Cat. No.: 184 003
Amount: 50 µg
Price:
$455.00
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| Cat. No. 184 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 1 to 232 from rat Velis1 (UniProt Id: Q9Z250) |
| Reactivity |
Reacts with: human (O14910, Q9HAP6, Q9NUP9), rat (Q9Z250, Q9Z252, Q792I0), mouse (Q8JZS0, O88951, O88952), zebrafish. Other species not tested yet. |
| Specificity | Recognizes all three isoforms veli 1, 2 and 3. |
| Matching control protein/peptide | 184-0P |
| Remarks |
IHC: This antibody requires mild fixation. |
| Data sheet | 184_003.pdf |
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The complex of the multi-adaptor-proteins CASK, Mint and Veli, also referred to as MALS and Lin 7, is conserved across kingdoms and may be involved in localizing synaptic vesicles at synaptic terminals. Three Veli isoforms (1, 2 and 3) with different expression patterns have been described, so far.
Veli proteins have also been suggested to participate in regulating the recruitment of neurotransmitter receptors to the post synaptic density (PSD) by interaction with their PDZ domains.