; tested species: mouse
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT
The Journal of biological chemistry (2011) 28630: 26828-37. 101 004 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 004 ICC
Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression.
Jacobs S, Nathwani M, Doering LC
BMC neuroscience (2010) 11: 132. 101 004 ICC
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
Maidorn M, Olichon A, Rizzoli SO, Opazo F
mAbs () 112: 305-321. 101 004 ICC; tested species: mouse
Interrelationships Between Spinal Sympathetic Preganglionic Neurons, Autonomic Systems and Electrical Synapses Formed by Connexin36-containing Gap Junctions.
Recabal-Beyer A, Tavakoli H, Senecal JMM, Stecina K, Nagy JI
Neuroscience (2023) 523: 31-46. 101 004 IHC; tested species: mouse
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.
He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, Hu X, Liu C, Shao Y, Wang S, Chen L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 4313: 2305-2325. 101 004 IHC; tested species: mouse
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
Hennlein L, Ghanawi H, Gerstner F, Palominos García E, Yildirim E, Saal-Bauernschubert L, Moradi M, Deng C, Klein T, Appenzeller S, Sauer M, et al.
The Journal of cell biology (2023) 2223: . 101 004 ICC, IHC; tested species: mouse
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice.
Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, et al.
Nature communications (2022) 131: 4418. 101 004 IHC; tested species: mouse
Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury.
Lavoie NS, Truong V, Malone D, Pengo T, Patil N, Dutton JR, Parr AM
Journal of cellular and molecular medicine (2022) : . 101 004 IHC; tested species: rat
Disrupted presynaptic nectin1-based neuronal adhesion in the entorhinal-hippocampal circuit contributes to early-life stress-induced memory deficits.
Wu C, Gong Q, Xu X, Fang P, Wang C, Yu JY, Wang XX, Fang SH, Chen WJ, Lou HF, Liu YH, et al.
Translational psychiatry (2022) 121: 141. 101 004 IHC; tested species: mouse
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment.
Rauskolb S, Andreska T, Fries S, von Collenberg CR, Blum R, Monoranu CM, Villmann C, Sendtner M
Acta neuropathologica communications (2022) 101: 68. 101 004 IHC; tested species: mouse
Control of mammalian locomotion by ventral spinocerebellar tract neurons.
Chalif JI, Martínez-Silva ML, Pagiazitis JG, Murray AJ, Mentis GZ
Cell (2022) 1852: 328-344.e26. 101 004 IHC; tested species: mouse
Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis.
Salvany S, Casanovas A, Piedrafita L, Gras S, Calderó J, Esquerda JE
Brain pathology (Zurich, Switzerland) (2022) : . 101 004 IHC; tested species: mouse
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
Rosen SF, Soung AL, Yang W, Ai S, Kanmogne M, Davé VA, Artyomov M, Magee JA, Klein RS
Genome medicine (2022) 141: 108. 101 004 IHC; tested species: mouse
Presymptomatic macrophage targeting has a long-lasting therapeutic effect on treatment termination in a mouse model of Charcot-Marie-Tooth 1.
Ostertag C, Klein D, Martini R
Experimental neurology (2022) 357: 114195. 101 004 IHC; tested species: mouse
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.
Evans EE, Mishra V, Mallow C, Gersz EM, Balch L, Howell A, Reilly C, Smith ES, Fisher TL, Zauderer M
Journal of neuroinflammation (2022) 191: 200. 101 004 IHC; tested species: mouse
Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA.
Carlini MJ, Triplett MK, Pellizzoni L
PloS one (2022) 178: e0267990. 101 004 IHC; tested species: mouse
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
Beckman D, Bonillas A, Diniz GB, Ott S, Roh JW, Elizaldi SR, Schmidt BA, Sammak RL, Van Rompay KKA, Iyer SS, Morrison JH, et al.
Cell reports (2022) 415: 111573. 101 004 IHC; tested species: monkey
SMN controls neuromuscular junction integrity through U7 snRNP.
Tisdale S, Van Alstyne M, Simon CM, Mentis GZ, Pellizzoni L
Cell reports (2022) 4012: 111393. 101 004 IHC; tested species: mouse
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
Eicher AK, Kechele DO, Sundaram N, Berns HM, Poling HM, Haines LE, Sanchez JG, Kishimoto K, Krishnamurthy M, Han L, Zorn AM, et al.
Cell stem cell (2022) 291: 36-51.e6. 101 004 IHC; tested species: human
IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state.
Soung AL, Davé VA, Garber C, Tycksen ED, Vollmer LL, Klein RS
Brain, behavior, and immunity (2021) : . 101 004 IHC; tested species: mouse
Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice.
Becker A, Helmuth M, Trzeczak D, Chindo BA
Journal of ethnopharmacology (2021) 278: 114219. 101 004 IHC; tested species: mouse
Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy.
Yeo SH, Herde MK, Herbison AE
Journal of neuroendocrinology (2021) 339: e13021. 101 004 IHC; tested species: mouse
Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models.
Buettner JM, Sime Longang JK, Gerstner F, Apel KS, Blanco-Redondo B, Sowoidnich L, Janzen E, Langenhan T, Wirth B, Simon CM
iScience (2021) 2411: 103376. 101 004 IHC; tested species: mouse
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Straka T, Schröder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R
Frontiers in physiology (2021) 12: 626707. 101 004 IHC, iDISCO; tested species: mouse
Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat.
Shepard CT, Pocratsky AM, Brown BL, Van Rijswijck MA, Zalla RM, Burke DA, Morehouse JR, Riegler AS, Whittemore SR, Magnuson DS
eLife (2021) 10: . 101 004 IHC; tested species: rat
Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss.
Verdoodt D, Peeleman N, Szewczyk K, Van Camp G, Ponsaerts P, Van Rompaey V
International journal of molecular sciences (2021) 2221: . 101 004 IHC; tested species: mouse
Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.
Liu X, Yeo SH, McQuillan HJ, Herde MK, Hessler S, Cheong I, Porteous R, Herbison AE
eLife (2021) 10: . 101 004 IHC; tested species: mouse
Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity.
Ciarpella F, Zamfir RG, Campanelli A, Ren E, Pedrotti G, Bottani E, Borioli A, Caron D, Di Chio M, Dolci S, Ahtiainen A, et al.
iScience (2021) 2412: 103438. 101 004 IHC; tested species: mouse
Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity.
Franken TP, Bondy BJ, Haimes DB, Goldwyn JH, Golding NL, Smith PH, Joris PX
eLife (2021) 10: . 101 004 IHC
Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem.
Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, et al.
Cell (2021) 18414: 3762-3773.e10. 101 004 IHC; tested species: mouse
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, et al.
Cancer cell (2021) 398: 1115-1134.e12. 101 004 ICC, IHC; tested species: mouse
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat.
García-Díaz C, Gil-Miravet I, Albert-Gasco H, Mañas-Ojeda A, Ros-Bernal F, Castillo-Gómez E, Gundlach AL, Olucha-Bordonau FE
Frontiers in neuroanatomy (2021) 15: 674649. 101 004 IHC; tested species: rat
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.
Amani M, Lauterborn JC, Le AA, Cox BM, Wang W, Quintanilla J, Cox CD, Gall CM, Lynch G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 004 IHC; tested species: rat
Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery.
Alvarez-Suarez P, Nowak N, Protasiuk-Filipunas A, Yamazaki H, Prószyński TJ, Gawor M
International journal of molecular sciences (2021) 2217: . 101 004 IHC; tested species: mouse
Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.
Vahdat S, Pendharkar AV, Chiang T, Harvey S, Uchino H, Cao Z, Kim A, Choy M, Chen H, Lee HJ, Cheng MY, et al.
Science advances (2021) 733: . 101 004 IHC; tested species: mouse
Aberrant axo-axonic synaptic reorganization in the phosphorylated L1-CAM/calcium channel subunit alpha2 delta-1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model.
Yamanaka H, Okubo M, Kobayashi K, Noguchi K
eNeuro (2021) : . 101 004 IHC; tested species: rat
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury.
Salvany S, Casanovas A, Piedrafita L, Tarabal O, Hernández S, Calderó J, Esquerda JE
Glia (2021) : . 101 004 IHC; tested species: mouse
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE
Human molecular genetics (2020) 2916: 2647-2661. 101 004 IHC; tested species: mouse
Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice.
Wang L, Guo W, Shen X, Yeo S, Long H, Wang Z, Lyu Q, Herbison AE, Kuang Y
eLife (2020) 9: . 101 004 IHC; tested species: mouse
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I
Stem cell research & therapy (2020) 111: 238. 101 004 IHC; tested species: mouse
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T
Neuron (2020) : . 101 004 IHC; tested species: mouse
Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem.
Milinkeviciute G, Henningfield CM, Muniak MA, Chokr SM, Green KN, Cramer KS
Frontiers in neural circuits (2019) 13: 55. 101 004 IHC; tested species: mouse
Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study.
Grycz K, Głowacka A, Ji B, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M
PloS one (2019) 149: e0222849. 101 004 IHC; tested species: rat
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, et al.
Neuron (2019) : . 101 004 IHC; tested species: mouse
Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence.
Wallrafen R, Dresbach T, Viotti JS
Journal of visualized experiments : JoVE (2019) 143: . 101 004 IHC; tested species: mouse
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.
Orav E, Dowavic I, Huupponen J, Taira T, Lauri SE
Molecular neurobiology (2019) : . 101 004 IHC; tested species: mouse
Noncoding deletions reveal a gene that is critical for intestinal function.
Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, et al.
Nature (2019) : . 101 004 IHC; tested species: mouse
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 004 IHC; tested species: mouse
Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J
NPJ Regenerative medicine (2019) 4: 13. 101 004 IHC; tested species: mouse
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, et al.
Neuron (2019) : . 101 004 IHC; tested species: human,mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 101 004 IHC; tested species: mouse
Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice-New Options to Study Glaucoma Disease.
Reinehr S, Reinhard J, Wiemann S, Hesse K, Voss C, Gandej M, Dick HB, Faissner A, Joachim SC
International journal of molecular sciences (2019) 2010: . 101 004 IHC; tested species: mouse
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws.
Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD
Cell reports (2019) 298: 2192-2201.e3. 101 004 IHC; tested species: mouse
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Vukojicic A, Delestrée N, Fletcher EV, Pagiazitis JG, Sankaranarayanan S, Yednock TA, Barres BA, Mentis GZ
Cell reports (2019) 2910: 3087-3100.e7. 101 004 IHC; tested species: mouse
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.
Beckman D, Ott S, Donis-Cox K, Janssen WG, Bliss-Moreau E, Rudebeck PH, Baxter MG, Morrison JH
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 101 004 IHC; tested species: monkey
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L
Cell reports (2019) 2912: 3885-3901.e5. 101 004 IHC; tested species: mouse
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, et al.
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites.
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N
Nature neuroscience (2018) 213: 353-363. 101 004 IHC; tested species: mouse
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nature immunology (2018) 192: 151-161. 101 004 IHC; tested species: mouse
Macrophage depletion ameliorates peripheral neuropathy in aging mice.
Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, Martini R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 IHC; tested species: mouse
Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.
Ruyle BC, Klutho PJ, Baines CP, Heesch CM, Hasser EM
American journal of physiology. Regulatory, integrative and comparative physiology (2018) : . 101 004 IHC; tested species: rat
The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.
Wallrafen R, Dresbach T
Frontiers in neuroanatomy (2018) 12: 58. 101 004 IHC; tested species: mouse
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T
Proceedings of the National Academy of Sciences of the United States of America (2017) 11439: E8294-E8303. 101 004 IHC; tested species: mouse
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3721: 5345-5365. 101 004 IHC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 101 004 IHC; tested species: mouse
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
Klein D, Patzkó Á, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R
Brain : a journal of neurology (2015) 138Pt 11: 3193-205. 101 004 IHC; tested species: mouse
GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.
Schnorbusch K, Lembrechts R, Pintelon I, Timmermans JP, Brouns I, Adriaensen D
Histochemistry and cell biology (2013) 1405: 549-66. 101 004 IHC
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Austgen JR, Dantzler HA, Barger BK, Kline DD
Journal of neurophysiology (2012) 1088: 2292-305. 101 004 IHC; tested species: rat
DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses.
Asghari Adib E, Shadrach JL, Reilly-Jankowiak L, Dwivedi MK, Rogers AE, Shahzad S, Passino R, Giger RJ, Pierchala BA, Collins CA
Cell reports (2024) 432: 113801. 101 004 IHC-Fr; tested species: mouse
Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells.
Ciarpella F, Zamfir RG, Campanelli A, Pedrotti G, Di Chio M, Bottani E, Decimo I
STAR protocols (2023) 43: 102413. 101 004 IHC-Fr; tested species: mouse
Heat denaturation enables multicolor X10-STED microscopy.
Saal KA, Shaib AH, Mougios N, Crzan D, Opazo F, Rizzoli SO
Scientific reports (2023) 131: 5366. 101 004 ExM; tested species: rat
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Straka T, Schröder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R
Frontiers in physiology (2021) 12: 626707. 101 004 IHC, iDISCO; tested species: mouse
CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, Deisseroth K, Michaelis J, Boeckers TM, Schön M
BMC biology (2023) 211: 113. 101 004 Clarity; tested species: human
Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Demuth H, Hosseini S, Düsedeau HP, Dunay IR, Korte M, Zagrebelsky M
Frontiers in molecular neuroscience (2023) 16: 1163087. 101 004 FACS; tested species: mouse
Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.
Düsedau HP, Steffen J, Figueiredo CA, Boehme JD, Schultz K, Erck C, Korte M, Faber-Zuschratter H, Smalla KH, Dieterich D, Kröger A, et al.
mBio (2021) 125: e0177621. 101 004 FACS; tested species: mouse
Cat. No.: 101 004
Amount: 100 µl
Price: $400.00
N-glycoproteomics of brain synapses and synaptic vesicles.
Bradberry MM, Peters-Clarke TM, Shishkova E, Chapman ER, Coon JJ
Cell reports (2023) 424: 112368. 101 004 WB; tested species: mouse
The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling.
Gromova KV, Thies E, Janiesch PC, Lützenkirchen FP, Zhu Y, Stajano D, Dürst CD, Schweizer M, Konietzny A, Mikhaylova M, Gee CE, et al.
Cell reports (2023) 427: 112743. 101 004 WB; tested species: mouse
A novel role for MLC1 in regulating astrocyte-synapse interactions.
Kater MSJ, Baumgart KF, Badia-Soteras A, Heistek TS, Carney KE, Timmerman AJ, van Weering JRT, Smit AB, van der Knaap MS, Mansvelder HD, Verheijen MHG, et al.
Glia (2023) 717: 1770-1785. 101 004 WB; tested species: mouse
Rapid and gentle immunopurification of brain synaptic vesicles.
Bradberry MM, Mishra S, Zhang Z, Wu L, McKetney JM, Vestling MM, Coon JJ, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 101 004 WB; tested species: mouse
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.
Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, et al.
PLoS biology (2020) 181: e3000604. 101 004 WB; tested species: mouse
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
Peter S, Urbanus BHA, Klaassen RV, Wu B, Boele HJ, Azizi S, Slotman JA, Houtsmuller AB, Schonewille M, Hoebeek FE, Spijker S, et al.
Cell reports (2020) 312: 107515. 101 004 WB; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P
Journal of neurochemistry (2020) : . 101 004 WB; tested species: rat
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, et al.
Cell reports (2019) 287: 1799-1813.e5. 101 004 WB; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 101 004 WB; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 ICC, WB
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.
Öttl M, Toonen RF, Verhage M
Human molecular genetics (2024) : . 101 004 ICC; tested species: stem cells
Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
Seibert MJ, Evans CS, Stanley KS, Wu Z, Chapman ER
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 439: 1475-1491. 101 004 ICC; tested species: mouse
Functional inhibition of katanin affects synaptic plasticity.
Lombino FL, Schwarz JR, Pechmann Y, Schweizer M, Jark R, Stange O, Glatzel M, Gee CE, Hausrat TJ, Gromova KV, Kneussel M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) : . 101 004 ICC; tested species: mouse
High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.
Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral AM, Demiautte F, Lambert E, Vandeputte A, Brodin P, Mendes T, Lambert JC, et al.
Current protocols (2023) 310: e904. 101 004 ICC; tested species: rat
Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M
eLife (2023) 12: . 101 004 ICC; tested species: mouse
The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes.
Krohn J, Domart F, Do TT, Dresbach T
Glia (2023) : . 101 004 ICC; tested species: mouse
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
Hennlein L, Ghanawi H, Gerstner F, Palominos García E, Yildirim E, Saal-Bauernschubert L, Moradi M, Deng C, Klein T, Appenzeller S, Sauer M, et al.
The Journal of cell biology (2023) 2223: . 101 004 ICC, IHC; tested species: mouse
Power and optimal study design in iPSC-based brain disease modelling.
Brunner JW, Lammertse HCA, van Berkel AA, Koopmans F, Li KW, Smit AB, Toonen RF, Verhage M, van der Sluis S
Molecular psychiatry (2022) : . 101 004 ICC; tested species: human
α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 101 004 ICC; tested species: mouse
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, et al.
Nature neuroscience (2022) : . 101 004 ICC; tested species: human
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus-response in spinal muscular atrophy.
Deng C, Reinhard S, Hennlein L, Eilts J, Sachs S, Doose S, Jablonka S, Sauer M, Moradi M, Sendtner M
Translational neurodegeneration (2022) 111: 31. 101 004 ICC; tested species: mouse
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.
Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, et al.
Cell reports (2022) : 111896. 101 004 ICC; tested species: human
Intraneuronal tau aggregation induces the integrated stress response in astrocytes.
Batenburg KL, Kasri NN, Heine VM, Scheper W
Journal of molecular cell biology (2022) : . 101 004 ICC; tested species: human
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.
Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS
eLife (2022) 11: . 101 004 ICC; tested species: mouse
Rebuilding essential active zone functions within a synapse.
Tan C, Wang SSH, de Nola G, Kaeser PS
Neuron (2022) 1109: 1498-1515.e8. 101 004 ICC; tested species: mouse
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
Neuron-Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures.
Dooves S, van Velthoven AJH, Suciati LG, Heine VM
Cells (2021) 101: . 101 004 ICC; tested species: human
The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Epple R, Krüger D, Berulava T, Brehm G, Islam R, Köster S, Fischer A
Molecular neurobiology (2021) : . 101 004 ICC; tested species: mouse
Presynaptic activity and protein turnover are correlated at the single-synapse level.
Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841. 101 004 ICC; tested species: rat
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 101 004 WB, ICC; tested species: mouse
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.
Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
Nature communications (2021) 121: 3057. 101 004 ICC; tested species: mouse
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons.
Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO
Scientific reports (2021) 111: 17374. 101 004 ICC; tested species: rat
The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.
Mori Y, Takenaka KI, Fukazawa Y, Takamori S
Communications biology (2021) 41: 981. 101 004 ICC; tested species: mouse
A microRNA signature that correlates with cognition and is a target against cognitive decline.
Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, et al.
EMBO molecular medicine (2021) : e13659. 101 004 ICC; tested species: mouse
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, et al.
Cancer cell (2021) 398: 1115-1134.e12. 101 004 ICC, IHC; tested species: mouse
Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization.
Bhattacharya U, Jhou JF, Zou YF, Abrigo G, Lin SW, Chen YH, Chien FC, Tai HC
Scientific reports (2021) 111: 18583. 101 004 ICC; tested species: mouse
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
Vevea JD, Chapman ER
eLife (2020) 9: . 101 004 WB, ICC; tested species: mouse
MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons.
Habekost M, Jørgensen AL, Qvist P, Denham M
Stem cell research (2020) 48: 101984. 101 004 ICC; tested species: pig
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, et al.
Nature communications (2020) 111: 2729. 101 004 ICC; tested species: rat
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 101 004 ICC; tested species: mouse
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.
Held RG, Liu C, Ma K, Ramsey AM, Tarr TB, De Nola G, Wang SSH, Wang J, van den Maagdenberg AMJM, Schneider T, Sun J, et al.
Neuron (2020) 1074: 667-683.e9. 101 004 ICC; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 101 004 ICC; tested species: mouse
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, et al.
Cell reports (2020) 337: 108398. 101 004 ICC; tested species: mouse
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission.
André T, Classen J, Brenner P, Betts M, Dörr B, Kreye S, Zuidinga B, Meijer M, Russell RB, Verhage M, Söllner TH, et al.
eNeuro (2020) : . 101 004 ICC; tested species: mouse
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.
Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M
Stem cell research (2020) 48: 101945. 101 004 ICC; tested species: human
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO
The EMBO journal (2020) : e104596. 101 004 ICC; tested species: rat
Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons.
Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M
Scientific reports (2020) 101: 10913. 101 004 ICC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 101 004 ICC; tested species: mouse
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER
Neuron (2020) : . 101 004 ICC; tested species: mouse
A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity.
Classen J, Saarloos I, Meijer M, Sullivan PF, Verhage M
Scientific reports (2020) 101: 3181. 101 004 ICC; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 101 004 ICC; tested species: rat
A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 101 004 ICC; tested species: rat
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM
Developmental cell (2019) : . 101 004 ICC; tested species: human
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH
Acta neuropathologica communications (2019) 71: 6. 101 004 ICC; tested species: mouse
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 101 004 ICC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 101 004 WB, ICC; tested species: mouse
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann F, Schink KO, Bruns C, Izsvák Z, Hamra FK, Rosenmund C, Garner CC
eLife (2019) 8: . 101 004 ICC; tested species: rat
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
Courtney NA, Bao H, Briguglio JS, Chapman ER
Nature communications (2019) 101: 4076. 101 004 ICC; tested species: mouse
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports (2019) 91: 8179. 101 004 ICC; tested species: mouse
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports (2019) : e48143. 101 004 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 101 004 ICC; tested species: mouse
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M
Journal of neurochemistry (2018) 1443: 241-254. 101 004 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 101 004 ICC; tested species: mouse
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 101 004 ICC; tested species: rat
The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux Through Synaptic Fusion Pores.
Chiang CW, Chang CW, Jackson MB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 ICC; tested species: mouse
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 101 004 ICC; tested species: mouse
BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).
Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal-Bauernschubert L, Jablonka S
Frontiers in molecular neuroscience (2017) 10: 346. 101 004 ICC; tested species: mouse
SNAP-25 gene family members differentially support secretory vesicle fusion.
Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF
Journal of cell science (2017) 13011: 1877-1889. 101 004 ICC; tested species: mouse
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells.
Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V
PloS one (2017) 1210: e0186636. 101 004 ICC; tested species: human
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR, et al.
EMBO reports (2017) 186: 962-981. 101 004 ICC; tested species: rat
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 101 004 ICC, WB
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB
The Journal of biological chemistry (2016) 2916: 2848-57. 101 004 ICC; KO verified
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 101 004 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 101 004 ICC; tested species: rat
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Xue R, Gaffaney JD, Chapman ER
Proceedings of the National Academy of Sciences of the United States of America (2015) 11231: E4316-25. 101 004 ICC; tested species: mouse
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 101 004 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 101 004 ICC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 101 004 ICC; tested species: rat
Correlated optical and isotopic nanoscopy.
Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT
Nature communications (2014) 5: 3664. 101 004 ICC; tested species: rat
Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A
PloS one (2013) 83: e58814. 101 004 ICC; tested species: mouse
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT
The Journal of biological chemistry (2011) 28630: 26828-37. 101 004 ICC; tested species: rat
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 101 004 ICC
Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression.
Jacobs S, Nathwani M, Doering LC
BMC neuroscience (2010) 11: 132. 101 004 ICC
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
Maidorn M, Olichon A, Rizzoli SO, Opazo F
mAbs () 112: 305-321. 101 004 ICC; tested species: mouse
Interrelationships Between Spinal Sympathetic Preganglionic Neurons, Autonomic Systems and Electrical Synapses Formed by Connexin36-containing Gap Junctions.
Recabal-Beyer A, Tavakoli H, Senecal JMM, Stecina K, Nagy JI
Neuroscience (2023) 523: 31-46. 101 004 IHC; tested species: mouse
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.
He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, Hu X, Liu C, Shao Y, Wang S, Chen L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 4313: 2305-2325. 101 004 IHC; tested species: mouse
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
Hennlein L, Ghanawi H, Gerstner F, Palominos García E, Yildirim E, Saal-Bauernschubert L, Moradi M, Deng C, Klein T, Appenzeller S, Sauer M, et al.
The Journal of cell biology (2023) 2223: . 101 004 ICC, IHC; tested species: mouse
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice.
Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, et al.
Nature communications (2022) 131: 4418. 101 004 IHC; tested species: mouse
Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury.
Lavoie NS, Truong V, Malone D, Pengo T, Patil N, Dutton JR, Parr AM
Journal of cellular and molecular medicine (2022) : . 101 004 IHC; tested species: rat
Disrupted presynaptic nectin1-based neuronal adhesion in the entorhinal-hippocampal circuit contributes to early-life stress-induced memory deficits.
Wu C, Gong Q, Xu X, Fang P, Wang C, Yu JY, Wang XX, Fang SH, Chen WJ, Lou HF, Liu YH, et al.
Translational psychiatry (2022) 121: 141. 101 004 IHC; tested species: mouse
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment.
Rauskolb S, Andreska T, Fries S, von Collenberg CR, Blum R, Monoranu CM, Villmann C, Sendtner M
Acta neuropathologica communications (2022) 101: 68. 101 004 IHC; tested species: mouse
Control of mammalian locomotion by ventral spinocerebellar tract neurons.
Chalif JI, Martínez-Silva ML, Pagiazitis JG, Murray AJ, Mentis GZ
Cell (2022) 1852: 328-344.e26. 101 004 IHC; tested species: mouse
Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis.
Salvany S, Casanovas A, Piedrafita L, Gras S, Calderó J, Esquerda JE
Brain pathology (Zurich, Switzerland) (2022) : . 101 004 IHC; tested species: mouse
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
Rosen SF, Soung AL, Yang W, Ai S, Kanmogne M, Davé VA, Artyomov M, Magee JA, Klein RS
Genome medicine (2022) 141: 108. 101 004 IHC; tested species: mouse
Presymptomatic macrophage targeting has a long-lasting therapeutic effect on treatment termination in a mouse model of Charcot-Marie-Tooth 1.
Ostertag C, Klein D, Martini R
Experimental neurology (2022) 357: 114195. 101 004 IHC; tested species: mouse
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity.
Evans EE, Mishra V, Mallow C, Gersz EM, Balch L, Howell A, Reilly C, Smith ES, Fisher TL, Zauderer M
Journal of neuroinflammation (2022) 191: 200. 101 004 IHC; tested species: mouse
Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA.
Carlini MJ, Triplett MK, Pellizzoni L
PloS one (2022) 178: e0267990. 101 004 IHC; tested species: mouse
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
Beckman D, Bonillas A, Diniz GB, Ott S, Roh JW, Elizaldi SR, Schmidt BA, Sammak RL, Van Rompay KKA, Iyer SS, Morrison JH, et al.
Cell reports (2022) 415: 111573. 101 004 IHC; tested species: monkey
SMN controls neuromuscular junction integrity through U7 snRNP.
Tisdale S, Van Alstyne M, Simon CM, Mentis GZ, Pellizzoni L
Cell reports (2022) 4012: 111393. 101 004 IHC; tested species: mouse
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
Eicher AK, Kechele DO, Sundaram N, Berns HM, Poling HM, Haines LE, Sanchez JG, Kishimoto K, Krishnamurthy M, Han L, Zorn AM, et al.
Cell stem cell (2022) 291: 36-51.e6. 101 004 IHC; tested species: human
IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state.
Soung AL, Davé VA, Garber C, Tycksen ED, Vollmer LL, Klein RS
Brain, behavior, and immunity (2021) : . 101 004 IHC; tested species: mouse
Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice.
Becker A, Helmuth M, Trzeczak D, Chindo BA
Journal of ethnopharmacology (2021) 278: 114219. 101 004 IHC; tested species: mouse
Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy.
Yeo SH, Herde MK, Herbison AE
Journal of neuroendocrinology (2021) 339: e13021. 101 004 IHC; tested species: mouse
Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models.
Buettner JM, Sime Longang JK, Gerstner F, Apel KS, Blanco-Redondo B, Sowoidnich L, Janzen E, Langenhan T, Wirth B, Simon CM
iScience (2021) 2411: 103376. 101 004 IHC; tested species: mouse
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Straka T, Schröder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R
Frontiers in physiology (2021) 12: 626707. 101 004 IHC, iDISCO; tested species: mouse
Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat.
Shepard CT, Pocratsky AM, Brown BL, Van Rijswijck MA, Zalla RM, Burke DA, Morehouse JR, Riegler AS, Whittemore SR, Magnuson DS
eLife (2021) 10: . 101 004 IHC; tested species: rat
Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss.
Verdoodt D, Peeleman N, Szewczyk K, Van Camp G, Ponsaerts P, Van Rompaey V
International journal of molecular sciences (2021) 2221: . 101 004 IHC; tested species: mouse
Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.
Liu X, Yeo SH, McQuillan HJ, Herde MK, Hessler S, Cheong I, Porteous R, Herbison AE
eLife (2021) 10: . 101 004 IHC; tested species: mouse
Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity.
Ciarpella F, Zamfir RG, Campanelli A, Ren E, Pedrotti G, Bottani E, Borioli A, Caron D, Di Chio M, Dolci S, Ahtiainen A, et al.
iScience (2021) 2412: 103438. 101 004 IHC; tested species: mouse
Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity.
Franken TP, Bondy BJ, Haimes DB, Goldwyn JH, Golding NL, Smith PH, Joris PX
eLife (2021) 10: . 101 004 IHC
Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem.
Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, et al.
Cell (2021) 18414: 3762-3773.e10. 101 004 IHC; tested species: mouse
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, et al.
Cancer cell (2021) 398: 1115-1134.e12. 101 004 ICC, IHC; tested species: mouse
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat.
García-Díaz C, Gil-Miravet I, Albert-Gasco H, Mañas-Ojeda A, Ros-Bernal F, Castillo-Gómez E, Gundlach AL, Olucha-Bordonau FE
Frontiers in neuroanatomy (2021) 15: 674649. 101 004 IHC; tested species: rat
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.
Amani M, Lauterborn JC, Le AA, Cox BM, Wang W, Quintanilla J, Cox CD, Gall CM, Lynch G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 101 004 IHC; tested species: rat
Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery.
Alvarez-Suarez P, Nowak N, Protasiuk-Filipunas A, Yamazaki H, Prószyński TJ, Gawor M
International journal of molecular sciences (2021) 2217: . 101 004 IHC; tested species: mouse
Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.
Vahdat S, Pendharkar AV, Chiang T, Harvey S, Uchino H, Cao Z, Kim A, Choy M, Chen H, Lee HJ, Cheng MY, et al.
Science advances (2021) 733: . 101 004 IHC; tested species: mouse
Aberrant axo-axonic synaptic reorganization in the phosphorylated L1-CAM/calcium channel subunit alpha2 delta-1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model.
Yamanaka H, Okubo M, Kobayashi K, Noguchi K
eNeuro (2021) : . 101 004 IHC; tested species: rat
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury.
Salvany S, Casanovas A, Piedrafita L, Tarabal O, Hernández S, Calderó J, Esquerda JE
Glia (2021) : . 101 004 IHC; tested species: mouse
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE
Human molecular genetics (2020) 2916: 2647-2661. 101 004 IHC; tested species: mouse
Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice.
Wang L, Guo W, Shen X, Yeo S, Long H, Wang Z, Lyu Q, Herbison AE, Kuang Y
eLife (2020) 9: . 101 004 IHC; tested species: mouse
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I
Stem cell research & therapy (2020) 111: 238. 101 004 IHC; tested species: mouse
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T
Neuron (2020) : . 101 004 IHC; tested species: mouse
Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem.
Milinkeviciute G, Henningfield CM, Muniak MA, Chokr SM, Green KN, Cramer KS
Frontiers in neural circuits (2019) 13: 55. 101 004 IHC; tested species: mouse
Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study.
Grycz K, Głowacka A, Ji B, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M
PloS one (2019) 149: e0222849. 101 004 IHC; tested species: rat
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, et al.
Neuron (2019) : . 101 004 IHC; tested species: mouse
Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence.
Wallrafen R, Dresbach T, Viotti JS
Journal of visualized experiments : JoVE (2019) 143: . 101 004 IHC; tested species: mouse
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ
PLoS biology (2019) 175: e3000253. 101 004 ICC, IHC; tested species: mouse,rat
NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.
Orav E, Dowavic I, Huupponen J, Taira T, Lauri SE
Molecular neurobiology (2019) : . 101 004 IHC; tested species: mouse
Noncoding deletions reveal a gene that is critical for intestinal function.
Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, et al.
Nature (2019) : . 101 004 IHC; tested species: mouse
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 101 004 IHC; tested species: mouse
Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J
NPJ Regenerative medicine (2019) 4: 13. 101 004 IHC; tested species: mouse
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.
Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, et al.
Neuron (2019) : . 101 004 IHC; tested species: human,mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 101 004 IHC; tested species: mouse
Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice-New Options to Study Glaucoma Disease.
Reinehr S, Reinhard J, Wiemann S, Hesse K, Voss C, Gandej M, Dick HB, Faissner A, Joachim SC
International journal of molecular sciences (2019) 2010: . 101 004 IHC; tested species: mouse
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws.
Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD
Cell reports (2019) 298: 2192-2201.e3. 101 004 IHC; tested species: mouse
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Vukojicic A, Delestrée N, Fletcher EV, Pagiazitis JG, Sankaranarayanan S, Yednock TA, Barres BA, Mentis GZ
Cell reports (2019) 2910: 3087-3100.e7. 101 004 IHC; tested species: mouse
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.
Beckman D, Ott S, Donis-Cox K, Janssen WG, Bliss-Moreau E, Rudebeck PH, Baxter MG, Morrison JH
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 101 004 IHC; tested species: monkey
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L
Cell reports (2019) 2912: 3885-3901.e5. 101 004 IHC; tested species: mouse
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, et al.
Nature neuroscience (2019) : . 101 004 IHC; tested species: mouse
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites.
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N
Nature neuroscience (2018) 213: 353-363. 101 004 IHC; tested species: mouse
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nature immunology (2018) 192: 151-161. 101 004 IHC; tested species: mouse
Macrophage depletion ameliorates peripheral neuropathy in aging mice.
Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, Martini R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 101 004 IHC; tested species: mouse
Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.
Ruyle BC, Klutho PJ, Baines CP, Heesch CM, Hasser EM
American journal of physiology. Regulatory, integrative and comparative physiology (2018) : . 101 004 IHC; tested species: rat
The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.
Wallrafen R, Dresbach T
Frontiers in neuroanatomy (2018) 12: 58. 101 004 IHC; tested species: mouse
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T
Proceedings of the National Academy of Sciences of the United States of America (2017) 11439: E8294-E8303. 101 004 IHC; tested species: mouse
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3721: 5345-5365. 101 004 IHC; tested species: mouse
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678. 101 004 IHC, ICC, WB
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 101 004 IHC; tested species: mouse
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
Klein D, Patzkó Á, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R
Brain : a journal of neurology (2015) 138Pt 11: 3193-205. 101 004 IHC; tested species: mouse
GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.
Schnorbusch K, Lembrechts R, Pintelon I, Timmermans JP, Brouns I, Adriaensen D
Histochemistry and cell biology (2013) 1405: 549-66. 101 004 IHC
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Austgen JR, Dantzler HA, Barger BK, Kline DD
Journal of neurophysiology (2012) 1088: 2292-305. 101 004 IHC; tested species: rat
DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses.
Asghari Adib E, Shadrach JL, Reilly-Jankowiak L, Dwivedi MK, Rogers AE, Shahzad S, Passino R, Giger RJ, Pierchala BA, Collins CA
Cell reports (2024) 432: 113801. 101 004 IHC-Fr; tested species: mouse
Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells.
Ciarpella F, Zamfir RG, Campanelli A, Pedrotti G, Di Chio M, Bottani E, Decimo I
STAR protocols (2023) 43: 102413. 101 004 IHC-Fr; tested species: mouse
Heat denaturation enables multicolor X10-STED microscopy.
Saal KA, Shaib AH, Mougios N, Crzan D, Opazo F, Rizzoli SO
Scientific reports (2023) 131: 5366. 101 004 ExM; tested species: rat
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Straka T, Schröder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R
Frontiers in physiology (2021) 12: 626707. 101 004 IHC, iDISCO; tested species: mouse
CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, Deisseroth K, Michaelis J, Boeckers TM, Schön M
BMC biology (2023) 211: 113. 101 004 Clarity; tested species: human
Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Demuth H, Hosseini S, Düsedeau HP, Dunay IR, Korte M, Zagrebelsky M
Frontiers in molecular neuroscience (2023) 16: 1163087. 101 004 FACS; tested species: mouse
Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.
Düsedau HP, Steffen J, Figueiredo CA, Boehme JD, Schultz K, Erck C, Korte M, Faber-Zuschratter H, Smalla KH, Dieterich D, Kröger A, et al.
mBio (2021) 125: e0177621. 101 004 FACS; tested species: mouse
Background

Synaptophysin 1, also referred to as p38-1, is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It is currently the most widely used marker for nerve terminals and probably the best marker for the pathologist in differentiating neuroendocrine tumors.
Synaptophysin 1 has four transmembrane domains with both N- and C-terminus facing the cytoplasm. It binds to synaptobrevin 1 and synaptobrevin 2 in detergent extracts but its function has not been elucidated completely. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis. As typical for synaptic vesicle proteins, synaptophysin 1 represents a small protein family with two additonal members, synaptoporin (synaptophysin 2) and panthophysin. Like synaptophysin 1, synaptoporin is widely expressed in neurons and colocalizes with synaptophysin 1 on synaptic vesicles whereas panthophysin is expressed in all tissues.